DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and ABCC10

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_016866934.1 Gene:ABCC10 / 89845 HGNCID:52 Length:1558 Species:Homo sapiens


Alignment Length:1363 Identity:424/1363 - (31%)
Similarity:689/1363 - (50%) Gaps:144/1363 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 KEKVLPENPRAR-----SNFISSLCFWYTIPIFRKGYRKTL-DSTDLYRPLEEQKSDILGNRLCA 140
            :|.:|||:....     .:::|...:.:..|:..:|....| ...|:.|.....:...|.....|
Human   252 QEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQA 316

  Fly   141 SWE------RELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGE 199
            .|:      |.|........|...||::.|..|||.|              |:.|..|:.:....
Human   317 HWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSG--------------PLLLSLLVGFLEEG 367

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSG 264
            .:..:.|..||:.....:.|..::.....:.::.|..:.|.|:.::::.|||:|....   ..:|
Human   368 QEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTG 429

  Fly   265 HVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTR 329
            ..:||:..|..||.:...:.|..|..|||:.:..||:||::|::.|.|::..||.:|:...:.||
Human   430 EALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATR 494

  Fly   330 TSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRG---F 391
            ..|...:..:..|.|:::|.|::|.|:|:|...|||.....|...|.:|:..:|..:|:..   :
Human   495 IMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVY 559

  Fly   392 DFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIR 456
            .:|...|:..:.||::   ||::|...|....|...|...:|:..::.: |..|....:...|:.
Human   560 LWAALPVVISIVIFIT---YVLMGHQLTATKVFTALALVRMLILPLNNF-PWVINGLLEAKVSLD 620

  Fly   457 RVEQFMQ----------SEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPN 511
            |::.|:.          |.:.|   :.....|..:..:||:..:      :.:.:......|||.
Human   621 RIQLFLDLPNHNPQAYYSPDCG---RLGAQIKWLLCSDPPAEPS------TVLELHGALFSWDPV 676

  Fly   512 SPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNG---SLSYTSQESWL 573
            .........:||:|.|.:|.::|..|.|||||:.||.|||....|.:.|.|   .....:||.|:
Human   677 GTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWI 741

  Fly   574 FSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSV 638
            ...|:|.|||||:..|:|.|:||::.|||..|..:||..|.|.|||:|.||||||:|||:|||:|
Human   742 QFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAV 806

  Fly   639 YRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKAL 703
            |::..:|||||||:||||.||.||..:|:.|.|..:|.:|.||:.::|...|.::::..|::...
Human   807 YQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRA 871

  Fly   704 GDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGG-----SSSG 763
            |....:|..        :....||..|       |..::.:......:|.|:|..|     |:||
Human   872 GPPSEILPL--------VQAVPKAWAE-------NGQESDSATAQSVQNPEKTKEGLEEEQSTSG 921

  Fly   764 K-EHVERQESGGISLALYRKYFQA-GGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAG 826
            : ...|.::.|.::|.:|:.|::| |.||.  |.:|.|.:|.|......|::|::|:.:......
Human   922 RLLQEESKKEGAVALHVYQAYWKAVGQGLA--LAILFSLLLMQATRNAADWWLSHWISQLKAENS 984

  Fly   827 HGEMEDMES-KSMDVYKYTLII-----------------------------ILSVIMNLSSSFLL 861
            ..|.:...| .||.::...|::                             :.:.|..::|...|
Human   985 SQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTL 1049

  Fly   862 FNI------AKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQ 920
            ...      ..:|:..||..:.:||..|.:.||:....|.|||||:.|::..|:.||.:|..::.
Human  1050 LRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLA 1114

  Fly   921 IALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNG 985
            .|..|.|::.|:.:..|.||:....||:::||::..|..:||:|:|:.::..||:|||||.:|.|
Human  1115 NAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAG 1179

  Fly   986 LTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIIT-LSFFAFPPG- 1048
            |:.:||..|....|:|.....:.:....|...:|.|.....:..:....:|.|. ::......| 
Human  1180 LSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGL 1244

  Fly  1049 -NGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYE---SIEPEGMLEAPDDKKPPK 1109
             |...|||.::.|:.|..::...|....:.|..:.:|||:.||.   ..||:|        :|.:
Human  1245 ANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG--------QPLQ 1301

  Fly  1110 T---WPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LS 1170
            .   |..||.:.|:::.|.|.|.  ..|.|..::|.:||.||:|||||||:|||||:..||| |.
Human  1302 LGTGWLTQGGVEFQDVVLAYRPG--LPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 1364

  Fly  1171 YTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKE 1235
            .:.|.||:|..||.|:.|..||.|::||||||.|||||:|.||||...:.|..||..|::..|.|
Human  1365 PSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSE 1429

  Fly  1236 VVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSK 1300
            |::.: .||..::.|||.:.|:|||||:|||||:|.:.:||.:|||||:||.:||.|:|.||..:
Human  1430 VITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKR 1493

  Fly  1301 FRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEGL 1363
            |.:.|||||||||:||::||:|:|:.||||||..||..|..:.     |:|..|..::|.:|:
Human  1494 FANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQP-----HSLFQQLLQSSQQGV 1551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 415/1334 (31%)
ABC_membrane 171..437 CDD:294371 66/268 (25%)
ABCC_MRP_domain1 499..699 CDD:213217 88/202 (44%)
ABC_membrane 799..1045 CDD:294371 69/282 (24%)
ABCC_MRP_domain2 1115..1336 CDD:213211 116/221 (52%)
ABCC10XP_016866934.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151627
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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