DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC11

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001319112.1	Gene:	ABCC11 / 839922	AraportID:	AT1G30420	Length:	1495	Species:	Arabidopsis thaliana

Alignment Length:	1321	Identity:	464/1321 - (35%)
Similarity:	740/1321 - (56%)	Gaps:	96/1321 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NNSAQNEKEKVLPEN----PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILG 135
            |.|..|.:...||..    |...::..|.:.|.:..|:.:.||||.:...|:::..:..:::.|.
plant   209 NESLDNVEYDALPGGVNICPERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLI 273

  Fly   136 NRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGL-RTLQPIFLVKLI-SYFSG 198
            .|....|..|.:..  .|.|:|||....|.:....|  ||.|...| :.:.|:.|..:: |...|
plant   274 KRFQRCWTEESRRP--KPWLLRALNNSLGRRFWLGG--IFKVGHDLSQFVGPVILSHILQSMIEG 334

  Fly   199 EPDAANAGFYYAVAQIVISALTVMILTPTTFGIH--HVCFKMRVAMGSMIFRKALRLTKGALGDT 261
            :|  |..|:.||.  ::...:|..:|..:.:..|  .|.|::|..:.:.||.|:||||..|..:.
plant   335 DP--AWVGYVYAF--LIFFGVTFGVLCQSQYFQHVGRVGFRLRSTLVAAIFHKSLRLTNKARKNF 395

  Fly   262 TSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYL 326
            .||.|.|:|:.|...|......:|.||..|.:::|...|:||::|::::||.|.:.|.:|.|..:
plant   396 ASGKVTNMITTDANALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFGSLILFLLIPFQTLI 460

  Fly   327 GTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGF 391
            ..:...:..:..:.||.|:.::.||::::.::|.||||:.||..:...|.:|::..|:.|.:..|
plant   461 VRKMRKLTKEGLQWTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAF 525

  Fly   392 DFARRIVLSRVAIFLSLVG---YVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLT 453
            :   ..:|:...:.::||.   ||:||...||..||...:.:.||.:.:|. :|:.|.|......
plant   526 N---SFILNSTPVVVTLVSFGVYVLLGGDLTPARAFTSLSLFAVLRSPLST-LPNLISQAVNANV 586

  Fly   454 SIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLS 518
            |::|:|:.:.|||     :....:....||.|            ||||::....||..:...|||
plant   587 SLQRIEELLLSEE-----RILAQNPPLQPGAP------------AISIKNGYFSWDSKTSKPTLS 634

  Fly   519 GINLEIKPGSVVAVIGLTGSGKSSLIQAILGELK-ANSGQLQVNGSLSYTSQESWLFSGTVRQNI 582
            .|||||..||:||::|.||.||:|||.|:||||. |.:..:.:.||::|..|.||:|:.|:|:||
plant   635 DINLEIPVGSLVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENI 699

  Fly   583 LFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLL 647
            |||...:|:||...:...||:.|.||.|.||.|.:||||..:|||||.|:|:||:||..:.||:.
plant   700 LFGSDFESERYWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIF 764

  Fly   648 DDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKT 712
            |||.||:||.||..:||.||:..|:|.|.||||:|..|||.:|:|::::.|.||..|::..|.|:
plant   765 DDPFSALDAHVAHQVFDSCVKHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKS 829

  Fly   713 G-----LITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGK------EH 766
            |     |:...|.:..|.:..|.::....|..       |...:.||:::|....||      ..
plant   830 GTLFKKLMENAGKMDATQEVNTNDENISKLGP-------TVTIDVSERSLGSIQQGKWGRSMLVK 887

  Fly   767 VERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEME 831
            .|.:|:|.||..:..:|.:|.|||...:::|...:..:|.......:|:.|. .:||...:
plant   888 QEERETGIISWDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIWT-DQSTPKSY---- 947

  Fly   832 DMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSI 896
               |....:..|.|:....|.:..::||.|.:.:..|:.|||:.:.|.:.||.|.||..|..|.:
plant   948 ---SPGFYIVVYALLGFGQVAVTFTNSFWLISSSLHAAKRLHDAMLNSILRAPMLFFETNPTGRV 1009

  Fly   897 LNRFTKDMSQVDEVLPVVLVDVMQIALW-LAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKT 960
            :|||:||:..:|..: ..|:::....|| |.....:|..|:.:.|...:.|.::||.....|..|
plant  1010 INRFSKDIGDIDRNV-ANLMNMFMNQLWQLLSTFALIGIVSTISLWAIMPLLILFYATYIYYQST 1073

  Fly   961 SRDLKRVEAINRSPVYSHLAASLNGLTTIRALDA----QRVLEKEFDS---YQDAHSSAFFMYIS 1018
            ||:::|::::.|||:|:....:||||::|||..|    .::..|..|:   :..|.:|:......
plant  1074 SREVRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTLASTSSNRWLTI 1138

  Fly  1019 TSQAFGYCMNCICVIYISIITLSFFAFPPGN-------GADVGLVITQAMGLIDMVQWGVRQTAE 1076
            .|::.|..|     |:   :|.:|.....||       .:.:||:::..:.:..::...:||.::
plant  1139 RSESLGGVM-----IW---LTATFAVLRYGNAENQAVFASTMGLLLSYTLNITTLLSGVLRQASK 1195

  Fly  1077 LENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSF 1141
            .||::.:||||..|..: |.......::.:|...||.:|.|.|::::|||.|....  ||..|||
plant  1196 AENSLNSVERVGNYIDL-PSEATAIIENNRPVSGWPSRGSIQFEDVHLRYRPGLPP--VLHGLSF 1257

  Fly  1142 VIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLF 1205
            .:.|.||||:||||||||||::|||:|: ....|.:|||..|..:.||.||||.:|||||.||||
plant  1258 FVYPSEKVGVVGRTGAGKSSMLNALYRIVELEKGRILIDDYDVAKFGLTDLRRVLSIIPQSPVLF 1322

  Fly  1206 SGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAIL 1270
            |||:|:|:|||.|::|..||..||...:|:|:...|.||.:::||||.|||||||||:.||||:|
plant  1323 SGTVRFNIDPFSEHNDADLWEALERAHIKDVIDRNPFGLDAEVSEGGENFSVGQRQLLSLARALL 1387

  Fly  1271 RENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGS 1335
            |.::||.:|||||:||.:||.|||.|||.:|:.||:|.|||||:||||.||::|:.:|:|:|:.|
plant  1388 RRSKILFLDEATASVDVRTDSLIQRTIREEFKSCTMLIIAHRLNTIIDCDKILVLSSGQVLEYDS 1452

  Fly  1336 PYELMTKSDSKVFHNLVNQSG 1356
            |.||::: |:..|..:|:.:|
plant  1453 PQELLSR-DTSAFFKMVHSTG 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	455/1292 (35%)
		ABC_membrane	171..437	CDD:294371	80/272 (29%)
		ABCC_MRP_domain1	499..699	CDD:213217	100/200 (50%)
		ABC_membrane	799..1045	CDD:294371	67/253 (26%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	125/221 (57%)
ABCC11	NP_001319112.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720