DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP1A4 and Atpalpha

DIOPT Version :9

Sequence 1:NP_653300.2 Gene:ATP1A4 / 480 HGNCID:14073 Length:1029 Species:Homo sapiens
Sequence 2:NP_732572.1 Gene:Atpalpha / 48971 FlyBaseID:FBgn0002921 Length:1041 Species:Drosophila melanogaster


Alignment Length:1023 Identity:725/1023 - (70%)
Similarity:849/1023 - (82%) Gaps:2/1023 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     9 TVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSH 73
            ||...|...|....:...::||..:..:|.|:::||:|:.:|.||::.|||..::......|.||
  Fly    19 TVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSH 83

Human    74 QRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNL 138
            .:|||.|.|.|||.:|||..|||||||||.|||||::|||.||||||||||||...:|||..|||
  Fly    84 AKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNL 148

Human   139 YLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKG 203
            ||.||||.||||||.||||||:|||||||||||||||.|.|||.|||:.:..:::||||:||:|.
  Fly   149 YLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKF 213

Human   204 GDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIA 268
            |||:|||:|:|.|:..||||||||||||||||..:|||||||||:|:.|||||.|||||:|:||:
  Fly   214 GDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVIS 278

Human   269 TGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLI 333
            .||.|||||||.|.|||..|:||||.||.|||||||.||||||||||.::.:|||.||:|:||||
  Fly   279 CGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLI 343

Human   334 GIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 398
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
  Fly   344 GIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 408

Human   399 MWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESA 463
            ||||..:.||||||:|:|..:.::|..:..|:|||.|||||:||..|:.:||.|:..:|||||:|
  Fly   409 MWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAA 473

Human   464 LLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQ-THVLMMKGAPERILEFCST 527
            |||.:|.:...|..:|::|.|:||:|||||||||:|||..||::. .::|:||||||||||.|||
  Fly   474 LLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCST 538

Human   528 FLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPS-SFSKGFPFNTDEINFPMDNLCF 591
            ..:||:|..:::||||||.|||:|||||||||||||...||| .:..||.||||:||||:|||.|
  Fly   539 IFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRF 603

Human   592 VGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKI 656
            |||:||||||||||||||:|||||||||||||||||||||||||.|||||||.||.|::|.||.|
  Fly   604 VGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNI 668

Human   657 PISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVT 721
            |:|:|:...|||.|||||||:|:.|.|||:||:.|.|||||||||||||||||||||:||:||||
  Fly   669 PVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVT 733

Human   722 GDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTL 786
            ||||||||||||||||:||||:|||||||||||||||||||||||||||||||||||||||.|||
  Fly   734 GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL 798

Human   787 TSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLV 851
            |||||||:|||.||:..|||||||:||||||||||||||||||||.||:|||||.||:|..|.||
  Fly   799 TSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLV 863

Human   852 NHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQ 916
            |.|||.|||||||||||.||||.||||:|||||.|..|.|||..|:.|.:|||.|||||:|||..
  Fly   864 NSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRD 928

Human   917 RKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMD 981
            ||.:|:||.||||::|||||||||||.||||||:|||||||..|.||::.||:|||||||.|||:
  Fly   929 RKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGME 993

Human   982 VALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY 1029
            ..|||||||:.||..|||:::.||:|||.|:..:|::|.||:|:||||
  Fly   994 KGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP1A4NP_653300.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 6/27 (22%)
ATPase-IIC_X-K 35..1029 CDD:273445 717/995 (72%)
Cation_ATPase_N 49..122 CDD:214842 43/72 (60%)
Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250 90..92 1/1 (100%)
E1-E2_ATPase 154..373 CDD:278548 167/218 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..242 15/18 (83%)
Cation_ATPase 435..527 CDD:289987 53/92 (58%)
COG4087 609..758 CDD:226572 121/148 (82%)
Cation_ATPase_C 805..1014 CDD:279079 151/208 (73%)
AtpalphaNP_732572.1 ATPase-IIC_X-K 45..1041 CDD:273445 717/995 (72%)
Cation_ATPase_N 58..132 CDD:214842 43/73 (59%)
E1-E2_ATPase 152..383 CDD:278548 177/230 (77%)
Cation_ATPase 445..539 CDD:289987 54/93 (58%)
COG4087 <695..770 CDD:226572 66/74 (89%)
Cation_ATPase_C 817..1025 CDD:279079 151/207 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 333 1.000 Domainoid score I1130
eggNOG 1 0.900 - - E2759_KOG0203
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D388324at2759
OrthoFinder 1 1.000 - - FOG0000283
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100215
Panther 1 1.100 - - O PTHR43294
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X416
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.790

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