DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dek and Dek

DIOPT Version :9

Sequence 1:	NP_652058.1	Gene:	Dek / 47906	FlyBaseID:	FBgn0026533	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_080176.2	Gene:	Dek / 110052	MGIID:	1926209	Length:	380	Species:	Mus musculus

Alignment Length:	531	Identity:	152/531 - (28%)
Similarity:	219/531 - (41%)	Gaps:	180/531 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 DATDESKPKSGADKPKKPEPKAKNGKVAKEEDDDEEDEDDEDAEDDDGDENDGLDKNNEVAEDDE 222
            :..|...|.|...:|:.|.|:.::.:  :||||:::||:||:.|.:.....:|..:..:|.....
Mouse    10 EGEDAPVPPSSEKEPEMPGPREESEE--EEEDDEDDDEEDEEEEKEKSLIVEGKREKKKVERLTM 72

  Fly   223 NVVA---------------LAEIDRINENINKTRVDGLQTLHAICFGAQGKNNVVKKNLRSFAGF 272
            .|.:               |.||:||:..::|.:.|.|:.||.:.:...|..:.:|||:..|:||
Mouse    73 QVSSLQREPFTVTQGKGQKLCEIERIHFFLSKKKPDELRNLHKLLYNRPGTVSSLKKNVGQFSGF 137

  Fly   273 EFAKDSAEYNKKLEAIKKVDNKGLRSICEILTLDRKGSKNETVLRVLKFLMEPDESLCLEQGDEE 337
            .|.|.|.:|.||.|.:||..|..|:||||:|.|:|.|..:|.|.|:|.|||.|..|
Mouse   138 PFEKGSTQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPS--------- 193

  Fly   338 EEEDAEDEDLDEDEEDPPSEEDKKRKSGKSSGGAGRGSARNSTGRPRRATAGKKMSAYVDFSSSD 402
                                 .|.....|.|...|....|||:|..|::...|......|.||||
Mouse   194 ---------------------GKPLPKSKKSSSKGSKKERNSSGTTRKSKQTKCPEILSDESSSD 237

  Fly   403 DSEQKVAVPKRRRNDDSESGSDYNPSANSDSDGGRGGGAGAAGRKVPSRGGRGRPARKSRRRNSD 467
            :.|:|
Mouse   238 EDEKK------------------------------------------------------------ 242

  Fly   468 SEEEEESEVSDADSDVPKRKRGSVGKRGRPAAPASAGRRGRGRGAASRKRKDSDSEDEEVSEDEE 532
                                                                   ..||.|||||
Mouse   243 -------------------------------------------------------NKEESSEDEE 252

  Fly   533 EEDVSDFASDQSEEERP--KKSKKPITPAK---NSKANNKSKPAGKADSRSKKSKKESSEEDDDV 592
            :|         ||||:|  |.|||.....|   .||.:.||....||||.:.|..::||:::.:.
Mouse   253 KE---------SEEEQPPKKTSKKEKAKQKATAKSKKSVKSANVKKADSSTTKKNQKSSKKESES 308

  Fly   593 DDKDESDEDEPLTKKGKQAFPTDEQIRGYVKEILDKANLEEITMKTVCKQVYAKYPDFDLTDKKD 657
            :|   |.:||||.||.|:. ||||:::..||::|..|||||:|||.:||:||..||.:|||::||
Mouse   309 ED---SSDDEPLIKKLKKP-PTDEELKETVKKLLADANLEEVTMKQICKEVYENYPAYDLTERKD 369

  Fly   658 FIKATVKALIA 668
            |||.|||.||:
Mouse   370 FIKTTVKELIS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dek	NP_652058.1	RR_TM4-6	<70..>150	CDD:283990
		SAP	288..322	CDD:128789	16/33 (48%)
		DEK_C	615..667	CDD:285919	30/51 (59%)
Dek	NP_080176.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		16/56 (29%)
		SAP	153..187	CDD:128789	14/33 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..330		17/141 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	209..225		3/15 (20%)
		DEK_C	325..379	CDD:400903	1/53 (2%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831294
Domainoid	1	1.000	76	1.000	Domainoid score	I9002
eggNOG	1	0.900	-	-		E1_KOG2266
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004773
OrthoInspector	1	1.000	-	-		oto92393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13468
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4889
SonicParanoid	1	1.000	-	-		X3357
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830