DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scat and vps54

DIOPT Version :9

Sequence 1:	NP_524905.1	Gene:	scat / 47942	FlyBaseID:	FBgn0011232	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001124248.1	Gene:	vps54 / 562169	ZFINID:	ZDB-GENE-081022-176	Length:	998	Species:	Danio rerio

Alignment Length:	1058	Identity:	348/1058 - (32%)
Similarity:	523/1058 - (49%)	Gaps:	209/1058 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GNSGIRKLSTASVGGIAGG---------VAPSWQSCYYCTREHFKSISDFVNHLRNRHCTRE--- 73
            |:|.|.:.|.|. ||.:.|         :||.    :|.|.   :|:.|.        |.:|
Zfish     6 GSSPIPQCSGAG-GGTSDGFFRKHREPPLAPK----HYRTA---RSLPDV--------CPKEPTG 54

  Fly    74 -GGSFVCRYGFNGVCASLPLDGVSDRDYDAHVAKYHVNQHTREMPPEWGVYSAAQNLPAVLNDPS 137
             ||         |:|     :|.|      .||..|          .|.||::..||||.||||.
Zfish    55 DGG---------GLC-----EGPS------VVADQH----------RWTVYNSKVNLPAALNDPR 89

  Fly   138 RGK-QSNLFTKKWGEHFVERSHVPPSPRLPDITHADFTVYLGSIGKRYRWHERRQQQLERDKPLE 201
            ..| :|:.|||.||..|.| :.|.||..||:||...|:.||....:|.:.|||          .:
Zfish    90 LAKRESDFFTKTWGLDFSE-TEVMPSFYLPNITREHFSSYLQDTAQREKIHER----------CK 143

  Fly   202 NGAQGAPGPGTGGQTPTH------LSSVPEIFLKSQLQLHHPATFKQVFP-NYMQTSASSPESHQ 259
            |.............|..|      |..||:||:|.:..|:.||||..|.| ::...:........
Zfish   144 NICPSKDDLSVSSITNNHEKARAELEQVPKIFMKPEFVLNDPATFNAVLPWSHFSVAGGKNSRDV 208

  Fly   260 QTGRQLQEQLSHYLDMVEVKIAQQVSQKSAAFFHAMTTQHAILAEMEQAADQVRQLRAALAELHS 324
            .:.|.|||:||||||:|||.||:|:|.:|.||||||::||.:..::.:.||.|.:|||..|.:..
Zfish   209 ASSRLLQEKLSHYLDVVEVSIARQISLRSEAFFHAMSSQHELQDQLRETADAVAKLRARTAAIDR 273

  Fly   325 HSVVDSFKVLRFAQRRQHYNLTLDKLRLMATVHKTQPMLQLLLGTQDYVAALDLIGTTQEILSAE 389
            .......:|||.|..|.:.....:||:|||.||:|||.:||||.|.::|.||:||.||:|:|..|
Zfish   274 VMCRGPLRVLRDALTRNNCIKLHNKLKLMAAVHQTQPTVQLLLSTSEFVGALELIATTKEVLQQE 338

  Fly   390 LLGIHCFKHLPMQLSEMEKLIDKMLTTEFERYAAADLNRPLTDALRETDSVCAEEDKLVAIVMGL 454
            |.|||.|:||..||.|||:|||||:..:|..||.:||:|..     |.|....|:|:|.::|.||
Zfish   339 LQGIHSFRHLGSQLCEMERLIDKMMVADFSTYAQSDLSRTF-----EEDGQVLEKDRLQSLVFGL 398

  Fly   455 LRKQNFSFVQAYQQEAIATIRAIIKQLLIEVLARSDSDQEISLTGHGEQALELTLPEWIALLQRS 519
            ||::...|:..|.:|.|...:.:::|.:::.|::.:.....::..| ||...:....|..||...
Zfish   399 LRQRKLDFLDIYSEEMIRAAKNVVRQCVVKSLSQVNEVDADTVRIH-EQMRLMAFHHWFDLLLDI 462

  Fly   520 SQALVSILERIKTVVGIMQ-------------QTADAAVGA------------------------ 547
            .:..:..|:|||..:|:::             :.|||....
Zfish   463 FEHFILFLKRIKATLGVIRNVVLEVLDSSQRSRLADATTATSHPDGRVNEDEEEESGGPALHPGE 527

