DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and NFT1

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_013029.3	Gene:	NFT1 / 853978	SGDID:	S000001811	Length:	1218	Species:	Saccharomyces cerevisiae

Alignment Length:	1064	Identity:	266/1064 - (25%)
Similarity:	465/1064 - (43%)	Gaps:	206/1064 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ENCKQKLTVNSENNSAQNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLE 127
            |..:....|.:||        |.||..|    .....|.|.....:..|.|:..|.:.|:: .|:
Yeast   227 EGTRYSFLVENEN--------KKLPPAP----TVFGLLTFSRIDRLIWKAYKHCLGNADIW-DLD 278

  Fly   128 EQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKL 192
            .....|   .:.|::|...|.....|:::.....||..||....::.|     |..:..:.:.::
Yeast   279 INNKSI---AILANFEMSSKKGRLLPNIICYFKAVFISQLFLAFVSSF-----LNFVPSLLMPRI 335

  Fly   193 ISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVC------------FKMRVAMGSM 245
            :||.: :|.:.:    :.:..:.:|::.|..:..||      |            .::|..:.|.
Yeast   336 LSYVN-DPKSKS----WNLVSLYVSSMLVSKIIATT------CRGQGLFLGEKGTMQLRTVLISN 389

  Fly   246 IFRKALRLTKGALGDTTS-----------------------------GHVVNLISNDIPRLDSAP 281
            |:.|.||.|  .|.|:|:                             ..|.|::|.|..::..|.
Yeast   390 IYSKTLRRT--ILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAM 452

  Fly   282 YTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIR 346
            .|.:.........:....::|..:|.||..|...:|..:|:..:..|.....|......||.|..
Yeast   453 NTFYLACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTS 517

  Fly   347 MVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGY 411
            .::|.:::|:|:|:.|||..|.|.:.:.|:.|:..:::...|   .|...::.......:|.:.:
Yeast   518 GISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATI---FFLNHLIWFFGPTLVSAITF 579

  Fly   412 VIL----GKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDK 472
            .:.    .:..||.|||...:.:.:|...|. .:.|.:....|...|:.|::.::...|....:.
Yeast   580 SVFIKFQNQTLTPTIAFTALSLFAILRTPMD-QIASTVSLLIQSFISLERIQDYLNESETRKYEI 643

  Fly   473 SEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTG 537
            .|           .||        :.....|...:|:.....:.|..|:::.|..|:.|:||.||
Yeast   644 LE-----------QSN--------TKFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTG 689

  Fly   538 SGKSSLIQAILGELKANSGQLQV----------------NGSLSYTSQESWLFSGTVRQNILFGQ 586
            ||||||:..:||||...||::.|                ..|::|.||..||.|||::.|::||:
Yeast   690 SGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGE 754

  Fly   587 PMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPL 651
            ..:.|::::|:|.|.|::|...:.....|.||:.|.:|||||:.||:|||::|..:...:|||.|
Yeast   755 IFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCL 819

  Fly   652 SAVDASVARHLFDQCVRG-HLRGSTVVLVTHQEQFL-PHVDQIVILANGQIKALGDYESLLKTG- 713
            ||||...|.:::::|:.| .::|.|.::.:|....: ...|.:|||..|::|:.|....|:|:.
Yeast   820 SAVDPETALYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQGKPSDLIKSNE 884

  Fly   714 -LITGLGSLSK------------TDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKE 765
             |...:.:.||            |...||:..:|...||.|   ||....||.|:|
Yeast   885 FLRESINNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQD---EVCAEVENFEET--------- 937

  Fly   766 HVERQESGGISLALYR---KYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGH 827
                :..|.:..:.|:   .||   |||....|..|||:|.........::|.||:...|:.
Yeast   938 ----KMEGSVKFSAYKWLADYF---GGLGVVFVFTSSSILIHGITLSQGFWLRYWLDTGSSG--- 992

  Fly   828 GEMEDMESKSMDVYKYT------LIIILSVIMNLSSSFLL-----------FNIAKKASIRLHNT 875
                   |||..:|:..      ..::..:|:.|.||||.           .|:.||...:|.::
Yeast   993 -------SKSTWLYRIVEGHSNIYFLLTYIIIGLVSSFLTSGKVWIAIISGTNVTKKIFAKLLSS 1050

  Fly   876 IFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVL---------PVVLVDVMQIALWLAGIIIV 931
            |.    .|.:.|.::...|.|:|||:|||..:|:.|         .||      :.||   ||::
Yeast  1051 IL----YAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVV------VCLW---IILL 1102

  Fly   932 IANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRAL-DAQ 995
            |..|.|..|:..:.|..::|.:..|||:.||:|||::.||.||::...|.::.|:|||||| |.:
Yeast  1103 IGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADER 1167

  Fly   996 RVLEKEFDSYQDAHSSAFFMYIST 1019
            |.:.:...:...:::..|::.::|
Yeast  1168 RFITQSLVAIDRSNAPFFYLNMAT 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	259/1038 (25%)
		ABC_membrane	171..437	CDD:294371	58/310 (19%)
		ABCC_MRP_domain1	499..699	CDD:213217	75/217 (35%)
		ABC_membrane	799..1045	CDD:294371	70/248 (28%)
		ABCC_MRP_domain2	1115..1336	CDD:213211
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	258/1027 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344665
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830