DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and VMR1

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_011828.1 Gene:VMR1 / 856350 SGDID:S000001027 Length:1592 Species:Saccharomyces cerevisiae


Alignment Length:1457 Identity:413/1457 - (28%)
Similarity:697/1457 - (47%) Gaps:239/1457 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 RSNFISSLCF------WYT--IP------------------IFRKGYRKTLDSTDLYRPLEEQKS 131
            ||..:.::||      |.:  ||                  ||......||....|..|:::..|
Yeast   191 RSTNLWAICFTAHTTIWISTWIPIRSVYIGNIDDVPSQIFYIFEFVITSTLQPIKLTSPIKDNSS 255

  Fly   132 DILGNRLCASWERELKNDGRSPSL--VRALLRVFGWQ---------------------LGFPGLA 173
            .|.           :::|..|||.  :.::|....|.                     |.....:
Yeast   256 IIY-----------VRDDHTSPSREHISSILSCITWSWITNFIWEAQKNTIKLKDIWGLSMEDYS 309

  Fly   174 IFVVE-------------------------LGLR--------TLQPIFLVKLISYFSGEPDAA-- 203
            ||:::                         :|:.        .|.|..|:|........|:.:  
Yeast   310 IFILKGFTRRNKHINNLTLALFESFKTYLLIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNRSSS 374

  Fly   204 --NAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTS--- 263
              |..:.|.:...:......:..:...|....:|.::|..:...|:.|.||........|:|   
Yeast   375 CMNLAWLYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSD 439

  Fly   264 ------GHVVNLISNDIPRLDSAPYTVHYLWV---GPLQVLVITYLMYQEIGISAVFGVLFMLLF 319
                  |.::||||.|..::..   ..:||:|   ..:.::|:..|::..:|:||..|:..:|:.
Yeast   440 SISANLGTIINLISIDSFKVSE---LANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVM 501

  Fly   320 MPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQ 384
            .|:...|.......|.:..:.||.||..:||.:..|:::|.:|||:.....:...|:||:.::  
Yeast   502 FPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSL-- 564

  Fly   385 GQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVF-----------TPEIAFMITAYYNVL----- 433
                    ..:.:|.|..:....:...::.|..|           ...:||...:.:.:|     
Yeast   565 --------LKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAPLAFTTLSLFTLLKTPLD 621

  Fly   434 -LAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKS 497
             |:.|..::       .|...|::|:..|::      .|.:|..::.|:  :|..|.        
Yeast   622 QLSNMLSFI-------NQSKVSLKRISDFLR------MDDTEKYNQLTI--SPDKNK-------- 663

  Fly   498 AISIRDLKAKWDPNSPD---YTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQ 559
             |..::....|:.|..|   :.|.|:|::.:.|.:..::|.||||||:|:..:||||...||.:.
Yeast   664 -IEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSII 727

  Fly   560 V----------------NGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDL 608
            |                ..|.:|.||.:||.:.||:.||:|....:..||.:|:..|.|:||.::
Yeast   728 VPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEI 792

  Fly   609 LPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHL-R 672
            ||..|.|.:||:|.|||||||.||||||:||..|...||||.|||||:..|..:::.|:.|.| :
Yeast   793 LPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGPLMK 857

  Fly   673 GSTVVLVTHQEQF-LPHVDQIVILANGQIKALGDYESLLKTGLI-TGLGSLSKTDKAKTEEQEPL 735
            ..|.:||||.... |.:....::|.||::|..|....|...||. .....||..|....:....|
Yeast   858 NRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLFKEKYVQLSSRDSINEKNANRL 922

  Fly   736 NLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQES-GGISLALYRKYFQAGGGLVAFLVMLSS 799
            .....::..::.|:.||........:.|:...|.::| |.||..:|:.|.:..||..|...:.:.
Yeast   923 KAPRKNDSQKIEPVTENINFDANFVNDGQLIEEEEKSNGAISPDVYKWYLKFFGGFKALTALFAL 987

  Fly   800 SVLAQVAVTGGDYFLTYWVKKES---TAAG--------HGEMEDMESKSMDVYKYTLIIILSVIM 853
            .:.||:......:::.:||...:   .|.|        .|..:..::|....|..|:..::.:|.
Yeast   988 YITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQ 1052

  Fly   854 NLSSSF---LLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVD-EVLPVV 914
            .:...|   :.|....:||.::.|.:.:.|..|.:.||.:...|.|:|||:||:..|| |::|.:
Yeast  1053 AMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYL 1117

  Fly   915 LVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHL 979
            .|.:..: :..|.||.:|..:.|..|...:::.|:::.:...||..||:|||:::|.:||::.|.
Yeast  1118 EVTIFCL-IQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHF 1181

  Fly   980 AASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFA 1044
            :.:|.|:.||||...:|....|..:..|.::.|||....|.:.|.:.::.|.. :|.:.:.||..
Yeast  1182 SETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGA-FIVLASGSFIL 1245

  Fly  1045 FPPGNGADV-----GLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDD 1104
            .   |.|::     |:.:|.|:...|...|.||..:..|..|.:|||:.||.|||.|..|...:.
Yeast  1246 L---NIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQENYLGHDEG 1307

  Fly  1105 K-----KPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLIN 1164
            :     :|  :||:.|||..:.|:|||.||...  |::::||.:.|:.|:|||||||||||::|.
Yeast  1308 RILLLNEP--SWPKDGEIEIENLSLRYAPNLPP--VIRNVSFKVDPQSKIGIVGRTGAGKSTIIT 1368

  Fly  1165 ALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCL 1228
            |||| |....|.:.||.:|..::.|..|||.|:||||:|:||:||::.|:||:|||.::|::..|
Yeast  1369 ALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKAL 1433

  Fly  1229 EEVKL------KEVVSDLPD---------GLASKISEGGTNFSVGQRQLVCLARAILRENRILVM 1278
            .:|.|      :||::....         .|.::|:|||.|.|.|:|||:.:||::|||.:|:::
Yeast  1434 SQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILL 1498

  Fly  1279 DEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKS 1343
            ||||:::|..:|.|||..|||:|...|:|||||||.::||.|:::|||||.|.|:..|.||: |.
Yeast  1499 DEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELL-KD 1562

  Fly  1344 DSKVFHNLVNQSGRASYEGLLKIAQET 1370
            :..:|:::...||  ..|.|.:||:::
Yeast  1563 ERGIFYSMCRDSG--GLELLKQIAKQS 1587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 405/1428 (28%)
ABC_membrane 171..437 CDD:294371 60/331 (18%)
ABCC_MRP_domain1 499..699 CDD:213217 85/220 (39%)
ABC_membrane 799..1045 CDD:294371 68/260 (26%)
ABCC_MRP_domain2 1115..1336 CDD:213211 109/236 (46%)
VMR1NP_011828.1 MRP_assoc_pro 212..1575 CDD:188098 402/1420 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344664
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1734
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.590

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