Protein Alignment ACO1 and mAcon1

DIOPT Version :10

• Sequence 1: XP_047279386.1
• Gene: ACO1 / 48
• HGNCID: 117
• Length: 897
• Species: Homo sapiens
• Sequence 2: NP_524708.1
• Gene: mAcon1 / 44149
• FlyBaseID: FBgn0010100
• Length: 787
• Species: Drosophila melanogaster
• Alignment Length: 918
• Identity: 239/918 - (26%)
• Similarity: 375/918 - (40%)
• Gaps: 234/918 - (25%)

Human    32 LNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI------------ENILHWNVTQHKNIEV 84
            |:|.:...|  ||:              |.|.|:.::            |.:|:.::....|.::
  Fly    41 LSKFDSDVY--LPY--------------EKLNKRLEVVRGRLNRPLTLSEKVLYSHLDDPANQDI 89

Human    85 -------PFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNR 142
                   ..:|.||.:||.|...|::.|  :...:||:         ..|:.:..||.|:.....
  Fly    90 VRGTSYLRLRPDRVAMQDATAQMALLQF--ISSGLKKV---------AVPSTVHCDHLIEAQIGG 143

Human   143 RADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPD 207
            ..| |.:.:||    |:|.::||. .:.|.:.:....||||||||:.||          .|.:|.
  Fly   144 PKD-LARAKDL----NKEVYDFLA-STCAKYGLGFWKPGSGIIHQIILE----------NYAFPG 192

Human   208 SL-VGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLT 271
            .| :||||||....|||.|..||||.:|..||...|..:..|:|||..|.||.....:..|::|.
  Fly   193 LLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILK 257

Human   272 ITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGR--- 333
            :...|...|..|..:|:.|.||..:|....|||.||..|.|||.:.||.::....||..|||
  Fly   258 VADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGI 322

Human   334 DEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFE 398
            ..|..||..|.|.|          .::.::.:::|::|.|:.|..:||..|.....:|.
  Fly   323 ASEAQKYQAKILSA----------DKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISK------ 371

Human   399 SCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKK 463
              ||......|:.:                       .:.:..|.||||:|... |.....:||.
  Fly   372 --LGENSKKNGYPM-----------------------DIRVGLIGSCTNSSYED-MGRCASIAKD 410

Human   464 AVDAGL-NVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVE 527
            |:..|| :.:|:   :::|||..:...::..|:.....:.|..|:...|..|||....      :
  Fly   411 AMSHGLKSKIPF---NVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDR------K 466

Human   528 AITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLG---VNA 587
            .:.:||...: |.|.||||.||  .:|.|.. ::.||.||.|.:|||  |:||  .||.   ..|
  Fly   467 DVKKGDKNTI-VTSYNRNFTGRNDANPATHC-FVTSPELVTALSIAG--RLDF--NPLTDELTGA 525

Human   588 KGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK 652
            .|::..||.  |..||:.|   :...||                               :.||..
  Fly   526 DGKKFKLKA--PFGDELPA---KGFDPG-------------------------------QDTYTA 554

Human   653 SPPFFENLTLDLQPP---------------KSIVDAYVLLNLGDSVTTDHISPAG---------- 692
            .||..||:.:.:.|.               :.:.|..||:.:....||||||.||
  Fly   555 PPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLD 619

Human   693 NIARNS--PAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSG 755
            ||:.|.  .|..|..|      |.|:..::|       .|::..:.
  Fly   620 NISNNMFIGATNYENN------EMNNIKNQR-------NGSWGGVP------------------- 652

Human   756 EILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMG 820
                  |.|..|:..|:..:.:..:.||.||||:.||..|..||.:|::.:|:.|||.:||...|
  Fly   653 ------DVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQG 711

Human   821 VIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDT--DVELTYFL 883
            ::||.:....:.|.:..|  .:.:::..::|.|...|..::..|...:.:....|  |:::.:|.
  Fly   712 LLPLTFANPADYDKIQPT--SKISLLNLKSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFK 774

Human   884 NGGILNYM 891
            .|..||.|
  Fly   775 AGSALNRM 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACO1	XP_047279386.1	PTZ00092	10..897	CDD:240263	239/918 (26%)
mAcon1	NP_524708.1	aconitase_mito	52..782	CDD:273561	233/903 (26%)