Protein Alignment l(2)03659 and ABCC10

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_054212675.1
• Gene: ABCC10 / 89845
• HGNCID: 52
• Length: 1543
• Species: Homo sapiens
• Alignment Length: 1353
• Identity: 424/1353 - (31%)
• Similarity: 688/1353 - (50%)
• Gaps: 139/1353 - (10%)

  Fly    82 KEKVLPENPRAR-----SNFISSLCFWYTIPIFRKGYRKTL-DSTDLYRPLEEQKSDILGNRLCA 140
            :|.:|||:....     .:::|...:.:..|:..:|....| ...|:.|.....:...|.....|
Human   252 QEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQA 316

  Fly   141 SWE------RELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGE 199
            .|:      |.|........|...||::.|..|||.|              |:.|..|:.:....
Human   317 HWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSG--------------PLLLSLLVGFLEEG 367

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSG 264
            .:..:.|..||:.....:.|..::.....:.::.|..:.|.|:.::::.|||:|....   ..:|
Human   368 QEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTG 429

  Fly   265 HVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTR 329
            ..:||:..|..||.:...:.|..|..|||:.:..||:||::|::.|.|::..||.:|:...:.||
Human   430 EALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATR 494

  Fly   330 TSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRG---F 391
            ..|...:..:..|.|:::|.|::|.|:|:|...|||.....|...|.:|:..:|..:|:..   :
Human   495 IMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVY 559

  Fly   392 DFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIR 456
            .:|...|:..:.||::   ||::|...|....|...|...:|:..::.: |..|....:...|:.
Human   560 LWAALPVVISIVIFIT---YVLMGHQLTATKVFTALALVRMLILPLNNF-PWVINGLLEAKVSLD 620

  Fly   457 RVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGIN 521
            |::.|:   :|.:.:.....|.|     ||:..:      :.:.:......|||..........:
Human   621 RIQLFL---DLPNHNPQAYYSPD-----PPAEPS------TVLELHGALFSWDPVGTSLETFISH 671

  Fly   522 LEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNG---SLSYTSQESWLFSGTVRQNIL 583
            ||:|.|.:|.::|..|.|||||:.||.|||....|.:.|.|   .....:||.|:...|:|.|||
Human   672 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNIL 736

  Fly   584 FGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLD 648
            ||:..|:|.|:||::.|||..|..:||..|.|.|||:|.||||||:|||:|||:||::..:||||
Human   737 FGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLD 801

  Fly   649 DPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTG 713
            |||:||||.||.||..:|:.|.|..:|.:|.||:.::|...|.::::..|::...|....:|..
Human   802 DPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPL- 865

  Fly   714 LITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGG-----SSSGK-EHVERQES 772
                   :....||..|       |..::.:......:|.|:|..|     |:||: ...|.::.
Human   866 -------VQAVPKAWAE-------NGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKE 916

  Fly   773 GGISLALYRKYFQA-GGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMES- 835
            |.::|.:|:.|::| |.||.  |.:|.|.:|.|......|::|::|:.:........|.:...|
Human   917 GAVALHVYQAYWKAVGQGLA--LAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSP 979

  Fly   836 KSMDVYKYTLII-----------------------------ILSVIMNLSSSFLLFNI------A 865
            .||.::...|::                             :.:.|..::|...|...      .
Human   980 ASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGT 1044

  Fly   866 KKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIII 930
            .:|:..||..:.:||..|.:.||:....|.|||||:.|::..|:.||.:|..::..|..|.|::.
Human  1045 LQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLA 1109

  Fly   931 VIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQ 995
            |:.:..|.||:....||:::||::..|..:||:|:|:.::..||:|||||.:|.||:.:||..|.
Human  1110 VLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGAT 1174

  Fly   996 RVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIIT-LSFFAFPPG--NGADVGLVI 1057
            ...|:|.....:.:....|...:|.|.....:..:....:|.|. ::......|  |...|||.:
Human  1175 YRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSL 1239

  Fly  1058 TQAMGLIDMVQWGVRQTAELENTMTAVERVVEYE---SIEPEGMLEAPDDKKPPKT---WPEQGE 1116
            :.|:.|..::...|....:.|..:.:|||:.||.   ..||:|        :|.:.   |..||.
Human  1240 SYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG--------QPLQLGTGWLTQGG 1296

  Fly  1117 IIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDT 1180
            :.|:::.|.|.|.  ..|.|..::|.:||.||:|||||||:|||||:..||| |..:.|.||:|.
Human  1297 VEFQDVVLAYRPG--LPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDG 1359

  Fly  1181 RDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLA 1245
            .||.|:.|..||.|::||||||.|||||:|.||||...:.|..||..|::..|.||::.: .||.
Human  1360 VDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLD 1423

  Fly  1246 SKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIA 1310
            .::.|||.:.|:|||||:|||||:|.:.:||.:|||||:||.:||.|:|.||..:|.:.||||||
Human  1424 GELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIA 1488

  Fly  1311 HRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEGL 1363
            |||:||::||:|:|:.||||||..||..|..:.     |:|..|..::|.:|:
Human  1489 HRLNTILNSDRVLVLQAGRVVELDSPATLRNQP-----HSLFQQLLQSSQQGV 1536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	424/1352 (31%)
ABCC10	XP_054212675.1	MRP_assoc_pro	<324..1520	CDD:188098	406/1258 (32%)