DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC3

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_003777.2	Gene:	ABCC3 / 8714	HGNCID:	54	Length:	1527	Species:	Homo sapiens

Alignment Length:	1385	Identity:	469/1385 - (33%)
Similarity:	739/1385 - (53%)	Gaps:	158/1385 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCAS 141
            ||:|......||   ..:.|:|.|.||:...:...|||..|:..||:...||.:|.::..:|..:
Human   198 SAKNVDPNPYPE---TSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259

  Fly   142 WERELKNDG--------------------------RSPSLVRALLRVFGWQLGFPGLAIFVVELG 180
            |.::.|...                          |.||.::|||..||        :.|::...
Human   260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFG--------SSFLISAC 316

  Fly   181 LRTLQPIF------LVKLISYFSGEPDAAN-AGFYYAVAQIVISALTVMILTPTTFGIHHVCF-- 236
            .:.:|.:.      |:.::..|...|.|.: .||..|....:.|.:..:||.    ..:|..|
Human   317 FKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQ----HYYHYIFVT 377

  Fly   237 --KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPR-LDSAPYTVHYLWVGPLQVLVIT 298
              |.|..:..:|:||||.:|......:|.|.:|||:|.|..| :|.||: ::.||..|||:::..
Human   378 GVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF-LNLLWSAPLQIILAI 441

  Fly   299 YLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAW 363
            |.::|.:|.|.:.||.||:|.:|:...:..:..|.|:|..:..|:||::::||::.|:|||:|||
Human   442 YFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAW 506

  Fly   364 EQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL--GKVFTPEIAFMI 426
            |..|.:.|...|:.|:..:|...|:........:....:...::|..||.:  ..|...|.||:.
Human   507 EPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVS 571

  Fly   427 TAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNE 491
            .:.:|:|...::: :|..|....|...|::|::||:..|||   |......|...||
Human   572 VSLFNILRLPLNM-LPQLISNLTQASVSLKRIQQFLSQEEL---DPQSVERKTISPG-------- 624

  Fly   492 ADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSG 556
                 .||:|......|..:.|. ||..:::::..|::|||:|..|.|||||:.|:|||::...|
Human   625 -----YAITIHSGTFTWAQDLPP-TLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEG 683

  Fly   557 QLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERG 621
            ::.:.||::|..|::|:.:.|:::|:|||:.::.:||::.::.|||..|.::||..|.|.:||:|
Human   684 KVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748

  Fly   622 ATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQ 684
            ..|||||:.|:||||:||..|.|:||||||||||:.||:|:||..:  .|.|.|.|.|||||...
Human   749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGIS 813

  Fly   685 FLPHVDQIVILANGQIKALGDYESLL-KTGLITGL----------GSL--SKTDKAKTEEQEPLN 736
            |||..|.|::||:||:..:|.|.:|| :.|.....          |.|  |.|.....|::|.|.
Human   814 FLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALL 878

  Fly   737 L-NSPDNKNEVT---PI-----KENSEQTVGGSSSG--------KEHV----------------- 767
            : ::..|..::|   |:     |:...|....||.|        :.|:
Human   879 IEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGAL 943

  Fly   768 ---ERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGE 829
               |:...|.:.|:::..|.:| .||...|.:....|....|..|.:.:|:.|.        :..
Human   944 TQEEKAAIGTVELSVFWDYAKA-VGLCTTLAICLLYVGQSAAAIGANVWLSAWT--------NDA 999

  Fly   830 MED--MESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINK 892
            |.|  ..:.|:.:..|..:.||...:.:.::..:.....:|:..||..:.:...|:...||....
Human  1000 MADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTP 1064

  Fly   893 HGSILNRFTKDMSQVDEVL-PVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNL 956
            .|.|||.|:||:..||||| ||:|:.:......::.:::::|: .||..|..|.|:|::..::..
Human  1065 SGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAS-TPLFTVVILPLAVLYTLVQRF 1128

  Fly   957 YLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQ 1021
            |..|||.|||:|:::|||:|||.:.::.|.:.|||.:..|..|...|:..||:..:.:.||.:::
Human  1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNR 1193

  Fly  1022 --AFG--YCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMT 1082
              :.|  :..||:.:.......:...:..||.   |||.::.::.:...:.|.:|..::||:.:.
Human  1194 WLSIGVEFVGNCVVLFAALFAVIGRSSLNPGL---VGLSVSYSLQVTFALNWMIRMMSDLESNIV 1255

  Fly  1083 AVERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQ 1144
            |||||.||...|    .|||   :..:||:.||.:||:.|:..::||.|.  .:.||:.||..:.
Human  1256 AVERVKEYSKTE----TEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPG--LDLVLRDLSLHVH 1314

  Fly  1145 PREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGT 1208
            ..|||||||||||||||:...||| |....|.:.||..:...:||||||.|::||||:|:|||||
Human  1315 GGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379

  Fly  1209 MRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILREN 1273
            :|.|||||..||:|.:|..||...|...||..|.||..:.||||.|.|||||||||||||:||::
Human  1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKS 1444

  Fly  1274 RILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYE 1338
            ||||:|||||.:|.:||.|||||||::|..||||||||||:||:|..:|:|:|.|.|.||.||..
Human  1445 RILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPAN 1509

  Fly  1339 LMTKSDSKVFHNLVNQSGRA 1358
            |:....  :|:.:...:|.|
Human  1510 LIAARG--IFYGMARDAGLA 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	461/1356 (34%)
		ABC_membrane	171..437	CDD:294371	79/279 (28%)
		ABCC_MRP_domain1	499..699	CDD:213217	90/201 (45%)
		ABC_membrane	799..1045	CDD:294371	67/252 (27%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	127/221 (57%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	467/1382 (34%)
ABCC3	NP_003777.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..932		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660