DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC12

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1328	Identity:	462/1328 - (34%)
Similarity:	747/1328 - (56%)	Gaps:	96/1328 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 EKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELK 147
            |.:.||.   .::..|.:.|.:..|:.:.||||.:...|:::..:..:::.|..|....|..|.:
plant   224 EHICPER---HASIFSRIYFGWITPLMQLGYRKPITEKDVWQLDKWDQTETLIKRFQRCWTEESR 285

  Fly   148 NDGRSPSLVRALLRVFGWQLGFPGLAIF-VVELGLRTLQ---PIFLVKLISYFSGEPDAANAGFY 208
            ..  .|.|:|||....|.:....|  || |..:|....|   |:.|..|:.... |.|.|..|:.
plant   286 RP--KPWLLRALNNSLGGRFWLAG--IFKVTRIGNDLSQFVGPVILSHLLRSMQ-EGDPAWVGYV 345

  Fly   209 YAVAQIVISALTVMILTPTTF--GIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLIS 271
            ||.  |:...:|:.:|....:  .:..|.|::|..:.:.||.|:||||..|..:..||.|.|:|:
plant   346 YAF--IIFVGVTLGVLCEAQYFQNVWRVGFRLRSTLVAAIFHKSLRLTHEARKNFASGKVTNMIT 408

  Fly   272 NDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336
            .|...|......:|.||..|.:::|...|:||::|::::||.|.:.|.:|:|..:.::...:..:
plant   409 TDANALQQISQQLHGLWSAPFRIIVSMILLYQQLGVASLFGSLILFLLIPLQTLIISKMRKLTKE 473

  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR 401
            ..:.||.|:.:.|||:|::..:|.||||:.||..:...|.:|::..|:.|.:..|:   ..:|:.
plant   474 GLQWTDKRVGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFN---SFILNS 535

  Fly   402 VAIFLSLVG---YVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQ 463
            :.:.:::|.   :|:||...||..||...:.:.||...::: :|:.:.|......|::|:|:.:.
plant   536 IPVVVTVVSFGVFVLLGGDLTPARAFTSLSLFAVLRFPLNM-LPNLLSQVVNANVSLQRIEELLL 599

  Fly   464 SEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGS 528
            |||     :....:....||.|            ||||::....||..:...|||.|||||..|:
plant   600 SEE-----RILAQNPPLQPGTP------------AISIKNGYFSWDSKTTKPTLSDINLEIPVGT 647

  Fly   529 VVAVIGLTGSGKSSLIQAILGELK-ANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQR 592
            :||::|.||.||:|||.|:||||. |.:..:.:.||::|..|.||:|:.|||:|||||...:|:|
plant   648 LVAIVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWIFNATVRENILFGSDFESER 712

  Fly   593 YEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDAS 657
            |...:...||:.|.||||.||.|.:||||..:|||||.|:|:||:||..:.:|:.||||||:||.
plant   713 YWRAIDATALQHDLDLLPGRDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAH 777

  Fly   658 VARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTG-----LITG 717
            ||..:||.|::..|||.|.||||:|..|||.:|:|::::.|.||..|.:..|.|:|     |:..
plant   778 VAHQVFDSCMKDELRGKTRVLVTNQLHFLPLMDKIILVSEGMIKEEGTFVELSKSGILFKKLMEN 842

  Fly   718 LGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEH------VERQESGGIS 776
            .|.:..|.:..|.::..|.|..       |...:.||:.:|.:..||..      .|.:|:|.||
plant   843 AGKMDATQEVNTNDENILKLGP-------TVTVDVSERNLGSTKQGKRRRSVLIKQEERETGIIS 900

  Fly   777 LALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVY 841
            ..:..:|.:|.|||...:::|:..:..:|.......:|:.|. .:||:..:       |....:.
plant   901 WNVLMRYKEAVGGLWVVMILLACYLATEVLRVSSSTWLSIWT-DQSTSKNY-------SPGFYIV 957

  Fly   842 KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQ 906
            .|.|:....|.:..::||.|...:..|:.|||:.:.:.:.||.|.||..|..|.::|||:||:..
plant   958 VYALLGFGQVAVTFTNSFWLITSSLHAARRLHDAMLSSILRAPMLFFHTNPTGRVINRFSKDIGD 1022

  Fly   907 VDEVLPVVLVDVMQIALW-LAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAI 970
            :|..: ..|:::....|| |.....:|..|:.:.|...:.|.::||.....|..|||:::|::::
plant  1023 IDRNV-ANLMNMFMNQLWQLLSTFALIGTVSTISLWAIMPLLILFYAAYLYYQSTSREVRRLDSV 1086

  Fly   971 NRSPVYSHLAASLNGLTTIRALDA----QRVLEKEFDS---YQDAHSSAFFMYISTSQAFGYCMN 1028
            .|||:|:....:||||::|||..|    .::..|..|:   :..|::|:........:..|..|
plant  1087 TRSPIYAQFGEALNGLSSIRAYKAYDRMAKINGKSMDNNIRFTLANTSSNRWLTIRLETLGGVM- 1150

  Fly  1029 CICVIYISIITLSFFAFPPGN-------GADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVER 1086
                |:   :|.:|.....||       .:.:||:::..:.:..::...:||.:..||::.:|||
plant  1151 ----IW---LTATFAVLQNGNTNNQAGFASTMGLLLSYTLNITSLLSGVLRQASRAENSLNSVER 1208

  Fly  1087 VVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGI 1151
            |..|..: |....:..::.:|...||..|.|.|::::|||.|....  ||..|:|.:.|.||||:
plant  1209 VGNYIDL-PSEATDIIENNRPVCGWPSGGSIKFEDVHLRYRPGLPP--VLHGLTFFVSPSEKVGV 1270

  Fly  1152 VGRTGAGKSSLINALFRLSYTD-GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDP 1215
            ||||||||||::|||||:...: |.::||..|..:.||.|:||.:|||||.|||||||:|:|:||
plant  1271 VGRTGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVLSIIPQSPVLFSGTVRFNIDP 1335

  Fly  1216 FDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1280
            |.|::|..||..|....:|:|:|..|.||.:::.|||.|||||||||:.||||:||.::|||:||
plant  1336 FSEHNDAGLWEALHRAHIKDVISRNPFGLDAEVCEGGENFSVGQRQLLSLARALLRRSKILVLDE 1400

  Fly  1281 ATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS 1345
            |||:||.:||.|||.|||.:|:.||:|.|||||:||||.||::|:.:|:|:|:.||.||::: |:
plant  1401 ATASVDVRTDSLIQRTIREEFKSCTMLVIAHRLNTIIDCDKILVLSSGQVLEYDSPQELLSR-DT 1464

  Fly  1346 KVFHNLVNQSGRASYEGLLKIAQETFES 1373
            ..|..:|:.:|.|:.:.|..:..|..|:
plant  1465 SAFFRMVHSTGPANAQYLSNLVFERREN 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	451/1290 (35%)
		ABC_membrane	171..437	CDD:294371	81/274 (30%)
		ABCC_MRP_domain1	499..699	CDD:213217	101/200 (51%)
		ABC_membrane	799..1045	CDD:294371	65/253 (26%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	123/221 (56%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720