DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)03659 and MDL1

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_013289.1	Gene:	MDL1 / 850885	SGDID:	S000004178	Length:	695	Species:	Saccharomyces cerevisiae

Alignment Length:	754	Identity:	187/754 - (24%)
Similarity:	304/754 - (40%)	Gaps:	182/754 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 TGLGSLSKTDKAKTEEQEPLNLNSPDNK----------NEVTPIKENSEQTV-----GGSSSGKE 765
            :.|.|.....|....::..:||..|..|          :::...|::::.|:     ...|||.:
Yeast    23 SALYSTKSLFKPPMYQKAEINLIIPHRKHFLLRSIRLQSDIAQGKKSTKPTLKLSNANSKSSGFK 87

  Fly   766 HVER------QESGGISLALYRKYFQAGGGLVAFLVMLSSSV-LAQVAVTGGDYFLTYWVKKEST 823
            .::|      .||         ||.    ||...|:::|||| :|..:|.|          |...
Yeast    88 DIKRLFVLSKPES---------KYI----GLALLLILISSSVSMAVPSVIG----------KLLD 129

  Fly   824 AAGHGEMEDME-SKSMDVYKYT---------LIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFN 878
            .|...:.||.| |||..:|.:|         .:.|:..:.|.|...:|....::...||......
Yeast   130 LASESDGEDEEGSKSNKLYGFTKKQFFTALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMK 194

  Fly   879 RVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVD-------------VMQIALWLAGIII 930
            .....|..|...|:.|.:::|.:.|.|.|.:.:...:.|             :|....|....::
Yeast   195 AALDQDATFLDTNRVGDLISRLSSDASIVAKSVTQNVSDGTRAIIQGFVGFGMMSFLSWKLTCVM 259

  Fly   931 VIANVNPLLLVPTLMLSVIFY--HLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALD 993
            :|       |.|.|....:.|  .:|||    ||.|:               .|:.|||
Yeast   260 MI-------LAPPLGAMALIYGRKIRNL----SRQLQ---------------TSVGGLT------ 292

  Fly   994 AQRVLEKEFDSYQDAHSSAFFMYISTSQAFG--------YCMNCICVIYISI---ITLSFFAFPP 1047
              :|.|::.::.:            |.||:|        |......|.:|.:   :|...|.
Yeast   293 --KVAEEQLNATR------------TIQAYGGEKNEVRRYAKEVRNVFHIGLKEAVTSGLFF--- 340

  Fly  1048 GNGADVGLVITQAM-GLI----DMVQWGVRQTAELENTMT------------------------A 1083
               ...|||...|| .|:    .|:|.|.....||.:.|.                        |
Yeast   341 ---GSTGLVGNTAMLSLLLVGTSMIQSGSMTVGELSSFMMYAVYTGSSLFGLSSFYSELMKGAGA 402

  Fly  1084 VERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREK 1148
            ..||.|....:|   |..|...|.|.:. .|..|:||.::..| |......:.|.|:..|:|.|.
Yeast   403 AARVFELNDRKP---LIRPTIGKDPVSL-AQKPIVFKNVSFTY-PTRPKHQIFKDLNITIKPGEH 462

  Fly  1149 VGIVGRTGAGKSSLINALFRLSYTD---GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGT-- 1208
            |..||.:|:|||::.:.|.|  |.|   ||:.....|.|...|...||.|..:.|||:||:||
Yeast   463 VCAVGPSGSGKSTIASLLLR--YYDVNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTIL 525

  Fly  1209 --MRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILR 1271
              :.|.:.|.....|:::...:.:....:.:::.||||.:.:...|...|.||:|.:.||||.|.
Yeast   526 DNILYCIPPEIAEQDDRIRRAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLL 590

  Fly  1272 ENRILVMDEATANVDPQTDGLIQATIRSKF-RDCTVLTIAHRLHTIIDSDKVMVMDA-GRVVEFG 1334
            :..:|::||||:.:|.|::.::...::.:. |..|.::|||||.||..|.:|:|:.. |.|||.|
Yeast   591 DPAVLILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETG 655

  Fly  1335 SPYELMTKSDSKVFHNLVNQSGRASYEGLL----KIAQE 1369
            |..:|:...:|::...|..|.......|::    .:|:|
Yeast   656 SFRDLIAIPNSELNALLAEQQDEEGKGGVIDLDNSVARE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	181/722 (25%)
		ABC_membrane	171..437	CDD:294371
		ABCC_MRP_domain1	499..699	CDD:213217
		ABC_membrane	799..1045	CDD:294371	59/282 (21%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	77/229 (34%)
MDL1	NP_013289.1	MdlB	116..676	CDD:224055	160/628 (25%)
		ABC_membrane	116..386	CDD:279056	69/331 (21%)
		ABC_MTABC3_MDL1_MDL2	432..676	CDD:213216	81/246 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910