DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scat and vps54

DIOPT Version :9

Sequence 1:	NP_524905.1	Gene:	scat / 47942	FlyBaseID:	FBgn0011232	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_594389.1	Gene:	vps54 / 2541725	PomBaseID:	SPAC2F3.10	Length:	949	Species:	Schizosaccharomyces pombe

Alignment Length:	957	Identity:	195/957 - (20%)
Similarity:	355/957 - (37%)	Gaps:	250/957 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 RSHVPP---SPRLPDITHADFTVYLGSIGKRYRWHERR-----QQQLERDKPLE--------NG- 203
            |:.:.|   || :|.....:|..||..|.:.|..:.::     ::.||:...||        ||
pombe    56 RTEITPVTLSP-IPITPVREFQPYLHEISQEYARYSKQKRASLRRYLEKHGKLEGSMKESSINGS 119

  Fly   204 -------------AQGAPGPGTGGQTPTH-----------------LSSVPEIFLKSQLQLHHPA 238
                         |..:..|.:..:|.|:                 :||||.:|.:|...|..|.
pombe   120 LLRRSSVSTILRPASESSYPNSNSETITYDIDDNVNPSSSLVDNFSISSVPSVFFQSDFNLDDPQ 184

  Fly   239 TFKQVFPNYMQTSAS-SPESHQQ---TGRQLQEQLSHYLDMVEVKIAQQVSQKSAAFFHAMTTQH 299
            .|..|..:...|..| :|.|::.   ....|||::|.|||.||:.:.|::...|.:|...:....
pombe   185 IFDVVSEHIDITQTSDAPNSNRNLLLNNSMLQEKISWYLDTVELHLLQEIENASDSFPMIIDNLK 249

  Fly   300 AILAEMEQAADQVRQLRAALA----------------ELHSHSVVDSFKVLRFAQ--RRQHYNLT 346
            .:..|.....::.:.|...|.                ||..|.:....||::..:  ..:|..::
pombe   250 QLKKETRDNVEETKHLLEKLTEVNVMCDRHMDAISSEELACHQLTQLKKVVQTLEDIYSEHKKVS 314

  Fly   347 LDKLRLMATVHKTQPMLQLLLGTQDYVAALDLIGTTQEILSAELLGIHCFKHLPMQLSEMEKLID 411
            .|.        |.|..|:.:.|....|..|....|.   |:.:||.:...|.|..:...:...:.
pombe   315 EDV--------KDQRFLEAINGINSIVTQLKKKSTE---LNVDLLSLPSVKSLREEHKVLYHTVS 368

  Fly   412 KMLTTEFERYAAADLNRPLT---------------------------------DALRETDSVCAE 443
            :.:..:|.::..:|:::..|                                 |.|.|.| ||.:
pombe   369 QSVVQQFSKFLTSDMHKFSTILDSNELKDIYLSKNRLIPSVTKSLPSAMEFDADFLHEVD-VCID 432

  Fly   444 ----EDKLVAIVMGLLRKQNF----SFVQAYQQEAIATIRAIIKQ-------LLIEVLARSDSDQ 493
                .|.|.| .:.|.:...|    :..|.|..:.: .:|::.|.       ....:.:.|||.:
pombe   433 CLTLTDSLQA-ALTLYKTAVFEAFENLAQQYFTDGV-EMRSVRKSSDLRRSLSAASLSSLSDSSR 495

  Fly   494 EISLTGHGEQALELTLPEWIALLQR----SSQALVSILERIKTVVGIMQQTADAAVGAQDAVNLI 554
            ..|...:..|::.:|  |:..:|..    |.:.|..|..:||.::.|:.:.
pombe   496 RSSSAANPFQSMSIT--EFAEMLTNIYFSSLECLRRIRSQIKVLIDILSKK-------------- 544

  Fly   555 DSEAFLSPGHHEQLKNQL---------QQLLQAVCHYCHERCANIVSPQSLERSSASEQELFQLS 610
            |::.:    |...:.|.|         ||:  ...:....|..:...|.::       ..||.|.
pombe   545 DTKQY----HLSVILNDLMATSSDVVTQQV--TTINNLRFRVLDTYPPNNV-------IYLFSLH 596

  Fly   611 EIVDHFGETTRSICGVASVPLQLALKVQASRYAQRFHSERKQKLSLLLDQERWRQVDIPHEFQRI 675
            .|   |.....|:||:........:..|...:.:.|.....|||:...::|.|..:.:....|.:
pombe   597 II---FHNELESLCGITQSSFIPTIMRQLLDWFKNFQRYSTQKLASSFERELWEAIPVEPSCQDL 658

  Fly   676 IERM--AAGD-------YAKPEMGNLISNGAGNPVLLVE--------GKQPYTLVSASLMLIRML 723
            ..|:  .:|:       ...||......|...:.|.:.|        |||...:|.:|:.|:..|
pombe   659 ANRVFECSGNTPVEWTRLLSPEAEKEDENHRVHHVKVSEDCTATVSFGKQSLHIVRSSVTLLETL 723

  Fly   724 YEYGCSAHRLPLLASYHARNVVDLLRCFNSRSCQLIIGAGAMRVAGLKTITSTNLALVSRALQLV 788
            .:||........||......::|:.|..|||..|||:|||.:|.:||..:...::||.|:.:.|.
pombe   724 DDYGKLLAHFSRLAPEFQTGMLDMFRTLNSRVYQLILGAGTVRSSGLSKVLGKHIALASQTIALF 788

  Fly   789 LWLLPKLKEHFQAMSG----YET--IERDYQGHIKEIENKIHGIVSERLAAQLD-----AWEARP 842
            ...|..:..:...::|    .||  :::|:..|..:|.:|...::.||:|....     :|:...
pombe   789 QLSLNSMCRYLSRVTGTRLTNETNKLDQDFTVHHLQIHDKFVSLMRERVAISCSQIASLSWDIDS 853

  Fly   843 PIPSQTFRH-----ISRHLVKLHEAI--------AGVLPEAQIHEIYGVVHRNFKDKLREQLLKL 894
            |       |     :|:.|:||::.:        ..|:|:         |.|.|:|:|:.:|..:
pombe   854 P-------HGYIIDLSKSLIKLYKVLHRYSQRDCVEVIPD---------VIRMFEDRLQLELTDI 902

  Fly   895 NVNNNGGPQHGVVTSELTFYMETL---------RTL----KALPAEQ 928
            ..|.:..|.   |..:|:::.:.:         |||    :..|.:|
pombe   903 ARNPSKWPG---VRIDLSYFYDMMASKCGYAGDRTLLEKFERTPEQQ 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scat	NP_524905.1	Vps54	708..830	CDD:285206	35/127 (28%)
scat	NP_524905.1	DUF4164	<810..867	CDD:290465	14/74 (19%)
vps54	NP_594389.1	Vps54	708..836	CDD:285206	35/127 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	56	1.000	Domainoid score	I3166
eggNOG	1	0.900	-	-		E1_KOG2115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1450
OMA	1	1.010	-	-		QHG55106
OrthoFinder	1	1.000	-	-		FOG0005108
OrthoInspector	1	1.000	-	-		oto100805
orthoMCL	1	0.900	-	-		OOG6_102785
Panther	1	1.100	-	-	LDO	PTHR12965
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1658
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900