DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Su(z)12 and SUZ12

DIOPT Version :9

Sequence 1:NP_730465.1 Gene:Su(z)12 / 48071 FlyBaseID:FBgn0020887 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_056170.2 Gene:SUZ12 / 23512 HGNCID:17101 Length:739 Species:Homo sapiens


Alignment Length:810 Identity:283/810 - (34%)
Similarity:420/810 - (51%) Gaps:170/810 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GSAANGIIGLTHGAPDASN----AGSTVPPTAEGQVKLNGHQQEQELFLQAFEKPTQIYRYLRNR 75
            |.:..|  |.::.|..:|:    ||:.|.|..  :.|:...|.:.|||||||||||||||:||.|
Human    43 GGSCGG--GGSYSASSSSSAAAAAGAAVLPVK--KPKMEHVQADHELFLQAFEKPTQIYRFLRTR 103

  Fly    76 HETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESI-----TQKSEAVSQNYLHVIYDSLHEK 135
            :...||||:|||:||..|.||.|.||.:|:|:.||..:     .|:|.::|. :|.:.:.....|
Human   104 NLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSA-HLQLTFTGFFHK 167

  Fly   136 LPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNP---K 197
            ......|...|.           .||::|..|.|:...||||.:...:::.:...|:..||   :
Human   168 NDKPSPNSENEQ-----------NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQ 221

  Fly   198 DRVGEHATISIPLQTMRPMGEQHTL--YKLLFRIK---------VLSPSTCN--DENAETPP-NK 248
            .:.|...::::......| ...|.:  |.||||:.         :::..|..  |.|.|.|. .|
Human   222 TKPGNFPSLAVSSNEFEP-SNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRK 285

  Fly   249 RSRPN-EKMFGSELILYEKSSGF-ITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPD-SYIPLSL 310
            |:|.: ||.|.:::.:::|:... :.:||||..:|.:....|   |.|:.||||:.| ..:|   
Human   286 RNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPI---SKKRATWETILDGKRLP--- 344

  Fly   311 TYDVYQQSPMLKFHLTL---SNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKN 372
            .::.:.|.|.|:|.|..   :|::....|:.|...|             |:.:.:..|     |.
Human   345 PFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATR-------------NSESLHQEN-----KP 391

  Fly   373 GSGGGNSTVC--------------KTTP----EHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLD 419
            ||.....|:.              |.||    :.::|.|.|:|:||||||||...:|:||||.|:
Human   392 GSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLN 456

  Fly   420 CLRLYALLKHLKLCHAR--FNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCG 482
            |.:||:|||||||||:|  ||:.|.|  .||||||:||:.|||||||:|.|:....|.:|:|. |
Human   457 CRKLYSLLKHLKLCHSRFIFNYVYHP--KGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRN-G 518

  Fly   483 PVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDS 547
            ||:||.:|.::||||:|.|..:.||||.::.|:..||:|.:||||||.|::||||:.|:|:::||
Human   519 PVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDS 583

  Fly   548 EGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIV 612
            |.|.||.|||:|||..|:|||||||||||:|||||||||:|||:.|.|:..||.:|::..|.:|:
Human   584 EDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKII 648

  Fly   613 RKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLDVGMHK 677
            :|||.|||:||:.|:.|:.||:..::.|.|.||:.:..|...|:.                    
Human   649 KKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGES-------------------- 693

  Fly   678 KQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTE 742
                          |.||::..|.                                   :..||.
Human   694 --------------ASPANEEITE-----------------------------------EQNGTA 709

  Fly   743 NGTNGSNS-----SSSNSKNVAKKSADQPL 767
            ||.:..||     .:.:...|:|:|..|.|
Human   710 NGFSEINSKEKALETDSVSGVSKQSKKQKL 739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(z)12NP_730465.1 VEFS-Box 511..644 CDD:286776 74/132 (56%)
SUZ12NP_056170.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Interaction with JARID2 and EPOP. /evidence=ECO:0000269|PubMed:29499137 79..106 19/26 (73%)
Interaction with AEBP2 and PHF19. /evidence=ECO:0000269|PubMed:29499137 146..363 58/235 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..399 6/38 (16%)
VEFS-Box 546..680 CDD:401612 74/133 (56%)
VEFS-box 563..639 50/75 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..739 16/120 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155090
Domainoid 1 1.000 262 1.000 Domainoid score I1967
eggNOG 1 0.900 - - E1_KOG2350
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H32256
Inparanoid 1 1.050 435 1.000 Inparanoid score I1704
Isobase 1 0.950 - 0.831874 Normalized mean entropy S3651
OMA 1 1.010 - - QHG49982
OrthoDB 1 1.010 - - D122694at33208
OrthoFinder 1 1.000 - - FOG0002735
OrthoInspector 1 1.000 - - oto88994
orthoMCL 1 0.900 - - OOG6_106100
Panther 1 1.100 - - LDO PTHR22597
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4776
SonicParanoid 1 1.000 - - X2535
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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