DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)03659 and YKR104W

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	315	Identity:	134/315 - (42%)
Similarity:	201/315 - (63%)	Gaps:	33/315 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1081 MTAVERVVEYESI--EPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
            |::|||:.||..|  |..|.:      .||..||:.|::..|.|:|||:|:  :...|.::||.:
Yeast     1 MSSVERIKEYTDIPSESNGYI------SPPANWPQTGDVELKNLSLRYSPH--SSKALDNVSFKV 57

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRLS-YTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            :...||||||||||||||:|.|::||| :.:|::.||.:|.:.:.|..||..||.|||:|.||.|
Yeast    58 KAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDG 122

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDL--------PD-----------GLASKISEGGT 1253
            |:|.||||||.|||.:::|.|.:|.|.|...:|        |:           .|.:.:..||:
Yeast   123 TVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGS 187

  Fly  1254 NFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIID 1318
            |.|.|||||:||||::|....|:::|||||::|..:|..||.|||...::.|:|||||||.::||
Yeast   188 NLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVID 252

  Fly  1319 SDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRASYEGLLKIAQETFES 1373
            .||::||:.|||.|:..||.|::..:: :|:.|..|||  .:|.|.::|:.:|::
Yeast   253 YDKILVMEMGRVKEYDHPYTLISDRNT-IFYRLCRQSG--EFENLFELAKVSFDN 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	125/283 (44%)
		ABC_membrane	171..437	CDD:294371
		ABCC_MRP_domain1	499..699	CDD:213217
		ABC_membrane	799..1045	CDD:294371
		ABCC_MRP_domain2	1115..1336	CDD:213211	109/240 (45%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	111/244 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740