DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(z)12 and suz12

DIOPT Version :9

Sequence 1:	NP_730465.1	Gene:	Su(z)12 / 48071	FlyBaseID:	FBgn0020887	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_012822185.1	Gene:	suz12 / 779745	XenbaseID:	XB-GENE-997462	Length:	729	Species:	Xenopus tropicalis

Alignment Length:	816	Identity:	290/816 - (35%)
Similarity:	423/816 - (51%)	Gaps:	179/816 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPAKKREKDSNPDGSAANGIIGLTHGAPDASNAGSTVPPTAEGQVKLNGHQQEQELFLQAFEKP 65
            |||.|.       .||:|      ..|.|.|  |.|.:|..   :.|:...|.:.||||||||||
Frog     1 MAPQKH-------GGSSA------PSGKPSA--AASLLPVR---KPKMEQIQADHELFLQAFEKP 47

  Fly    66 TQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESI-----TQKSEAVSQNYL 125
            |||||:||.|:...||||:|||:||..|.||:|.||.:|:||.:|..:     .|:|.:||. :|
Frog    48 TQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRSNAKRKTFKVNDLLLKVEKMKGDQESHSVSA-HL 111

  Fly   126 HVIYDSLHEKLPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRK-------------- 176
            .:.:.....|:.....|...|.           .||::|..|.|:...|||
Frog   112 QLTFTGFFHKIDKPSQNSENEQ-----------SSVTLEVLLVKVCHKKRKARYNDSVAVQASPR 165

  Fly   177 ----DSTLDFQELLSKCS-----------QIVYNPKDRVGEHAT---ISIPLQTMRPMGEQHTL- 222
                |..|:.|..|...|           |:..||:....:.:|   :::......| ...|.:
Frog   166 SAGNDPKLEGQHFLGDVSCPIRQVPTGKKQVPLNPELNPAKPSTFPSLAVSSNEFEP-SNSHMVK 229

  Fly   223 -YKLLFRIKVLSPSTCN-------DEN---AETPPNKRSR------PNEKMFGSELILYEKSSGF 270
             |.||||:........|       :||   :|.||.:|.|      ..:|.|.:::.:::|:...
Frog   230 SYSLLFRVTRQGRRDFNGLTNGETNENIDVSEEPPARRKRNSSNRDEGDKTFVAQMTVFDKNRRL 294

  Fly   271 -ITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPD-SYIPLSLTYDVYQQSPMLKFHLTLSNEQLP 333
             :.:||||..:|.:....:   :.|:.||||:.| ..:|   .::.:.|.|.|:|.|..:|: .|
Frog   295 QLLDGEYEVAMQEMEDCPV---NKKRATWETILDGKRLP---PFETFSQGPTLQFTLRWTND-TP 352

  Fly   334 EMISAPELQRYVQHLDAVAE--MNYNNNNYNNNNNCSGLKNG-------------SGGGNSTVCK 383
            :..:||           :|:  ...|:.:....:..|.:|..             .......|..
Frog   353 DKSTAP-----------IAKPLATRNSESLPQEHKPSSVKPAQTVAVKESLSSDLQARKERDVSS 406

  Fly   384 TTPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHAR--FNFTYQPAGS 446
            ...:.::|.|.|:|:||||||||...:|:||||.|:|.:||:|||||||||:|  ||:.|.|  .
Frog   407 EPRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHP--K 469

  Fly   447 GARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLELD 511
            ||||||:||:.|||||||:|.|:....|.:|:|. |||:||.:|.::||||:|.|..:.||||.:
Frog   470 GARIDVSINECYDGSYAGNPQDIHRQPGFAFSRN-GPVKRTPITHILVCRPKRTKASMSEFLESE 533

  Fly   512 EDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKE 576
            :.|:..||:|.:||||||.|::||||:.|:|:|:|||.|.||.|||:|||..|:|||||||||||
Frog   534 DGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMDVDSEDEKDPEWLREKTITQIEEFSDVNEGEKE 598

  Fly   577 LMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKT 641
            :||:||||||:|||:.|.|:...|.:|:|..|.:|::|||.|||:||:.|:.|:.||:..|:.|.
Frog   599 VMKMWNLHVMKHGFIADNQMNHGCMLFVDNYGPQIIQKNLCRNFMLHLVSMHDFNLISITTIDKA 663

  Fly   642 VQKLQGLLSKYAAGQELMQR-QREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQA------S 699
            |.:|          :|:.|: :|:|.|                        |||:|:|      :
Frog   664 VSRL----------REIQQKVERDECL------------------------APPSDEAFEEPNRT 694

  Fly   700 TSSASTSGSGSGSS--------SMQPPKRMPAHLKR 727
            |||:|:....:|..        |.||||    |.|:
Frog   695 TSSSSSFMETNGKDRVVENDCVSGQPPK----HSKK 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)12	NP_730465.1	VEFS-Box	511..644	CDD:286776	75/132 (57%)
suz12	XP_012822185.1	Efa1_rel_toxin	329..>422	CDD:380310	19/107 (18%)
suz12	XP_012822185.1	VEFS-Box	532..666	CDD:370642	75/133 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1843
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32256
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1617
OMA	1	1.010	-	-		QHG49982
OrthoDB	1	1.010	-	-		D122694at33208
OrthoFinder	1	1.000	-	-		FOG0002735
OrthoInspector	1	1.000	-	-		otm47884
Panther	1	1.100	-	-	LDO	PTHR22597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4776
SonicParanoid	1	1.000	-	-		X2535
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110