Protein Alignment Su(z)12 and Su(z)12

DIOPT Version :10

• Sequence 1: NP_730465.1
• Gene: Su(z)12 / 48071
• FlyBaseID: FBgn0020887
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: XP_061516753.1
• Gene: Su(z)12 / 1280777
• VectorBaseID: AGAMI1_001420
• Length: 1005
• Species: Anopheles gambiae
• Alignment Length: 1064
• Identity: 353/1064 - (33%)
• Similarity: 515/1064 - (48%)
• Gaps: 276/1064 - (25%)

  Fly     1 MAPAKKREKDSNPDGSAANGIIGLTHGAPDASNAGSTV---------------------PPTAEG 44
            |....::..|.:|.|:..         .|.:|..|||.                     ||.||.
Mosquito     1 MEKQARKHPDVSPAGAGC---------VPSSSGGGSTSSKTKKNHPLRKKEKDTEVMGRPPRAET 56

  Fly    45 QVKLNGHQQEQELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSM 109
            ..      .:.|:|:|||||.|.|||:||.|:...||||:|.|:||:.||||::|.|.||:::||
Mosquito    57 LT------TDHEVFMQAFEKSTHIYRFLRTRNILKPIFLHRNLTYMRNRMSRSHKSRQSFKIDSM 115

  Fly   110 LESITQKSEAVSQN-------YLHVIYDSLHEKLPARLDNESGE-------------DLLQEQLL 154
            ||....|..:...|       ||.:::....::....:.|.:.:             |...::
Mosquito   116 LEKKVAKLRSEKANGLTMADGYLTLVFLGFFDEKNQTIRNGAADSNGIVVPLKNAFPDEPHDE-- 178

  Fly   155 CEAGES------VSVETTLYKITRSKRKDSTLDFQ-ELLSKCSQIVYNPKDR------------V 200
            .:.|.|      |.|||.|.||..:||||::...| :|....||::.||||.            :
Mosquito   179 ADIGASDCGRKCVQVETNLLKIAHTKRKDASAATQMQLTIGKSQVLVNPKDEQPAVEGGGSGGTL 243

  Fly   201 GEH---ATISIPLQTMRPMGEQHTL------YKLLFRIKVLSPS--------------------- 235
            |:.   ..:|||..|....|..:.:      :.|.||::..:|:
Mosquito   244 GQEEKPPIVSIPTDTFNTNGMVNQVAATQVSFVLRFRVQYTAPAGAGPGDTNGGEHNNYLTNSAG 308

  Fly   236 TCNDENAETPPNKRSR--PNEKMFGSELILYEK-SSGFITEGEYEAMLQPL----NSTSIKSFSP 293
            |.:|  .|.|..||.:  .:.|::.:||.:.:| ....:.:.:||..::.:    .:.:.|..||
Mosquito   309 TVSD--GEEPSAKRQKLHGHSKLYSTELTVCDKYGRCLLKQADYELTVREIISHQKTVAAKYGSP 371

  Fly   294 -KKCTWETMPDSY-----------------IPLSLTY-DVYQQ--SPMLKFHLTLSNEQLP---- 333
             |...|.:||::|                 .|.|..: |.|::  .|:||..|..:.|. |
Mosquito   372 IKNRYWSSMPEAYDIMDFLPSDDCAKGDVLPPTSEDFIDRYEEMIRPILKVRLLWTKEP-PRGYE 435

  Fly   334 ----------------EMISAPELQRYVQHLDAVAEMNYNNNNY--------------------- 361
                            |....|.|:.|.:.|:    :|.|||:.
Mosquito   436 PAGAAEIKLENGYSDKENHKPPSLEPYRKGLN----ININNNSILTPAAAAAGHPDEVEPSATAP 496

  Fly   362 ---------NNNNNCSGLKNGSGGGNSTVCKTTPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCG 417
                     ..:|....:.||...|.    |...:..:::|:|:::|.:||:||...:..||||.
Mosquito   497 GDEDTPMVDEKSNLAVVVSNGGEVGP----KKEEDGKRVIYHFIHNNYSRQRTETGDDYTCPWCS 557

  Fly   418 LDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCG 482
            |:|..||:|||||||||||.||.|.|...|||||||||:.|||||.|||:||.||:.:...|  .
Mosquito   558 LNCAVLYSLLKHLKLCHARLNFNYVPIPEGARIDVTINELYDGSYNGSPHDLLGPTTAYTVR--D 620

  Fly   483 PVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDS 547
            |:|||.||:|:||||||.|..|.||::.||:|..:||.|||||:|:||||.|||||:|:||||||
Mosquito   621 PMRRTVVTNLLVCRPRRPKPSLSEFIDNDENEFDSQRPYITGHSRMYHHTMTCLPVYPRELDIDS 685

  Fly   548 EGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIV 612
            |||||||||:|||:||||||:||||||||||||||||||::|:.||||:|||.|||:|.:|.|::
Mosquito   686 EGESDPLWLQQKTMQMIDEFTDVNEGEKELMKLWNLHVMKYGYSGDCQIPIALEMFIDLRGRELM 750

  Fly   613 RKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLDVGMHK 677
            .:||||||:||||||||:||::|:.:.:.::||:.:.:.....|:.::..|.||:.||.:|.:||
Mosquito   751 ARNLYRNFVLHMCSLFDFGLVSADVMQRIIRKLRKIPANDTELQQALKTARTEQMDYWNNVTVHK 815

  Fly   678 KQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTE 742
                |:|:|:..:   ......|:.|..|.|.||.||.|       |.|.|
Mosquito   816 ----PQTIKTEHR---NGGGERTAGAGASTSISGISSYQ-------HHKSG-------------- 852

  Fly   743 NGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDNT 807
            :|..||.:|::..                         ||:|.|   :...|||     .:.|..
Mosquito   853 HGVGGSGTSTTGD-------------------------GQQRKV---KPTITPA-----KNTDPG 884

  Fly   808 VLNKRQRYSDGSPGTGIGNGHGGGSGSGANRNKSNNHS-----------LPATSNNASSSSSNSK 861
            ..::|:|      ..|..|.:.|||||.::..|:...|           .|:.|....||||::.
Mosquito   885 EHSRRRR------SAGNANKNTGGSGSHSSAGKATTSSGSPHSTTAGLKAPSGSGKTPSSSSSTA 943

  Fly   862 RAIARRRSTSERTKASGSTGGGAG 885
            .|...|:|:|.:..||.:....:|
Mosquito   944 NAAGGRKSSSTKLFASPTALSASG 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)12	NP_730465.1	ZnB-Zn_SUZ12-like	54..>82	CDD:459250	15/27 (56%)
		C2_II_SUZ12	154..328	CDD:467848	59/250 (24%)
		ZnB-Zn_SUZ12	<388..459	CDD:439246	39/70 (56%)
		VEFS-Box	511..644	CDD:462864	94/132 (71%)
Su(z)12	XP_061516753.1	None