DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC11

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1365	Identity:	439/1365 - (32%)
Similarity:	707/1365 - (51%)	Gaps:	156/1365 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VLPENPRAR---------SNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLE-EQKSDILGNRLC 139
            ::|..|:.|         :...|.|...:..|:..:..|..||...: .||. ...||....||.
Human    71 MIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTI-PPLSVHDASDKNVQRLH 134

  Fly   140 ASWERELKNDG-RSPSLVRALLRVFGWQLGFPGLAIFVVELGL-----RTLQPIFLV-KLISYFS 197
            ..||.|:...| ...|::..:||....:|.|..|      ||:     ..|.||.:: |::.|
Human   135 RLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDAL------LGICFCIASVLGPILIIPKILEY-- 191

  Fly   198 GEPDAAN----AGFYYA--VAQIV--ISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLT 254
            .|....|    .|..:|  :::.|  :|..:..|:...|      ..:.|.|:.|..|.|.::.
Human   192 SEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRT------AIRFRAAVSSFAFEKLIQF- 249

  Fly   255 KGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLW----VGPLQVLVITYLM------YQEIGISA 309
            |..: ..|||..::..:.|          |:||:    .|||.::....|:      |..||.:|
Human   250 KSVI-HITSGEAISFFTGD----------VNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTA 303

  Fly   310 VFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHA 374
            ...:|..||..|:.:::.......|...:|.:|.|||:.:|:::.|:::|||.||:||.:::...
Human   304 FIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDL 368

  Fly   375 REKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSI 439
            |.||...:.:...::........::..||..:.::.:..|....|..:||.:.|..|:|..:: .
Human   369 RRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSV-F 432

  Fly   440 YVPSAIIQTAQFLTSIRRVEQ-FMQSEELGSSDKSEGPSK------------DTVPGNPPSNNNE 491
            :||.|:.......:::.|.:: |:|...:......:.|||            .|.||
Human   433 FVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPG-------- 489

  Fly   492 ADLLKSAISI-------------RD-LKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSS 542
              ::..|:.:             || |..:.:.||....|..|||.:..|.::.|.|.|||||||
Human   490 --IVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSS 552

  Fly   543 LIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFD 607
            |:.|||.|:....|.:.|.|||:|..|::|:.||.:|:|||.|...|..||.:|:..|:|.||.:
Human   553 LLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

  Fly   608 LLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLR 672
            |||..|.|.:||||..||||||.||||||:||....|||||||||||||.|.:|:|::|::..||
Human   618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLR 682

  Fly   673 GSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL-KTGLITGLGSLSKTDKAKTEE--QEP 734
            |.||||||||.|:|....||::|.||:|...|.:..|: |.|....|  :.|..|..|.:  |:.
Human   683 GKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQL--IQKMHKEATSDMLQDT 745

  Fly   735 LNLNSPDNKNEVTPIKENSEQTVGGSSSG-KEH----VERQESGGISLALYRKYFQAGGGLVAFL 794
            ..: :...|.|...:..:.|:::.|::.. .||    .|..|.|.:|..:|..|.||.||.:...
Human   746 AKI-AEKPKVESQALATSLEESLNGNAGNVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSC 809

  Fly   795 VMLSSSVLAQVAVTGGDYFLTYWVKK----ESTAAGHGEMEDM----ESKSMDVYK--YTLIIIL 849
            ::....||.........::|:||:::    .|:...:|.|.|:    ::..:..|:  |.|..:|
Human   810 IIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL 874

  Fly   850 SVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVV 914
            .:.:.:.||.:...:.:|||..|||.:||:|.|..|.||.....|.:||.|..|:.|:|::||:.
Human   875 LICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIF 939

  Fly   915 LVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHL 979
            ....:.::|.:..::::::.::|.:|:...::.||.:....::.|.....||:|..:|||::||:
Human   940 SEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHI 1004

  Fly   980 AASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLS--- 1041
            ..||.||::|...........:|....||.::...:::|:::.....:.    |..:::||:
Human  1005 LNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLE----IMTNLVTLAVAL 1065

  Fly  1042 FFAFPPGNGADVGLVIT------QAMGLIDMVQWGVRQTA----ELENTMTAVERVVEYESIEPE 1096
            |.||        |:..|      .|:.::..:....:.||    |.|...|||||:::|..:
Human  1066 FVAF--------GISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKM--- 1119

  Fly  1097 GMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAG 1158
            .:.|||   :....|:.||:.|||||::.:::|..|  ...||..::..|:..|.||||||||:|
Human  1120 CVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDN--TPTVLHGINLTIRGHEVVGIVGRTGSG 1182

  Fly  1159 KSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDE 1222
            ||||..||||| ....|.:|||..|...:||.|||.::|:|||:|||.|||:|:||||||.::|:
Human  1183 KSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQ 1247

  Fly  1223 KLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDP 1287
            ::|..||...|.:.:|..|..|.:.:.|.|.|||||:|||:|:|||:||.::|:::|||||::|.
Human  1248 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDM 1312

  Fly  1288 QTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            :||.|||.|||..|:.||||.||||:.|:::.|.::||..|:||||..| |::.|....:|..|:
Human  1313 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRP-EVLRKKPGSLFAALM 1376

Fly 1353 1352
Human 1377 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	435/1350 (32%)
		ABC_membrane	171..437	CDD:294371	68/289 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	104/213 (49%)
		ABC_membrane	799..1045	CDD:294371	64/258 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	113/221 (51%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	434/1346 (32%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650