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Protein Alignment ACO1 and mAcon1

DIOPT Version :9

Sequence 1:	NP_001265281.1	Gene:	ACO1 / 48	HGNCID:	117	Length:	889	Species:	Homo sapiens
Sequence 2:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	918	Identity:	239/918 - (26%)
Similarity:	375/918 - (40%)	Gaps:	234/918 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    24 LNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI------------ENILHWNVTQHKNIEV 76
            |:|.:...|  ||:              |.|.|:.::            |.:|:.::....|.::
  Fly    41 LSKFDSDVY--LPY--------------EKLNKRLEVVRGRLNRPLTLSEKVLYSHLDDPANQDI 89

Human    77 -------PFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNR 134
                   ..:|.||.:||.|...|::.|  :...:||:         ..|:.:..||.|:.....
  Fly    90 VRGTSYLRLRPDRVAMQDATAQMALLQF--ISSGLKKV---------AVPSTVHCDHLIEAQIGG 143

Human   135 RADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPD 199
            ..| |.:.:||    |:|.::||. .:.|.:.:....||||||||:.||          .|.:|.
  Fly   144 PKD-LARAKDL----NKEVYDFLA-STCAKYGLGFWKPGSGIIHQIILE----------NYAFPG 192

Human   200 SL-VGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLT 263
            .| :||||||....|||.|..||||.:|..||...|..:..|:|||..|.||.....:..|::|.
  Fly   193 LLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILK 257

Human   264 ITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGR--- 325
            :...|...|..|..:|:.|.||..:|....|||.||..|.|||.:.||.::....||..|||
  Fly   258 VADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGI 322

Human   326 DEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFE 390
            ..|..||..|.|.|          .::.::.:::|::|.|:.|..:||..|.....:|.
  Fly   323 ASEAQKYQAKILSA----------DKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISK------ 371

Human   391 SCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKK 455
              ||......|:.:                       .:.:..|.||||:|... |.....:||.
  Fly   372 --LGENSKKNGYPM-----------------------DIRVGLIGSCTNSSYED-MGRCASIAKD 410

Human   456 AVDAGL-NVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVE 519
            |:..|| :.:|:   :::|||..:...::..|:.....:.|..|:...|..|||....      :
  Fly   411 AMSHGLKSKIPF---NVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDR------K 466

Human   520 AITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLG---VNA 579
            .:.:||...: |.|.||||.||  .:|.|.. ::.||.||.|.:|||  |:||  .||.   ..|
  Fly   467 DVKKGDKNTI-VTSYNRNFTGRNDANPATHC-FVTSPELVTALSIAG--RLDF--NPLTDELTGA 525

Human   580 KGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK 644
            .|::..||.  |..||:.|   :...||                               :.||..
  Fly   526 DGKKFKLKA--PFGDELPA---KGFDPG-------------------------------QDTYTA 554

Human   645 SPPFFENLTLDLQPP---------------KSIVDAYVLLNLGDSVTTDHISPAG---------- 684
            .||..||:.:.:.|.               :.:.|..||:.:....||||||.||
  Fly   555 PPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLD 619

Human   685 NIARNS--PAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSG 747
            ||:.|.  .|..|..|      |.|:..::|       .|::..:.
  Fly   620 NISNNMFIGATNYENN------EMNNIKNQR-------NGSWGGVP------------------- 652

Human   748 EILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMG 812
                  |.|..|:..|:..:.:..:.||.||||:.||..|..||.:|::.:|:.|||.:||...|
  Fly   653 ------DVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQG 711

Human   813 VIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDT--DVELTYFL 875
            ::||.:....:.|.:..|  .:.:::..::|.|...|..::..|...:.:....|  |:::.:|.
  Fly   712 LLPLTFANPADYDKIQPT--SKISLLNLKSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFK 774

Human   876 NGGILNYM 883
            .|..||.|
  Fly   775 AGSALNRM 782

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.