Protein Alignment scat and VPS54

DIOPT Version :10

• Sequence 1: NP_524905.1
• Gene: scat / 47942
• FlyBaseID: FBgn0011232
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_057600.2
• Gene: VPS54 / 51542
• HGNCID: 18652
• Length: 977
• Species: Homo sapiens
• Alignment Length: 971
• Identity: 338/971 - (34%)
• Similarity: 501/971 - (51%)
• Gaps: 154/971 - (15%)

  Fly    86 VCASLPLDGVSDRDYDAHVAKYHV-NQHTREMPPEWGVYSAAQNLPAVLNDPSRGK-QSNLFTKK 148
            ||   |.:...| .:..:||...| :||      .|.||.:..||||.||||...| :|:.|||.
Human    39 VC---PKEPTGD-SHSLYVAPSLVTDQH------RWTVYHSKVNLPAALNDPRLAKRESDFFTKT 93

  Fly   149 WGEHFVERSHVPPSPRLPDITHADFTVYLGSIGKRYRWHERRQQQLERDKPLENGAQGAPGPGTG 213
            ||..||: :.|.||..||.|:...||||...|.:|.:.|||.:.........|....     .|.
Human    94 WGLDFVD-TEVIPSFYLPQISKEHFTVYQQEISQREKIHERCKNICPPKDTFERTLL-----HTH 152

  Fly   214 GQTPTHLSSVPEIFLKSQLQLHHPATFKQVFP-NYMQTSASSPESHQQTGRQLQEQLSHYLDMVE 277
            .::.|.|..||:||:|....|....||..|.| ::..|:.........:.:.|||:||||||:||
Human   153 DKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGNRDAASSKLLQEKLSHYLDIVE 217

  Fly   278 VKIAQQVSQKSAAFFHAMTTQHAILAEMEQAADQVRQLRAALAELHSHSVVDSFKVLRFAQRRQH 342
            |.||.|:|.:|.|||||||:||.:...:.:.:..|:.||..:|::.......|..:||.|..|.:
Human   218 VNIAHQISLRSEAFFHAMTSQHELQDYLRKTSQAVKMLRDKIAQIDKVMCEGSLHILRLALTRNN 282

  Fly   343 YNLTLDKLRLMATVHKTQPMLQLLLGTQDYVAALDLIGTTQEILSAELLGIHCFKHLPMQLSEME 407
            .....:||:||||||:|||.:|:||.|.::|.|||||.||||:|..||.|||.|:||..||.|:|
Human   283 CVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGIHSFRHLGSQLCELE 347

  Fly   408 KLIDKMLTTEFERYAAADLNRPLTDALRETDSVCAEEDKLVAIVMGLLRKQNFSFVQAYQQEAIA 472
            ||||||:..||..|:.:||||||.|     |....||::|:::|.|||:::..:|::.|.::.:.
Human   348 KLIDKMMIAEFSTYSHSDLNRPLED-----DCQVLEEERLISLVFGLLKQRKLNFLEIYGEKMVI 407

  Fly   473 TIRAIIKQLLIEVLARS---DSDQEISLTGHGEQALELTLPEWIALLQRSSQALVSILERIKTVV 534
            |.:.||||.:|..::::   |:|..:.|   .:|...|..|:|..||:.........|:|:|..:
Human   408 TAKNIIKQCVINKVSQTEEIDTDVVVKL---ADQMRMLNFPQWFDLLKDIFSKFTIFLQRVKATL 469

  Fly   535 GI-----------------MQQTADAAVGAQDAVNLIDSEA--------FLSPGHHE-------- 566
            .|                 :::.:.....|:|  |.:|:|.        |:|....|
Human   470 NIIHSVVLSVLDKNQRTRELEEISQQKNAAKD--NSLDTEVAYLIHEGMFISDAFGEGELTPIAV 532

  Fly   567 -------------------------------------------------------------QLKN 570
                                                                         :|.|
Human   533 DTTSQRNASPNSEPCSSDSVSEPECTTDSSSSKEHTSSSAIPGGVDIMVSEDMKLTDSELGKLAN 597

  Fly   571 QLQQLLQAVCHYCHERCANIVSPQS----LERSSASEQELFQLSEIVDHFGETTRSICGVASVPL 631
            .:|:||.:....||:|....:..::    ||:  .:..|...||.:::.|...|..|||..|..|
Human   598 NIQELLYSASDICHDRAVKFLMSRAKDGFLEK--LNSMEFITLSRLMETFILDTEQICGRKSTSL 660

  Fly   632 QLALKVQASRYAQRFHSERKQKLSLLLDQERWRQVDIPHEFQRIIERMAAGDYAKPEMGNLISNG 696
            ..||:.||.::..|||.|||.|||||||.|||:|.|:|.|||.:::.::.|..|.||.    .:|
Human   661 LGALQSQAIKFVNRFHEERKTKLSLLLDNERWKQADVPAEFQDLVDSLSDGKIALPEK----KSG 721

  Fly   697 AGN-----PVLLVEGKQPYTLVSASLMLIRMLYEYGCSAHRLPLLASYHARNVVDLLRCFNSRSC 756
            |..     .||:|||:| |.:|...|:|||::.||......:|.:.:.....:.|||:.||||||
Human   722 ATEERKPAEVLIVEGQQ-YAVVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLSDLLKYFNSRSC 785

  Fly   757 QLIIGAGAMRVAGLKTITSTNLALVSRALQLVLWLLPKLKEHFQA---------MSGYETIERDY 812
            ||::||||::|.||||||:.||||.||.|||::..:|.::.||:|         :..::.|.:||
Human   786 QLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPPKQYSMLRHFDHITKDY 850

  Fly   813 QGHIKEIENKIHGIVSERLAAQLDAWEARPPIPSQTFRHISRHLVKLHEAIAGVLPEAQIHEIYG 877
            ..||.||..|:..|:.......|..:|.:.|:||..||:|.:.:.|:||||..:|||.|...::.
Human   851 HDHIAEISAKLVAIMDSLFDKLLSKYEVKAPVPSACFRNICKQMTKMHEAIFDLLPEEQTQMLFL 915

  Fly   878 VVHRNFKDKLREQLLKLNVNNNGGPQHGVVTSELTFYMETLRTLKALPAEQLDNGILEEIW 938
            .::.::|..|::||..|||.|:||||:|:||:::.||...|:.||.|....|:   :.|||
Human   916 RINASYKLHLKKQLSHLNVINDGGPQNGLVTADVAFYTGNLQALKGLKDLDLN---MAEIW 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scat	NP_524905.1	COG2	268..>418	CDD:473160	76/149 (51%)
		Vps54	708..829	CDD:462318	54/129 (42%)
		DUF4164	<810..867	CDD:433450	21/56 (38%)
VPS54	NP_057600.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..575		0/39 (0%)
		Vps54	737..865	CDD:462318	53/128 (41%)