DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dek and dek

DIOPT Version :9

Sequence 1:	NP_652058.1	Gene:	Dek / 47906	FlyBaseID:	FBgn0026533	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_005158284.1	Gene:	dek / 692304	ZFINID:	ZDB-GENE-060512-191	Length:	447	Species:	Danio rerio

Alignment Length:	576	Identity:	167/576 - (28%)
Similarity:	247/576 - (42%)	Gaps:	175/576 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PEDEADEKASDEESEK--KKPKLDA-EDKIKDATDESKPKSGADKPKKPEPKAK---NGKVAKEE 188
            |.|:|::..|:|.|.|  .|||:.. |.:|.:...|.|.....|...||:.|.|   .|:
Zfish    10 PLDDAEQDESEESSPKTTSKPKVKMFELEIVEGKREKKVIQRLDMMSKPKEKPKIESKGR----- 69

  Fly   189 DDDEEDEDDEDAEDDDGDENDGLDKNNEVAEDDENVVALAEIDRINENINKTRVDGLQTLHAICF 253
                            ||:                   |.:|.|||.:|.|.:...|:.||.|.:
Zfish    70 ----------------GDK-------------------LGDIARINHSIGKLKAPLLKPLHKILY 99

  Fly   254 GAQGKNNVVKKNLRSFAGFEFAKDSAEYNKKLEAIKKVDNKGLRSICEILTLDRKGSKNETVLRV 318
            ...|..:.::||||.|.||.|.:||..||||:|.:|::..|.|::||:.|.|:|.|::.....|:
Zfish   100 DRPGAASTLRKNLRLFNGFPFKEDSDLYNKKMEKVKRLPKKLLKTICQTLDLERSGTQIVLSERI 164

  Fly   319 LKFLMEPDES---------LCLEQGDEEEEE--------------------DAEDEDLDEDEEDP 354
            :|||.:|..|         ...:.|.:|:..                    |:..:|.|:||:|.
Zfish   165 MKFLAQPTNSGKPVLKKKRKTTKDGKKEKSSSKSKKPHKKVVSGKSKPIVTDSSSDDDDDDEDDD 229

  Fly   355 PSEEDKKRKSGKSSGGAGRGSARNSTGRPRRATAGKKMSAYVDFSSSDDSEQKVAVPKRRRNDDS 419
            ..||:.|.|               |.|..:.|.|.:|         .||||.|..:     .::.
Zfish   230 DGEEETKGK---------------SKGTEKSAKASQK---------HDDSEDKSDI-----EEED 265

  Fly   420 ESGSDYNPSANSDSDGGRGGGAGAAGRKVPSRGGRGRPARKSRRRNSDSEEEEESEVSDADSDVP 484
            ||..|.:...|.|                                  ||:|:.:.|.|      |
Zfish   266 ESSDDDDDDDNDD----------------------------------DSKEDSKEETS------P 290

  Fly   485 KRKRGSVGKRGRPAAPASAGRRGRGRGAASRKRKDSDSEDEEVSEDEEEEDVSDFASDQSEEERP 549
            .:|:.|.||                      ..|.||.:.::...||..:|...:..|:.    .
Zfish   291 PQKKSSTGK----------------------STKKSDKKSDQSPSDETTDDSDTYCEDKD----A 329

  Fly   550 KKSKKPITPAKNSKANNKSKP-AGKADSRSKKSKKESSEEDD-DVDDKDESDEDEPLTKKGKQAF 612
            ||:||  .||...||..|..| ..||||.|.:.||.:|:... .:|:.:.||:|:||.|..|:.
Zfish   330 KKTKK--KPAAKRKAPAKPVPKTKKADSSSNRKKKTASKRKVLLLDESESSDDDQPLIKMIKKP- 391

  Fly   613 PTDEQIRGYVKEILDKANLEEITMKTVCKQVYAKYPDFDLTDKKDFIKATVKALIA 668
            |||||::..||::|..|||||:|||.:.:|||.|||||||:.:|:||:.|||.:|:
Zfish   392 PTDEQLKENVKDLLKDANLEEVTMKQITRQVYDKYPDFDLSSRKEFIRETVKNMIS 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dek	NP_652058.1	RR_TM4-6	<70..>150	CDD:283990	9/21 (43%)
		SAP	288..322	CDD:128789	11/33 (33%)
		DEK_C	615..667	CDD:285919	30/51 (59%)
dek	XP_005158284.1	DEK_C	394..446	CDD:285919	30/51 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574258
Domainoid	1	1.000	130	1.000	Domainoid score	I5181
eggNOG	1	0.900	-	-		E1_KOG2266
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1505933at2759
OrthoFinder	1	1.000	-	-		FOG0004773
OrthoInspector	1	1.000	-	-		oto41778
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13468
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4889
SonicParanoid	1	1.000	-	-		X3357
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.980