DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and ABCC12

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001380726.1 Gene:ABCC12 / 94160 HGNCID:14640 Length:1359 Species:Homo sapiens


Alignment Length:1366 Identity:427/1366 - (31%)
Similarity:709/1366 - (51%) Gaps:165/1366 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEE-QKSDILGNRLCASWERELKND 149
            |..||...:..:|...|.:..|:..||||:.| :.|...||.. ..||....|....|:.|:...
Human    41 LAPNPVDDAGLLSFATFSWLTPVMVKGYRQRL-TVDTLPPLSTYDSSDTNAKRFRVLWDEEVARV 104

  Fly   150 GRSPSLVRALLRVFGWQLGFPGLAIFVVE----LGLRTLQPIFLV-KLISYFSGEPDAANAGFYY 209
            |..    :|.|....|:.....:.:.:|.    :.:..:.|..|: :::............|...
Human   105 GPE----KASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPTVLIHQILQQTERTSGKVWVGIGL 165

  Fly   210 AVAQIVISALTVMILTPTTFGIHH-VCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISND 273
            .:| :..:..|.:......:.|:: ...:::||:.:::|...:...  .|...:.|.|:|::|:|
Human   166 CIA-LFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSFK--TLTHISVGEVLNILSSD 227

  Fly   274 IPRLDSA------PYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSA 332
            ...|..|      |.|:      |:.::......:..:|.:|:.|:...::|:|:||::....||
Human   228 SYSLFEAALFCPLPATI------PILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSA 286

  Fly   333 IQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRI 397
            .:..|...||.|::.:||.::.|:::||||||:.|...:...|.:|...:.:..:::..:.|...
Human   287 FRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAP 351

  Fly   398 VLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFM 462
            ::|.:||.|:|..:::|.:..|..:||.:.|.:||:..:::| :|.:|...|:...|:||:::.:
Human   352 IVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAI-LPFSIKAMAEANVSLRRMKKIL 415

  Fly   463 QSEELGSSDKSEGPSKDTVPGNPPS------------------------NNNEADLLK----SAI 499
                   .|||. ||..|.|.:|.:                        .|.:..|.|    .|.
Human   416 -------IDKSP-PSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAY 472

  Fly   500 SIRDLKAKW------DPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQL 558
            |.|...||.      ..:|....|..|:..::.|.::.:.|..|||||||:.|:||:::...|.:
Human   473 SERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVV 537

  Fly   559 QVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGAT 623
            .|||:|:|.||::|:|.|.||:|||||:..|.|||:..|:.|.|::|...||..|.|.:||||..
Human   538 AVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLN 602

  Fly   624 LSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPH 688
            |||||:.||||||:||....:||||||||||||.|.:|:|::|::..|||.||||||||.|||..
Human   603 LSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLES 667

  Fly   689 VDQIVILANGQIKALGDYESLLK-----TGLITGLGSLS----------------KTDKAKTEEQ 732
            .|::::|.:|:|...|.::.|::     ..||..|..|.                |...|:.||.
Human   668 CDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREED 732

  Fly   733 EPLNLNSPDNKNEVTPIKENSEQTVGG---SSSGKEH----VERQESGGISLALYRKYFQAGGG- 789
            ..:.:.:|.|:.:     |..|...|.   .:...||    .|..:.|.::...|..|.:|.|| 
Human   733 AGIIVLAPGNEKD-----EGKESETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGY 792

  Fly   790 ------LVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAA----GHGEMEDMESKSMDV---- 840
                  :..||:|:.|:..:       :::|..|:.|.|...    |:..|.::.:...|:    
Human   793 LLSLFTVFLFLLMIGSAAFS-------NWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHV 850

  Fly   841 --YKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKD 903
              :.||..::..::..::..|:.......||..||:|:|:::.::.|.||.....|.::|||:||
Human   851 YQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKD 915

  Fly   904 MSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVE 968
            |.::|..||....:.:|....:..|::::|.|.|.:|:....|:|.|:.|..::.:..::||:||
Human   916 MDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVE 980

  Fly   969 AINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGY-------C 1026
            .::|||.::|:.:|:.||..|.|             |....|...:..:..:.|..:       .
Human   981 NVSRSPWFTHITSSMQGLGIIHA-------------YGKKESCITYHLLYFNCALRWFALRMDVL 1032

  Fly  1027 MNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYE 1091
            ||.:......::||||.:.   :.:..||.::..:.|..::|..||...|.:...|:||.:.||.
Human  1033 MNILTFTVALLVTLSFSSI---STSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYI 1094

  Fly  1092 SIEPEGMLEAPDDKKP------PKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVG 1150
            |      ...|:...|      ||.||.:|||.|::..:||..|...  ||.||:..||..:.||
Human  1095 S------TCVPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPL--VLDSLNLNIQSGQTVG 1151

  Fly  1151 IVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLD 1214
            ||||||:|||||..||||| ....|::.||..|...:.|.|||.::::|||:||||.||:|||||
Human  1152 IVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLD 1216

  Fly  1215 PFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMD 1279
            ||:.::||.||..||...:::.:..||:.|.::::|.|.|||||:|||:|:|||:||.::|:::|
Human  1217 PFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLD 1281

  Fly  1280 EATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSD 1344
            ||||::|.:||.|:|.||:..|:.||||||||||:|:::.|.|:||:.|:|:||..|..|..|.|
Human  1282 EATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPD 1346

  Fly  1345 S 1345
            |
Human  1347 S 1347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 423/1359 (31%)
ABC_membrane 171..437 CDD:294371 59/277 (21%)
ABCC_MRP_domain1 499..699 CDD:213217 98/205 (48%)
ABC_membrane 799..1045 CDD:294371 62/262 (24%)
ABCC_MRP_domain2 1115..1336 CDD:213211 113/221 (51%)
ABCC12NP_001380726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..491 8/44 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151587
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.660

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