DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and STE6

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_012713.1 Gene:STE6 / 853671 SGDID:S000001692 Length:1290 Species:Saccharomyces cerevisiae


Alignment Length:1366 Identity:301/1366 - (22%)
Similarity:542/1366 - (39%) Gaps:332/1366 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 LISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRL--- 253
            |:|.|..  :.::.|.|   :|:|..::.||.|...:..:..:.....:.:|.   |:..|:   
Yeast    54 LLSVFVA--NGSHQGLY---SQLVQRSMAVMALGAASVPVMWLSLTSWMHIGE---RQGFRIRSQ 110

  Fly   254 ----------------TKGALGDTTSGHVVNLISNDIPRLDSAPYTV-----------------H 285
                            .:..|||.|.   :|....:: |..||..:.                 :
Yeast   111 ILEAYLEEKPMEWYDNNEKLLGDFTQ---INRCVEEL-RSSSAEASAITFQNLVAICALLGTSFY 171

  Fly   286 YLWVGPLQVL----VITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIR 346
            |.|...|.:|    :||:           |.|:|..:   |.:|        ..|....|....:
Yeast   172 YSWSLTLIILCSSPIITF-----------FAVVFSRM---IHVY--------SEKENSETSKAAQ 214

  Fly   347 MVNEIISAIQVLKMYAWE----QPFEQMVTHAREKEMNTIRQGQYIRG--FDFARRIVLSRVAIF 405
            ::...::|.|::::|..:    :.|::::.:.     ||.    :|:.  |..|...:|..:.:.
Yeast   215 LLTWSMNAAQLVRLYCTQRLERKKFKEIILNC-----NTF----FIKSCFFVAANAGILRFLTLT 270

  Fly   406 LSLVGY------VILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRR----VEQ 460
            :.:.|:      :..||:   .|..:||.:::.::      :.|.:..|...:..:::    :|:
Yeast   271 MFVQGFWFGSAMIKKGKL---NINDVITCFHSCIM------LGSTLNNTLHQIVVLQKGGVAMEK 326

  Fly   461 FMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSP-DYTLSGINLEI 524
            .|...:.||   ...|...||....|.:...:||..:.:|..      .|:.| :..|..::|..
Yeast   327 IMTLLKDGS---KRNPLNKTVAHQFPLDYATSDLTFANVSFS------YPSRPSEAVLKNVSLNF 382

  Fly   525 KPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNG-------------SLSYTSQESWLFSG 576
            ..|....::|.:|||||:|...:|......:|.:.:||             :::...|...||:.
Yeast   383 SAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFND 447

  Fly   577 TVRQNILFGQPMDSQR------------YEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQK 629
            |:|:|||.|. .||.|            .::..:...|:|....||....|::|..|.||||||:
Yeast   448 TLRKNILLGS-TDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQ 511

  Fly   630 ARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVI 694
            .|:::||:..|...|..||:.:||:|. |.|:|..:.:|...:|.|.:::||:...:...|.:.:
Yeast   512 QRVAIARAFIRDTPILFLDEAVSALDI-VHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYL 575

  Fly   695 LANGQIKALGDYESLL---KTGLITGLGSLSKTDKAK------TEEQ-----EPLN--LNSP--- 740
            :..|::...|....||   .|...|.....:....||      |||:     |..|  |.:|   
Yeast   576 MKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLG 640

  Fly   741 ----------------------DNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGISLAL---- 779
                                  ...|..|...:..|:.:|.:...:::.| ..:|...|::    
Yeast   641 SCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTE-SSTGPQLLSIIQII 704

  Fly   780 --------YRKYFQAG--GGLVA----------FLVMLSSSVLAQVAVTGGDYFLTYWVKKESTA 824
                    |:|....|  ..|:|          |..:|...|.:....||..::|..|       
Yeast   705 KRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKW------- 762

  Fly   825 AGHGEMEDMESKSMDVYKYTLIIILSV-----IMNLSSSFLLFNIAKKASIRLHNTIFNRVTRAD 884
                                .:::|.|     |.|.:..|||...::...:.|.|.:..::||.:
Yeast   763 --------------------SLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKN 807

  Fly   885 MHFFS--INKHGSI----LNRFTKDMSQVDEVLPVV--LVDVMQIAL-W--LAG--IIIVIANVN 936
            |.:||  .||...|    ||......|.|.|.|..:  .|.|..|.| |  ::|  :.:|..::.
Yeast   808 MDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMF 872

  Fly   937 PLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKE 1001
            ||:::    .|.|:   ..:..|...|.|...|...:.:|.    .:..:.||:.|.|      |
Yeast   873 PLIII----FSAIY---GGILQKCETDYKTSVAQLENCLYQ----IVTNIKTIKCLQA------E 920

  Fly  1002 FDSYQDAHSSAFFM-YISTSQA----FGYCMN-----CI-CVIY-----------------ISII 1038
            |......|.....| .|::.:|    ||..|.     || .:||                 .:..
Yeast   921 FHFQLTYHDLKIKMQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTF 985

  Fly  1039 TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYE-----SIEPEGM 1098
            ||..|..         :..|..:..|..:..|.|..:.:...:......:|.|     ::...|.
Yeast   986 TLLLFTI---------MSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLEVENNNARTVGIAGH 1041

  Fly  1099 LEAPDDKKPPKTWPEQGEIIFKELNLRYT-PNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSL 1162
            .....:|||          |....||.:. |:|....|.|:::|.:...:.:||:|.:|.|||:|
Yeast  1042 TYHGKEKKP----------IVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTL 1096

  Fly  1163 INALFRLSYTD-GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNL--DPFDEYSDEKL 1224
            :..|.:|...: |.:.||..|.....|..||::||::.|:|:||:||:|.||  ...||..:.::
Yeast  1097 VLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEM 1161

  Fly  1225 WGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQT 1289
            :..|:.|.:.:.|...|.||.::|..  |..|.||.|.:|:|||:||:::||::||.|:.:|..:
Yeast  1162 YDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQRLCIARALLRKSKILILDECTSALDSVS 1224

  Fly  1290 DGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQ 1354
            ..:|...::........:.|.|....:...:.:.|:..|:|||.|: ::.:..:..::|..:.||
Yeast  1225 SSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGN-FDTLYNNRGELFQIVSNQ 1288

  Fly  1355 S 1355
            |
Yeast  1289 S 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 297/1352 (22%)
ABC_membrane 171..437 CDD:294371 50/296 (17%)
ABCC_MRP_domain1 499..699 CDD:213217 61/225 (27%)
ABC_membrane 799..1045 CDD:294371 64/291 (22%)
ABCC_MRP_domain2 1115..1336 CDD:213211 71/224 (32%)
STE6NP_012713.1 MdlB 24..605 CDD:224055 129/613 (21%)
MdlB 702..1289 CDD:224055 154/652 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.