DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rin and g3bp2

DIOPT Version :9

Sequence 1:	NP_524907.2	Gene:	rin / 47998	FlyBaseID:	FBgn0015778	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_989273.1	Gene:	g3bp2 / 394887	XenbaseID:	XB-GENE-480361	Length:	484	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	205/698 - (29%)
Similarity:	289/698 - (41%)	Gaps:	253/698 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVMDATQSQQPSPQSVGREFVRQYYTLLNKAPNHLHRFYNHNSSYIHG-------ESKLVVGQRE 58
            |||     ::|||..|||||||||||||||||:.|||||..||||:||       ..:.|.||.|
Frog     1 MVM-----EKPSPLLVGREFVRQYYTLLNKAPDFLHRFYGRNSSYVHGGLDATGKPQEAVYGQAE 60

  Fly    59 IHNRIQQLNFNDCHAKISQVDAQATLGNGVVVQVTGELSNDGQPMRRFTQTFVLAAQS--PKKYY 121
            ||.::..|.|::|..||..|||.|||.:||||||.|||||:|||||:|.||||||.:.  |.|:|
Frog    61 IHKKVMSLQFSECRTKIRHVDAHATLSDGVVVQVMGELSNNGQPMRKFMQTFVLAPEGSVPNKFY 125

  Fly   122 VHNDIFRYQDLYIEDEQDGESRSENDEEHDVQVVGGTVDQAVQVAGDVVAQQPQQQQAPPQPQAQ 186
            ||||||||     |||..|:|.:|.|||.:.:|                  :.:|::..|.|:
Frog   126 VHNDIFRY-----EDEVFGDSEAEMDEESEEEV------------------EEEQEERQPSPE-- 165

  Fly   187 VVVPQQVAPVAAGGAAPQQIFYPLPAGAAAGRPVAVLPPAPQAAAVPLPAQFTVPPPQPIQNGVV 251
                                    ||......  |...|.|.:..|..|.:..|..|:|.....:
Frog   166 ------------------------PAQENTNN--AYYEPHPVSNGVEEPLEEPVNEPEPEPEPEI 204

  Fly   252 SHEELQ-----------QQQVLVPPSVSPLVQQQQP---------TGTPVLPIVPVPSAGFQQSP 296
            .:||::           :::...||...|:|..|:|         |...:.|...||::|
Frog   205 KNEEIKPETEEKVQEELEEKSPTPPPAEPVVLPQEPPKAFSWASVTSKNLPPSGTVPASG----- 264

  Fly   297 LVAPQLIQQQQQQQPAQLPPQQQQQQQPIQQQQPLQQQQQPLAEPEEVEVAPRQQKPPTPVEDFK 361
             :.|.:|:....|....:.|:...|...:::|:|   :::|..:|.    .||.
Frog   265 -IPPHVIKAPASQARVDVKPEAPAQSLRVREQRP---RERPAFQPR----GPRV----------- 310

  Fly   362 TIHEQQQQEKYEAAKQQQNEPKTYANLFKSTSSSPSGFVNAALQQQQQLQQQQQQQQSISSNTYN 426

Frog   311 ----------------------------------------------------------------- 310

  Fly   427 SSSATSGGGNGSQVSYSTTASSYNNSNGNSRLDNGGPLPQRNNSIRNNKGDFEQRRSSNTQ--QF 489
                   ||                     |.||                  ||..|.|.:  ::
Frog   311 -------GG---------------------RSDN------------------EQSESDNRRMYRY 329

  Fly   490 GDNQQLFLGNIPHHASEDDLREIFSRFGNVLELRILSK-AGNKVPPGMRSPLNYGFITYDDPEAV 553
            .|:.|||:||:||...|.:|:|.|..:|||:||||.:| .|.|:|       |:||:.:||.|.|
Frog   330 PDSHQLFVGNLPHDIDESELKEFFMSYGNVMELRINTKGVGGKLP-------NFGFVVFDDSEPV 387

  Fly   554 QKCLANCPLYFPENSPDGQ-KLNVEEKKPRVRNDMVPRQQIGGNNLNNNMGRLGGNNGPQSRPMG 617
            |:.|.:.|:.|     .|: :|||||||.|...:   |:..||::..:......|..||:..
Frog   388 QRILLSKPIMF-----RGEVRLNVEEKKTRAARE---RETRGGDDRRDIRRNDRGPGGPRGL--- 441

  Fly   618 NNNGSGGGMMRNNAG------GNNLRQGGGGGNGAPRLGGGGGFGQRQ 659
                ..|||:|:..|      |..:::.|.|..|||.:.|... |||:
Frog   442 ----ISGGMVRDRDGRGPPPRGGMVQKLGSGRGGAPPVEGRFS-GQRR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rin	NP_524907.2	NTF2	12..131	CDD:238403	81/127 (64%)
		RRM	423..>557	CDD:223796	40/136 (29%)
		RRM_G3BP	490..580	CDD:240675	40/91 (44%)
g3bp2	NP_989273.1	NTF2	7..135	CDD:238403	81/132 (61%)
		PRK14951	<210..>326	CDD:237865	31/250 (12%)
		RRM_G3BP2	328..410	CDD:240910	40/93 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4010
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1526879at2759
OrthoFinder	1	1.000	-	-		FOG0000749
OrthoInspector	1	1.000	-	-		otm48702
Panther	1	1.100	-	-	O	PTHR10693
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.110