  Fly   548 -------------QDAVNLID------------------------------SEAFLSPGHHE--- 566
                         .||:|..:                              :|:..|..|:.
Zfish   528 AELAYLTHEGLFISDALNDAEQRSVTTAAQTQTRAQTPRADACGSDSASATTESSSSREHNSNTT 592

  Fly   567 ---------------------QLKNQLQQLLQAVCHYCHERCANIVSPQ----SLERSSASEQEL 606
                                 ::.|.:|:||.|.....|:||..::..:    ||||.|:|  |.
Zfish   593 SCLPVGAAALEDVMPSDLELGRVANNVQELLYAASDVSHDRCVKVLMTRAKDGSLERLSSS--EF 655

  Fly   607 FQLSEIVDHFGETTRSICGVASVPLQLALKVQASRYAQRFHSERKQKLSLLLDQERWRQVDIPHE 671
            ..||:.|:.|.:.|..:||..||.|:.||:.||:|:.||||.|||.|||||||.|||:|.::|.|
Zfish   656 VCLSQAVESFVKDTEELCGRRSVSLRGALQSQANRFVQRFHEERKTKLSLLLDNERWKQAEVPAE 720

  Fly   672 FQRIIERMAAGDYAKPEMGNLISNGAGNPV--LLVEGKQPYTLVSASLMLIRMLYEYGCSAHRLP 734
            ||.:::.:|.|..:.||..:...:....|.  |.|:| |.|.:|...|:||||..||....:.:|
Zfish   721 FQDLVDSIADGRISLPERKHSSGSEDRKPTEFLCVDG-QKYAVVGTVLLLIRMFLEYCQCVNDIP 784

  Fly   735 LLASYHARNVVDLLRCFNSRSCQLIIGAGAMRVAGLKTITSTNLALVSRALQLVLWLLPKLKEHF 799
            .:.:.....:.|||:.||||.|||::||||::..||||||:.||||.||.||||:..:|.::.||
Zfish   785 SITTDIITRLADLLKHFNSRCCQLVLGAGALQAVGLKTITTRNLALASRCLQLVVHYIPVIRAHF 849

  Fly   800 QA---------MSGYETIERDYQGHIKEIENKIHGIVSERLAAQLDAWEARPPIPSQTFRHISRH 855
            :.         :..::.|.:||..||.|:..|:..|:.......:..:|.:.|:||...|::.:.
Zfish   850 ETRLQPKQYSILRHFDHITKDYNDHIAEVSAKLVAIMDSMFEKAVSKYEVKAPMPSACLRNVCKQ 914

  Fly   856 LVKLHEAIAGVLPEAQIHEIYGVVHRNFKDKLREQLLKLNVNNNGGPQHGVVTSELTFYMETLRT 920
            ::|:||||..:|||.|...::..::.:||..|:.||.:|.|:|:||||:|:|..::.||.|.::.
Zfish   915 MLKMHEAIHELLPEEQTQMLFLRINASFKLHLKRQLSRLGVSNDGGPQNGLVMVDVAFYSENVQG 979

  Fly   921 LKALPAEQLDNGILEEIW 938
            |::|  |:||.. :.|||
Zfish   980 LRSL--ERLDLN-MPEIW 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scat	NP_524905.1	Vps54	708..830	CDD:285206	52/130 (40%)
scat	NP_524905.1	DUF4164	<810..867	CDD:290465	17/56 (30%)
vps54	NP_001124248.1	Dor1	216..>340	CDD:302817	60/123 (49%)
vps54	NP_001124248.1	Vps54	758..889	CDD:285206	52/130 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583243
Domainoid	1	1.000	151	1.000	Domainoid score	I4334
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5605
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1220
OMA	1	1.010	-	-		QHG55106
OrthoDB	1	1.010	-	-		D454911at33208
OrthoFinder	1	1.000	-	-		FOG0005108
OrthoInspector	1	1.000	-	-		oto41244
orthoMCL	1	0.900	-	-		OOG6_102785
Panther	1	1.100	-	-	LDO	PTHR12965
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910