DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dek and DEK

DIOPT Version :9

Sequence 1:	NP_652058.1	Gene:	Dek / 47906	FlyBaseID:	FBgn0026533	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_016866762.1	Gene:	DEK / 7913	HGNCID:	2768	Length:	380	Species:	Homo sapiens

Alignment Length:	532	Identity:	151/532 - (28%)
Similarity:	217/532 - (40%)	Gaps:	194/532 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 ATDESKPKSGAD--KPKKPEPKAKNGKVAKEEDDDEEDEDDEDAEDDDGDEN---DGLDKNNEVA 218
            |..|..|...|.  :|:.|.|        :||.::|||||||:.|:::.:::   :|..:..:|.
Human     8 AEGEGTPTQPASEKEPEMPGP--------REESEEEEDEDDEEEEEEEKEKSLIVEGKREKKKVE 64

  Fly   219 EDDENVVA---------------LAEIDRINENINKTRVDGLQTLHAICFGAQGKNNVVKKNLRS 268
            .....|.:               |.||:||:..::|.:.|.|:.||.:.:...|..:.:|||:..
Human    65 RLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQ 129

  Fly   269 FAGFEFAKDSAEYNKKLEAIKKVDNKGLRSICEILTLDRKGSKNETVLRVLKFLMEPDESLCLEQ 333
            |:||.|.|.|.:|.||.|.:||..|..|:||||:|.|:|.|..:|.|.|:|.|||.|..|
Human   130 FSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPS----- 189

  Fly   334 GDEEEEEDAEDEDLDEDEEDPPSEEDKKRKSGKSSGGAGRGSARNSTGRPRRATAGKKMSAYVDF 398
                               ..|..:.||..|      .|....|||:|..|:|...|......|.
Human   190 -------------------GKPLPKSKKTCS------KGSKKERNSSGMARKAKRTKCPEILSDE 229

  Fly   399 SSSDDSEQKVAVPKRRRNDDSESGSDYNPSANSDSDGGRGGGAGAAGRKVPSRGGRGRPARKSRR 463
            ||||:.|:|
Human   230 SSSDEDEKK-------------------------------------------------------- 238

  Fly   464 RNSDSEEEEESEVSDADSDVPKRKRGSVGKRGRPAAPASAGRRGRGRGAASRKRKDSDSEDEEVS 528
                                                               .|.:.||.||:|
Human   239 ---------------------------------------------------NKEESSDDEDKE-- 250

  Fly   529 EDEEEEDVSDFASDQSEEERPKKSKKPITPAKNSKANNKSKPA------GKADSRSKKSKKESSE 587
                           ||||.|||:.|...|  ..||.:|||.:      .||||.:.|..:.||:
Human   251 ---------------SEEEPPKKTAKREKP--KQKATSKSKKSVKSANVKKADSSTTKKNQNSSK 298

  Fly   588 EDDDVDDKDESDEDEPLTKKGKQAFPTDEQIRGYVKEILDKANLEEITMKTVCKQVYAKYPDFDL 652
            ::.:.:|   |.:||||.||.|:. ||||:::..:|::|..|||||:|||.:||:||..||.:||
Human   299 KESESED---SSDDEPLIKKLKKP-PTDEELKETIKKLLASANLEEVTMKQICKKVYENYPTYDL 359

  Fly   653 TDKKDFIKATVK 664
            |::|||||.|||
Human   360 TERKDFIKTTVK 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dek	NP_652058.1	RR_TM4-6	<70..>150	CDD:283990
		SAP	288..322	CDD:128789	16/33 (48%)
		DEK_C	615..667	CDD:285919	29/50 (58%)
DEK	XP_016866762.1	SAP	149..183	CDD:128789	16/33 (48%)
DEK	XP_016866762.1	DEK_C	320..373	CDD:312337	31/52 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141353
Domainoid	1	1.000	124	1.000	Domainoid score	I5567
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1505933at2759
OrthoFinder	1	1.000	-	-		FOG0004773
OrthoInspector	1	1.000	-	-		oto88828
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13468
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3357
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.950