DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and YCF1

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_010419.3	Gene:	YCF1 / 851713	SGDID:	S000002542	Length:	1515	Species:	Saccharomyces cerevisiae

Alignment Length:	1337	Identity:	453/1337 - (33%)
Similarity:	714/1337 - (53%)	Gaps:	105/1337 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDGRSP 153
            ||...:|..|.:.|.:...:.:.||.|.|...|||:......|:.|..:|..:||.|||... :|
Yeast   210 NPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENELKQKS-NP 273

  Fly   154 SLVRALLRVFGWQLGFPGLAIF--VVELGLRTLQP---IFLVKLISYFSGEPDAANA-------- 205
            ||..|:.|.||.::   .||.|  .:...|...||   ..|:|.::.::.|....::
Yeast   274 SLSWAICRTFGSKM---LLAAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENN 335

  Fly   206 ---------GFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDT 261
                     ||..|.|..::......:|......:.:....::.|:.::|::|:|.|:..|.|.:
Yeast   336 HPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLS 400

  Fly   262 TSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYL 326
            ::|.:|||:|.|:.:|......::.:|.||.|:::..|.:|:.:|.|...||:.:::.||:..:|
Yeast   401 STGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFL 465

  Fly   327 GTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAR-EKEM-NTIRQGQYIR 389
            ......:|....:..|.|.|:::||::.|:.||:||||:|:.:.:...| .||: |..:.|.|:.
Yeast   466 MRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMA 530

  Fly   390 GFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTS 454
            ...|...||...|:.....|......:..|.::.|.....:|:|...:.| :|..:....:...|
Yeast   531 VTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPLMI-IPMVLNSFIEASVS 594

  Fly   455 IRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDY--TL 517
            |.|:..|..:|||         ..|:|. ..|...|..|:   ||:|.|.........|:|  .|
Yeast   595 IGRLFTFFTNEEL---------QPDSVQ-RLPKVKNIGDV---AINIGDDATFLWQRKPEYKVAL 646

  Fly   518 SGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNI 582
            ..||.:.|.|::..::|..||||::|:..:||:|....|...|:||::|.||..|:.:|||::||
Yeast   647 KNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENI 711

  Fly   583 LFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLL 647
            |||...|::.||:.:|.|||..|..:|...|.|:|||:|.:||||||||:||||:||.:|..|||
Yeast   712 LFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLL 776

  Fly   648 DDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL 710
            ||||:|||..|||||.:..:  .|.|...|.||.|::...|...|.|.:|.||:|...|.|:.:.
Yeast   777 DDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNGEITQQGTYDEIT 841

  Fly   711 K---TGLITGLGSLSKTDKAKTEE--------------------QEPLNLNSPD-NKNEVTPIKE 751
            |   :.|...|.:..|.:..|:.|                    ::...||..| ..::...::.
Yeast   842 KDADSPLWKLLNNYGKKNNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSDAISLRR 906

  Fly   752 NSEQTVGGSSSG-KEHV---ERQESGGISLALYRKYFQAGG--GLVAFLVMLSSSVLAQVAVTGG 810
            .|:.|:|....| .|::   |.:|.|.:...:|.:|.:|..  .:..|::.:..|:...|.   |
Yeast   907 ASDATLGSIDFGDDENIAKREHREQGKVKWNIYLEYAKACNPKSVCVFILFIVISMFLSVM---G 968

  Fly   811 DYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLII----ILSVIMNLSSSFLLFNIAK-KASI 870
            :.:|.:|          .|:......:.:..:|..|.    |.|.:..|..:.:|:.... .||.
Yeast   969 NVWLKHW----------SEVNSRYGSNPNAARYLAIYFALGIGSALATLIQTIVLWVFCTIHASK 1023

  Fly   871 RLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANV 935
            .|||.:.|.|.||.|.||.....|.|||||:.|:.:||.:|..........|:.:...|.||...
Yeast  1024 YLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICAT 1088

  Fly   936 NPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEK 1000
            ....:...:.|||.:.:.:..||:|||:|:|:::|.|||:|||...:|.||.|:|....|:....
Yeast  1089 TWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSH 1153

  Fly  1001 EFDSYQDAHSSAFFMYISTSQAFGYCMNCI-CVIYISIITLSFFAFPPG--NGADVGLVITQAMG 1062
            ......|.:.|||:..|:.::...|.:..| .:|.:...|||.|....|  ....|||.::.|:.
Yeast  1154 INQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQ 1218

  Fly  1063 LIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYT 1127
            :...:.|.||.|.|:|..:.:|||:.||..::.|..| ..:..:|||.||.||:|.|...:.||.
Yeast  1219 ITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPL-IVEGHRPPKEWPSQGDIKFNNYSTRYR 1282

  Fly  1128 PNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDL 1191
            |  :.:.|||.::..|:|.||||||||||||||||..|||| :..::|:::||.....::||:||
Yeast  1283 P--ELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDL 1345

  Fly  1192 RRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKE-VVSDLPDGLASKISEGGTNF 1255
            |.::|||||:..:|.||:|.|:||.::|:||.:|..||...||| |:|...|||.::::|||.|.
Yeast  1346 RHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNL 1410

  Fly  1256 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSD 1320
            |||||||:|||||:|..::|||:|||||.||.:||.::|.|||:.|:|.|:|||||||:||:|||
Yeast  1411 SVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSD 1475

  Fly  1321 KVMVMDAGRVVEFGSPYELMTKSDSK-VFHNLVNQSG 1356
            :::|:|.|:|.||.||.:|:  ||:| :|::|..::|
Yeast  1476 RIIVLDNGKVAEFDSPGQLL--SDNKSLFYSLCMEAG 1510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	447/1321 (34%)
		ABC_membrane	171..437	CDD:294371	70/289 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	91/203 (45%)
		ABC_membrane	799..1045	CDD:294371	73/251 (29%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	119/222 (54%)
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	453/1337 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720