Protein Alignment l(2)03659 and ABCC11

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001357425.1
• Gene: ABCC11 / 85320
• HGNCID: 14639
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 1365
• Identity: 439/1365 - (32%)
• Similarity: 707/1365 - (51%)
• Gaps: 156/1365 - (11%)

  Fly    85 VLPENPRAR---------SNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLE-EQKSDILGNRLC 139
            ::|..|:.|         :...|.|...:..|:..:..|..||...: .||. ...||....||.
Human    71 MIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTI-PPLSVHDASDKNVQRLH 134

  Fly   140 ASWERELKNDG-RSPSLVRALLRVFGWQLGFPGLAIFVVELGL-----RTLQPIFLV-KLISYFS 197
            ..||.|:...| ...|::..:||....:|.|..|      ||:     ..|.||.:: |::.|
Human   135 RLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDAL------LGICFCIASVLGPILIIPKILEY-- 191

  Fly   198 GEPDAAN----AGFYYA--VAQIV--ISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLT 254
            .|....|    .|..:|  :::.|  :|..:..|:...|      ..:.|.|:.|..|.|.::.
Human   192 SEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRT------AIRFRAAVSSFAFEKLIQF- 249

  Fly   255 KGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLW----VGPLQVLVITYLM------YQEIGISA 309
            |..: ..|||..::..:.|          |:||:    .|||.::....|:      |..||.:|
Human   250 KSVI-HITSGEAISFFTGD----------VNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTA 303

  Fly   310 VFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHA 374
            ...:|..||..|:.:::.......|...:|.:|.|||:.:|:::.|:::|||.||:||.:::...
Human   304 FIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDL 368

  Fly   375 REKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSI 439
            |.||...:.:...::........::..||..:.::.:..|....|..:||.:.|..|:|..:: .
Human   369 RRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSV-F 432

  Fly   440 YVPSAIIQTAQFLTSIRRVEQ-FMQSEELGSSDKSEGPSK------------DTVPGNPPSNNNE 491
            :||.|:.......:::.|.:: |:|...:......:.|||            .|.||
Human   433 FVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPG-------- 489

  Fly   492 ADLLKSAISI-------------RD-LKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSS 542
              ::..|:.:             || |..:.:.||....|..|||.:..|.::.|.|.|||||||
Human   490 --IVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSS 552

  Fly   543 LIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFD 607
            |:.|||.|:....|.:.|.|||:|..|::|:.||.:|:|||.|...|..||.:|:..|:|.||.:
Human   553 LLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

  Fly   608 LLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLR 672
            |||..|.|.:||||..||||||.||||||:||....|||||||||||||.|.:|:|::|::..||
Human   618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLR 682

  Fly   673 GSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL-KTGLITGLGSLSKTDKAKTEE--QEP 734
            |.||||||||.|:|....||::|.||:|...|.:..|: |.|....|  :.|..|..|.:  |:.
Human   683 GKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQL--IQKMHKEATSDMLQDT 745

  Fly   735 LNLNSPDNKNEVTPIKENSEQTVGGSSSG-KEH----VERQESGGISLALYRKYFQAGGGLVAFL 794
            ..: :...|.|...:..:.|:::.|::.. .||    .|..|.|.:|..:|..|.||.||.:...
Human   746 AKI-AEKPKVESQALATSLEESLNGNAGNVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSC 809

  Fly   795 VMLSSSVLAQVAVTGGDYFLTYWVKK----ESTAAGHGEMEDM----ESKSMDVYK--YTLIIIL 849
            ::....||.........::|:||:::    .|:...:|.|.|:    ::..:..|:  |.|..:|
Human   810 IIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL 874

  Fly   850 SVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVV 914
            .:.:.:.||.:...:.:|||..|||.:||:|.|..|.||.....|.:||.|..|:.|:|::||:.
Human   875 LICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIF 939

  Fly   915 LVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHL 979
            ....:.::|.:..::::::.::|.:|:...::.||.:....::.|.....||:|..:|||::||:
Human   940 SEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHI 1004

  Fly   980 AASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLS--- 1041
            ..||.||::|...........:|....||.::...:::|:::.....:.    |..:::||:
Human  1005 LNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLE----IMTNLVTLAVAL 1065

  Fly  1042 FFAFPPGNGADVGLVIT------QAMGLIDMVQWGVRQTA----ELENTMTAVERVVEYESIEPE 1096
            |.||        |:..|      .|:.::..:....:.||    |.|...|||||:::|..:
Human  1066 FVAF--------GISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKM--- 1119

  Fly  1097 GMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAG 1158
            .:.|||   :....|:.||:.|||||::.:::|..|  ...||..::..|:..|.||||||||:|
Human  1120 CVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDN--TPTVLHGINLTIRGHEVVGIVGRTGSG 1182

  Fly  1159 KSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDE 1222
            ||||..||||| ....|.:|||..|...:||.|||.::|:|||:|||.|||:|:||||||.::|:
Human  1183 KSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQ 1247

  Fly  1223 KLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDP 1287
            ::|..||...|.:.:|..|..|.:.:.|.|.|||||:|||:|:|||:||.::|:::|||||::|.
Human  1248 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDM 1312

  Fly  1288 QTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            :||.|||.|||..|:.||||.||||:.|:::.|.::||..|:||||..| |::.|....:|..|:
Human  1313 ETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRP-EVLRKKPGSLFAALM 1376

  Fly  1353  1352
            Human  1377  1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	439/1365 (32%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	434/1346 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..523		4/18 (22%)