DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rin and G3BP2

DIOPT Version :9

Sequence 1:	NP_524907.2	Gene:	rin / 47998	FlyBaseID:	FBgn0015778	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_036429.2	Gene:	G3BP2 / 9908	HGNCID:	30291	Length:	482	Species:	Homo sapiens

Alignment Length:	688	Identity:	216/688 - (31%)
Similarity:	293/688 - (42%)	Gaps:	233/688 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVMDATQSQQPSPQSVGREFVRQYYTLLNKAPNHLHRFYNHNSSYIHG-------ESKLVVGQRE 58
            |||     ::|||..|||||||||||||||||.:|||||..||||:||       ..:.|.||.:
Human     1 MVM-----EKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQND 60

  Fly    59 IHNRIQQLNFNDCHAKISQVDAQATLGNGVVVQVTGELSNDGQPMRRFTQTFVLAAQS--PKKYY 121
            ||:::..|||::||.||..|||.|||.:||||||.|.|||.|||.|:|.||||||.:.  |.|:|
Human    61 IHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPNKFY 125

  Fly   122 VHNDIFRYQDLYIEDEQDGESRSENDEEHDVQVVGGTVDQAVQVAGDVVAQQPQQQQAPPQPQAQ 186
            ||||:|||     |||..|:|..|.|||.:                |.|.::.:::|..|:|..:
Human   126 VHNDMFRY-----EDEVFGDSEPELDEESE----------------DEVEEEQEERQPSPEPVQE 169

  Fly   187 VVVP--QQVAPVAAGGAAP--QQIFYPLPAGAAAGRPVAVLPPAPQAAAVPLPAQFTVPPP-QPI 246
            ....  .:..||..|...|  :....|.|...:..:...:.|...:.....|..:.|.||| :|:
Human   170 NANSGYYEAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKNLEELEEKSTTPPPAEPV 234

  Fly   247 QNGVVSHEELQQQQVLVPPS----VSPLVQQQQPTGTPVLPIVPVPSAGFQQSPLVAPQLIQQQQ 307
                    .|.|:    ||.    .|...:...|:||       |.|:|
Human   235 --------SLPQE----PPKAFSWASVTSKNLPPSGT-------VSSSG---------------- 264

  Fly   308 QQQPAQLPPQQQQQQQPIQQQQPLQQQQQPLAEPEEVEVAPR-QQKPPTPVEDFKTIHEQQQQEK 371
                  :||                ..:.|:::| .||..|. |.:||       .:.||:.:|:
Human   265 ------IPP----------------HVKAPVSQP-RVEAKPEVQSQPP-------RVREQRPRER 299

  Fly   372 YEAAKQQQNEPKTYANLFKSTSSSPSGFVNAALQQQQQLQQQQQQQQSISSNTYNSSSATSGGGN 436
                                     .||
Human   300 -------------------------PGF------------------------------------- 302

  Fly   437 GSQVSYSTTASSYNNSNGNSRLDNGGPLPQRNNSIRNNKGDFEQRRSSNTQ--QFGDNQQLFLGN 499
                                  ...||.|.|        ||.||..|.|.:  ::.|:.|||:||
Human   303 ----------------------PPRGPRPGR--------GDMEQNDSDNRRIIRYPDSHQLFVGN 337

  Fly   500 IPHHASEDDLREIFSRFGNVLELRILSK-AGNKVPPGMRSPLNYGFITYDDPEAVQKCLANCPLY 563
            :||...|::|:|.|..||||:||||.:| .|.|:|       |:||:.:||.|.||:.|...|:.
Human   338 LPHDIDENELKEFFMSFGNVVELRINTKGVGGKLP-------NFGFVVFDDSEPVQRILIAKPIM 395

  Fly   564 FPENSPDGQ-KLNVEEKKPRVRNDMVPRQQIGGNNLNNNMGRLGGNNGPQSRPMGNNNG-SGGGM 626
            |     .|: :|||||||.|...:   |:..||.:...::.|  .:.||     |...| .||||
Human   396 F-----RGEVRLNVEEKKTRAARE---RETRGGGDDRRDIRR--NDRGP-----GGPRGIVGGGM 445

  Fly   627 MRNNAGGNNLRQGGGGGNGAPRLGGGGGFGQRQDNRTG 664
            ||:..|.....:||    .|.:||.|.|.||.:...||
Human   446 MRDRDGRGPPPRGG----MAQKLGSGRGTGQMEGRFTG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rin	NP_524907.2	NTF2	12..131	CDD:238403	79/127 (62%)
		RRM	423..>557	CDD:223796	42/136 (31%)
		RRM_G3BP	490..580	CDD:240675	41/91 (45%)
G3BP2	NP_036429.2	NTF2	7..135	CDD:238403	79/132 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..172		10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..318		44/287 (15%)
		RRM_G3BP2	326..408	CDD:409897	41/93 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..482		28/86 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159140
Domainoid	1	1.000	157	1.000	Domainoid score	I4157
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53615
OrthoDB	1	1.010	-	-		D1526879at2759
OrthoFinder	1	1.000	-	-		FOG0000749
OrthoInspector	1	1.000	-	-		otm41493
orthoMCL	1	0.900	-	-		OOG6_102794
Panther	1	1.100	-	-	O	PTHR10693
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.860