Protein Alignment Su(z)12 and Suz12

DIOPT Version :10

• Sequence 1: NP_730465.1
• Gene: Su(z)12 / 48071
• FlyBaseID: FBgn0020887
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: NP_954666.1
• Gene: Suz12 / 52615
• MGIID: 1261758
• Length: 741
• Species: Mus musculus
• Alignment Length: 685
• Identity: 261/685 - (38%)
• Similarity: 386/685 - (56%)
• Gaps: 90/685 - (13%)

  Fly    28 APDASNAGSTVPPTAEGQVKLNGHQQEQELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKE 92
            |..|:.||:.|.|..  :.|:...|.:.|||||||||||||||:||.|:...||||:|||:||..
Mouse    60 AAAAAAAGAAVLPVK--KPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSH 122

  Fly    93 RMSRNNKKRISFQVNSMLESI-----TQKSEAVSQNYLHVIYDSLHEKLPARLDNESGEDLLQEQ 152
            |.||.:.||.:|:|:.||..:     .|:|.::|. :|.:.:.....|......|...|.
Mouse   123 RNSRTSIKRKTFKVDDMLSKVEKMKGEQESHSLSA-HLQLTFTGFFHKNDKPSQNSENEQ----- 181

  Fly   153 LLCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNP---KDRVGEHATISIPLQTMR 214
                  .||::|..|.|:...||||.:...:::.:...|:..||   :.:.|...::::......
Mouse   182 ------NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFE 240

  Fly   215 PMGEQHTL--YKLLFRIKVLSPSTCNDE-NAETPPN-----------KRSRPN-EKMFGSELILY 264
            | ...|.:  |.||||:........|.. |.||..|           ||:|.: ||.|.:::.::
Mouse   241 P-SNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRNREDGEKTFVAQMTVF 304

  Fly   265 EKSSGF-ITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPD-SYIPLSLTYDVYQQSPMLKFHLTL 327
            :|:... :.:||||..:|.:....|   |.|:.||||:.| ..:|   .::.:.|.|.|:|.|..
Mouse   305 DKNRRLQLLDGEYEVAMQEMEECPI---SKKRATWETILDGKRLP---PFETFSQGPTLQFTLRW 363

  Fly   328 ---SNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKNGSGGGNSTVC------- 382
               :|::....::.|...|             |:.:.:..|     |.||.....|:.
Mouse   364 TGETNDKSTAPVAKPLATR-------------NSESLHQEN-----KPGSVKPAQTIAVKETLTT 410

  Fly   383 -----------KTTPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHAR 436
                       ..:.:.::|.|.|:|:||||||||...:|:||||.|:|.:||:|||||||||:|
Mouse   411 ELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSR 475

  Fly   437 --FNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRR 499
              ||:.|.|  .||||||:||:.|||||||:|.|:....|.:|:|. |||:||.:|.::||||:|
Mouse   476 FIFNYVYHP--KGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRN-GPVKRTPITHILVCRPKR 537

  Fly   500 QKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMI 564
            .|..:.||||.::.|:..||:|.:||||||.|::||||:.|:|:::|||.|.||.|||:|||..|
Mouse   538 TKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQI 602

  Fly   565 DEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFD 629
            :|||||||||||:|||||||||:|||:.|.|:..||.:|::..|.:|::|||.|||:||:.|:.|
Mouse   603 EEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHD 667

  Fly   630 YGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQRE 664
            :.||:..::.|.|.||:.:..|...|:.......|
Mouse   668 FNLISIMSIDKAVTKLREMQQKLEKGESATPSNEE 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)12	NP_730465.1	ZnB-Zn_SUZ12-like	54..>82	CDD:459250	19/27 (70%)
		C2_II_SUZ12	154..328	CDD:467848	51/196 (26%)
		ZnB-Zn_SUZ12	<388..459	CDD:439246	43/72 (60%)
		VEFS-Box	511..644	CDD:462864	74/132 (56%)
Suz12	NP_954666.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Interaction with JARID2 and EPOP. /evidence=ECO:0000250|UniProtKB:Q15022	81..108		19/26 (73%)
		ZnB-Zn_SUZ12-like	84..>112	CDD:459250	19/27 (70%)
		Interaction with AEBP2 and PHF19. /evidence=ECO:0000250|UniProtKB:Q15022	148..365		58/235 (25%)
		C2_II_SUZ12	157..364	CDD:467848	55/225 (24%)
		ZnB-Zn_SUZ12	<425..498	CDD:439246	43/74 (58%)
		VEFS-box_SUZ12	565..686	CDD:439216	69/120 (58%)
		VEFS-box	565..641		50/75 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	689..741		3/14 (21%)