DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scat and VPS54

DIOPT Version :9

Sequence 1:	NP_524905.1	Gene:	scat / 47942	FlyBaseID:	FBgn0011232	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_057600.2	Gene:	VPS54 / 51542	HGNCID:	18652	Length:	977	Species:	Homo sapiens

Alignment Length:	971	Identity:	338/971 - (34%)
Similarity:	501/971 - (51%)	Gaps:	154/971 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 VCASLPLDGVSDRDYDAHVAKYHV-NQHTREMPPEWGVYSAAQNLPAVLNDPSRGK-QSNLFTKK 148
            ||   |.:...| .:..:||...| :||      .|.||.:..||||.||||...| :|:.|||.
Human    39 VC---PKEPTGD-SHSLYVAPSLVTDQH------RWTVYHSKVNLPAALNDPRLAKRESDFFTKT 93

  Fly   149 WGEHFVERSHVPPSPRLPDITHADFTVYLGSIGKRYRWHERRQQQLERDKPLENGAQGAPGPGTG 213
            ||..||: :.|.||..||.|:...||||...|.:|.:.|||.:.........|....     .|.
Human    94 WGLDFVD-TEVIPSFYLPQISKEHFTVYQQEISQREKIHERCKNICPPKDTFERTLL-----HTH 152

  Fly   214 GQTPTHLSSVPEIFLKSQLQLHHPATFKQVFP-NYMQTSASSPESHQQTGRQLQEQLSHYLDMVE 277
            .::.|.|..||:||:|....|....||..|.| ::..|:.........:.:.|||:||||||:||
Human   153 DKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGNRDAASSKLLQEKLSHYLDIVE 217

  Fly   278 VKIAQQVSQKSAAFFHAMTTQHAILAEMEQAADQVRQLRAALAELHSHSVVDSFKVLRFAQRRQH 342
            |.||.|:|.:|.|||||||:||.:...:.:.:..|:.||..:|::.......|..:||.|..|.:
Human   218 VNIAHQISLRSEAFFHAMTSQHELQDYLRKTSQAVKMLRDKIAQIDKVMCEGSLHILRLALTRNN 282

  Fly   343 YNLTLDKLRLMATVHKTQPMLQLLLGTQDYVAALDLIGTTQEILSAELLGIHCFKHLPMQLSEME 407
            .....:||:||||||:|||.:|:||.|.::|.|||||.||||:|..||.|||.|:||..||.|:|
Human   283 CVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGIHSFRHLGSQLCELE 347

  Fly   408 KLIDKMLTTEFERYAAADLNRPLTDALRETDSVCAEEDKLVAIVMGLLRKQNFSFVQAYQQEAIA 472
            ||||||:..||..|:.:||||||.|     |....||::|:::|.|||:::..:|::.|.::.:.
Human   348 KLIDKMMIAEFSTYSHSDLNRPLED-----DCQVLEEERLISLVFGLLKQRKLNFLEIYGEKMVI 407

  Fly   473 TIRAIIKQLLIEVLARS---DSDQEISLTGHGEQALELTLPEWIALLQRSSQALVSILERIKTVV 534
            |.:.||||.:|..::::   |:|..:.|   .:|...|..|:|..||:.........|:|:|..:
Human   408 TAKNIIKQCVINKVSQTEEIDTDVVVKL---ADQMRMLNFPQWFDLLKDIFSKFTIFLQRVKATL 469

  Fly   535 GI-----------------MQQTADAAVGAQDAVNLIDSEA--------FLSPGHHE-------- 566
            .|                 :::.:.....|:|  |.:|:|.        |:|....|
Human   470 NIIHSVVLSVLDKNQRTRELEEISQQKNAAKD--NSLDTEVAYLIHEGMFISDAFGEGELTPIAV 532

  Fly   567 -------------------------------------------------------------QLKN 570
                                                                         :|.|
Human   533 DTTSQRNASPNSEPCSSDSVSEPECTTDSSSSKEHTSSSAIPGGVDIMVSEDMKLTDSELGKLAN 597

  Fly   571 QLQQLLQAVCHYCHERCANIVSPQS----LERSSASEQELFQLSEIVDHFGETTRSICGVASVPL 631
            .:|:||.:....||:|....:..::    ||:  .:..|...||.:::.|...|..|||..|..|
Human   598 NIQELLYSASDICHDRAVKFLMSRAKDGFLEK--LNSMEFITLSRLMETFILDTEQICGRKSTSL 660

  Fly   632 QLALKVQASRYAQRFHSERKQKLSLLLDQERWRQVDIPHEFQRIIERMAAGDYAKPEMGNLISNG 696
            ..||:.||.::..|||.|||.|||||||.|||:|.|:|.|||.:::.::.|..|.||.    .:|
Human   661 LGALQSQAIKFVNRFHEERKTKLSLLLDNERWKQADVPAEFQDLVDSLSDGKIALPEK----KSG 721

  Fly   697 AGN-----PVLLVEGKQPYTLVSASLMLIRMLYEYGCSAHRLPLLASYHARNVVDLLRCFNSRSC 756
            |..     .||:|||:| |.:|...|:|||::.||......:|.:.:.....:.|||:.||||||
Human   722 ATEERKPAEVLIVEGQQ-YAVVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLSDLLKYFNSRSC 785

  Fly   757 QLIIGAGAMRVAGLKTITSTNLALVSRALQLVLWLLPKLKEHFQA---------MSGYETIERDY 812
            ||::||||::|.||||||:.||||.||.|||::..:|.::.||:|         :..::.|.:||
Human   786 QLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPPKQYSMLRHFDHITKDY 850

  Fly   813 QGHIKEIENKIHGIVSERLAAQLDAWEARPPIPSQTFRHISRHLVKLHEAIAGVLPEAQIHEIYG 877
            ..||.||..|:..|:.......|..:|.:.|:||..||:|.:.:.|:||||..:|||.|...::.
Human   851 HDHIAEISAKLVAIMDSLFDKLLSKYEVKAPVPSACFRNICKQMTKMHEAIFDLLPEEQTQMLFL 915

  Fly   878 VVHRNFKDKLREQLLKLNVNNNGGPQHGVVTSELTFYMETLRTLKALPAEQLDNGILEEIW 938
            .::.::|..|::||..|||.|:||||:|:||:::.||...|:.||.|....|:   :.|||
Human   916 RINASYKLHLKKQLSHLNVINDGGPQNGLVTADVAFYTGNLQALKGLKDLDLN---MAEIW 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scat	NP_524905.1	Vps54	708..830	CDD:285206	54/130 (42%)
scat	NP_524905.1	DUF4164	<810..867	CDD:290465	21/56 (38%)
VPS54	NP_057600.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..575		0/39 (0%)
VPS54	NP_057600.2	Vps54	737..867	CDD:285206	54/130 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149188
Domainoid	1	1.000	161	1.000	Domainoid score	I4034
eggNOG	1	0.900	-	-		E1_KOG2115
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5605
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1139
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55106
OrthoDB	1	1.010	-	-		D449680at2759
OrthoFinder	1	1.000	-	-		FOG0005108
OrthoInspector	1	1.000	-	-		oto89074
orthoMCL	1	0.900	-	-		OOG6_102785
Panther	1	1.100	-	-	LDO	PTHR12965
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1658
SonicParanoid	1	1.000	-	-		X4728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800