DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rin and G3BP1

DIOPT Version :9

Sequence 1:	NP_524907.2	Gene:	rin / 47998	FlyBaseID:	FBgn0015778	Length:	690	Species:	Drosophila melanogaster
Sequence 2:	NP_005745.1	Gene:	G3BP1 / 10146	HGNCID:	30292	Length:	466	Species:	Homo sapiens

Alignment Length:	678	Identity:	211/678 - (31%)
Similarity:	288/678 - (42%)	Gaps:	243/678 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVMDATQSQQPSPQSVGREFVRQYYTLLNKAPNHLHRFYNHNSSYIHG-------ESKLVVGQRE 58
            |||     ::|||..||||||||||||||:||:.|||||..||||:||       .:..|.||:|
Human     1 MVM-----EKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 60

  Fly    59 IHNRIQQLNFNDCHAKISQVDAQATLGNGVVVQVTGELSNDGQPMRRFTQTFVLAAQS--PKKYY 121
            ||.::...||.:||.||..|||.|||.:||||||.|.|||:.|.:|||.||||||.:.  ..|:|
Human    61 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFY 125

  Fly   122 VHNDIFRYQD-----LYIEDEQDGESRSENDEEHD--VQVV----GGTVDQAVQVAGDVV--AQQ 173
            ||||||||||     ...|.:::.|...|..||..  .:||    |...|||| |:.|:.  .::
Human   126 VHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAV-VSNDMEEHLEE 189

  Fly   174 PQQQQAP-PQPQAQVVVPQQVAPVAAGGAAPQQIFYPLPAGAAAGRPVAVL----PPAPQAAAVP 233
            |..:..| |:|:     |:| .||:.               ....:|..||    |...|.::.|
Human   190 PVAEPEPDPEPE-----PEQ-EPVSE---------------IQEEKPEPVLEETAPEDAQKSSSP 233

  Fly   234 LPAQFTVPPPQPIQNGVVSHEELQQQQVLVPPSVSPLVQQQQPTGTPVLP-IVPVPSAGFQQSPL 297
            .||...    |.:|..:.:..........:|||.:..|     ||.|  | :|.||::  |..|.
Human   234 APADIA----QTVQEDLRTFSWASVTSKNLPPSGAVPV-----TGIP--PHVVKVPAS--QPRPE 285

  Fly   298 VAPQLIQQQQQQQPAQLPPQQQQQQQPIQQQQPLQQQQQPLAEPEEVEVAPRQQKPPTPVEDFKT 362
            ..|:          :|:|||:.|:.|.:::|:              :.:.|  |:.|.|:.
Human   286 SKPE----------SQIPPQRPQRDQRVREQR--------------INIPP--QRGPRPIR---- 320

  Fly   363 IHEQQQQEKYEAAKQQQNEPKTYANLFKSTSSSPSGFVNAALQQQQQLQQQQQQQQSISSNTYNS 427
                      ||.:|
Human   321 ----------EAGEQ-------------------------------------------------- 325

  Fly   428 SSATSGGGNGSQVSYSTTASSYNNSNGNSRLDNGGPLPQRNNSIRNNKGDFEQRRSSNTQQFGDN 492
                                                            ||.|.||   ..:..|:
Human   326 ------------------------------------------------GDIEPRR---MVRHPDS 339

  Fly   493 QQLFLGNIPHHASEDDLREIFSRFGNVLELRILSKAGNKVPPGMRSPLNYGFITYDDPEAVQKCL 557
            .|||:||:||...:.:|::.|..:|||:||||  .:|.|:|       |:||:.:||.|.|||.|
Human   340 HQLFIGNLPHEVDKSELKDFFQSYGNVVELRI--NSGGKLP-------NFGFVVFDDSEPVQKVL 395

  Fly   558 ANCPLYFPENSPDGQ-KLNVEEKKPRVRNDMVPRQQIGGNNLNNNMGRLGGNNGPQSRPMGNNNG 621
            :|.|:.|     .|: :|||||||.|...:        |:..:|   ||.|..||:       .|
Human   396 SNRPIMF-----RGEVRLNVEEKKTRAARE--------GDRRDN---RLRGPGGPR-------GG 437

  Fly   622 SGGGMMRNNAGGNNLRQGGGGGNG-APR 648
            .||||.....||...:.|.|.|.| |||
Human   438 LGGGMRGPPRGGMVQKPGFGVGRGLAPR 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rin	NP_524907.2	NTF2	12..131	CDD:238403	77/127 (61%)
		RRM	423..>557	CDD:223796	34/133 (26%)
		RRM_G3BP	490..580	CDD:240675	39/90 (43%)
G3BP1	NP_005745.1	NTF2	7..135	CDD:238403	77/127 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..172		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..243		17/83 (20%)
		NESP55	<212..320	CDD:115071	35/146 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..329		30/220 (14%)
		RRM_G3BP1	337..416	CDD:240909	41/92 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..466		24/71 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159139
Domainoid	1	1.000	157	1.000	Domainoid score	I4157
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3606
OMA	1	1.010	-	-		QHG53615
OrthoDB	1	1.010	-	-		D1526879at2759
OrthoFinder	1	1.000	-	-		FOG0000749
OrthoInspector	1	1.000	-	-		otm41493
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R463
SonicParanoid	1	1.000	-	-		X634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.940