Protein Alignment l(2)03659 and VMR1

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_011828.1
• Gene: VMR1 / 856350
• SGDID: S000001027
• Length: 1592
• Species: Saccharomyces cerevisiae
• Alignment Length: 1457
• Identity: 413/1457 - (28%)
• Similarity: 697/1457 - (47%)
• Gaps: 239/1457 - (16%)

  Fly    93 RSNFISSLCF------WYT--IP------------------IFRKGYRKTLDSTDLYRPLEEQKS 131
            ||..:.::||      |.:  ||                  ||......||....|..|:::..|
Yeast   191 RSTNLWAICFTAHTTIWISTWIPIRSVYIGNIDDVPSQIFYIFEFVITSTLQPIKLTSPIKDNSS 255

  Fly   132 DILGNRLCASWERELKNDGRSPSL--VRALLRVFGWQ---------------------LGFPGLA 173
            .|.           :::|..|||.  :.::|....|.                     |.....:
Yeast   256 IIY-----------VRDDHTSPSREHISSILSCITWSWITNFIWEAQKNTIKLKDIWGLSMEDYS 309

  Fly   174 IFVVE-------------------------LGLR--------TLQPIFLVKLISYFSGEPDAA-- 203
            ||:::                         :|:.        .|.|..|:|........|:.:
Yeast   310 IFILKGFTRRNKHINNLTLALFESFKTYLLIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNRSSS 374

  Fly   204 --NAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTS--- 263
              |..:.|.:...:......:..:...|....:|.::|..:...|:.|.||........|:|
Yeast   375 CMNLAWLYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSD 439

  Fly   264 ------GHVVNLISNDIPRLDSAPYTVHYLWV---GPLQVLVITYLMYQEIGISAVFGVLFMLLF 319
                  |.::||||.|..::..   ..:||:|   ..:.::|:..|::..:|:||..|:..:|:.
Yeast   440 SISANLGTIINLISIDSFKVSE---LANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVM 501

  Fly   320 MPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQ 384
            .|:...|.......|.:..:.||.||..:||.:..|:::|.:|||:.....:...|:||:.::
Yeast   502 FPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSL-- 564

  Fly   385 GQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVF-----------TPEIAFMITAYYNVL----- 433
                    ..:.:|.|..:....:...::.|..|           ...:||...:.:.:|
Yeast   565 --------LKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAPLAFTTLSLFTLLKTPLD 621

  Fly   434 -LAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKS 497
             |:.|..::       .|...|::|:..|::      .|.:|..::.|:  :|..|.
Yeast   622 QLSNMLSFI-------NQSKVSLKRISDFLR------MDDTEKYNQLTI--SPDKNK-------- 663

  Fly   498 AISIRDLKAKWDPNSPD---YTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQ 559
             |..::....|:.|..|   :.|.|:|::.:.|.:..::|.||||||:|:..:||||...||.:.
Yeast   664 -IEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSII 727

  Fly   560 V----------------NGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDL 608
            |                ..|.:|.||.:||.:.||:.||:|....:..||.:|:..|.|:||.::
Yeast   728 VPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEI 792

  Fly   609 LPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHL-R 672
            ||..|.|.:||:|.|||||||.||||||:||..|...||||.|||||:..|..:::.|:.|.| :
Yeast   793 LPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGPLMK 857

  Fly   673 GSTVVLVTHQEQF-LPHVDQIVILANGQIKALGDYESLLKTGLI-TGLGSLSKTDKAKTEEQEPL 735
            ..|.:||||.... |.:....::|.||::|..|....|...||. .....||..|....:....|
Yeast   858 NRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLFKEKYVQLSSRDSINEKNANRL 922

  Fly   736 NLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQES-GGISLALYRKYFQAGGGLVAFLVMLSS 799
            .....::..::.|:.||........:.|:...|.::| |.||..:|:.|.:..||..|...:.:.
Yeast   923 KAPRKNDSQKIEPVTENINFDANFVNDGQLIEEEEKSNGAISPDVYKWYLKFFGGFKALTALFAL 987

  Fly   800 SVLAQVAVTGGDYFLTYWVKKES---TAAG--------HGEMEDMESKSMDVYKYTLIIILSVIM 853
            .:.||:......:::.:||...:   .|.|        .|..:..::|....|..|:..::.:|.
Yeast   988 YITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQ 1052

  Fly   854 NLSSSF---LLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVD-EVLPVV 914
            .:...|   :.|....:||.::.|.:.:.|..|.:.||.:...|.|:|||:||:..|| |::|.:
Yeast  1053 AMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYL 1117

  Fly   915 LVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHL 979
            .|.:..: :..|.||.:|..:.|..|...:::.|:::.:...||..||:|||:::|.:||::.|.
Yeast  1118 EVTIFCL-IQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHF 1181

  Fly   980 AASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFA 1044
            :.:|.|:.||||...:|....|..:..|.::.|||....|.:.|.:.::.|.. :|.:.:.||..
Yeast  1182 SETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGA-FIVLASGSFIL 1245

  Fly  1045 FPPGNGADV-----GLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDD 1104
            .   |.|::     |:.:|.|:...|...|.||..:..|..|.:|||:.||.|||.|..|...:.
Yeast  1246 L---NIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQENYLGHDEG 1307

  Fly  1105 K-----KPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLIN 1164
            :     :|  :||:.|||..:.|:|||.||...  |::::||.:.|:.|:|||||||||||::|.
Yeast  1308 RILLLNEP--SWPKDGEIEIENLSLRYAPNLPP--VIRNVSFKVDPQSKIGIVGRTGAGKSTIIT 1368

  Fly  1165 ALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCL 1228
            |||| |....|.:.||.:|..::.|..|||.|:||||:|:||:||::.|:||:|||.::|::..|
Yeast  1369 ALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKAL 1433

  Fly  1229 EEVKL------KEVVSDLPD---------GLASKISEGGTNFSVGQRQLVCLARAILRENRILVM 1278
            .:|.|      :||::....         .|.::|:|||.|.|.|:|||:.:||::|||.:|:::
Yeast  1434 SQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILL 1498

  Fly  1279 DEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKS 1343
            ||||:::|..:|.|||..|||:|...|:|||||||.::||.|:::|||||.|.|:..|.||: |.
Yeast  1499 DEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELL-KD 1562

  Fly  1344 DSKVFHNLVNQSGRASYEGLLKIAQET 1370
            :..:|:::...||  ..|.|.:||:::
Yeast  1563 ERGIFYSMCRDSG--GLELLKQIAKQS 1587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	413/1454 (28%)
VMR1	NP_011828.1	MRP_assoc_pro	212..1575	CDD:188098	402/1420 (28%)