DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and Abcb11

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_113948.1 Gene:Abcb11 / 83569 RGDID:619930 Length:1321 Species:Rattus norvegicus


Alignment Length:1311 Identity:309/1311 - (23%)
Similarity:543/1311 - (41%) Gaps:301/1311 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 AGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRV----------AMGSMIFRKALRLTKGALG 259
            :|.|..|      .:||:||.         .|::|:          .|..:.||:.:|:..|...
  Rat   142 SGIYAGV------GMTVLILG---------YFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFD 191

  Fly   260 DTTSGHVVNLISNDIPRLDS--APYTVHYL-----------------WVGPLQVLVITYLMYQEI 305
            .|:.|.:.:..::||.:::.  |....|:|                 |...|.:|.::.|    |
  Rat   192 CTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPL----I 252

  Fly   306 GI-SAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQ 369
            || :||.|:..            .:.:.::|||..:..:   :.:|::|:|:.:..:..|     
  Rat   253 GIGAAVIGLSI------------AKFTELELKAYAKAGS---IADEVLSSIRTVAAFGGE----- 297

  Fly   370 MVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAF---------- 424
                  .||:.     :|.:...||:|..:.:..:.....||:.....|...:||          
  Rat   298 ------NKEVE-----RYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDE 351

  Fly   425 -------MITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVP 482
                   ::..:..|:||||:|...|:.::.  |.|.........|:.:       ..|..|.:.
  Rat   352 EEYTPGTLVQIFLCVILAAMNIGHASSCLEI--FSTGCSAATNIFQTID-------RQPVIDCMS 407

  Fly   483 GNPPSNNNEADLLKSAISIRDLKAKWDPNSPDY-TLSGINLEIKPGSVVAVIGLTGSGKSSLIQA 546
            |    :..:.|.:|..|...::...: |:.||. .|..:::.||||...|::|.:|:|||:.:|.
  Rat   408 G----DGYKLDRIKGEIEFHNVTFHY-PSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQL 467

  Fly   547 ILGELKANSGQLQVNG-------------SLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVK 598
            |........|.:.::|             .:....||..|||.|:.:||.||:  :....|::|:
  Rat   468 IQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGR--EDATMEDIVQ 530

  Fly   599 --KCALERDFDL-LPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVD-ASVA 659
              |.|...:|.: ||.:.:|:|||.|..:|||||.|:::||::.|...|.|||...||:| .|.|
  Rat   531 AAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEA 595

  Fly   660 R--HLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL------------ 710
            |  ...::...||    |::.|.|:...:...|.|:...:|.....|.:|.||            
  Rat   596 RVQEALNKIQHGH----TIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTL 656

  Fly   711 ---------KTGLI----TGLGSLSKT-------------DKAKTEEQEPLNLNSP-----DNKN 744
                     :|.::    |..|:|.:|             .:.:::.|..|..:.|     |:|:
  Rat   657 QSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKS 721

  Fly   745 EVTPIKENSEQTVGGSSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQV--AV 807
            .....|:|...           ||..|...:...|  ||     .:..:..:|..|:.|.:  ||
  Rat   722 SYKDSKDNDVL-----------VEEVEPAPVRRIL--KY-----NIPEWHYILVGSLSAAINGAV 768

  Fly   808 TGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLL-FNIAKKASI- 870
            | ..|.|.:     |...|...:.|.|.:..:::...|..::...:::.:.||. :..||...: 
  Rat   769 T-PIYSLLF-----SQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELL 827

  Fly   871 --RLHNTIFNRVTRADMHFFS--INKHGSILNRFTKDMSQV-----DEVLPVV-----LVDVMQI 921
              ||....|..:...|:.:|.  .|..|.:..|...|.|||     .:|..:|     ::..:.|
  Rat   828 TKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLI 892

  Fly   922 AL---WLAGIIIVIANVNPLL----LVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHL 979
            |.   |...:||.|  ..|.|    .|.|.||:..          .|:|.:.:|...:.     .
  Rat   893 AFFFSWKLSLIITI--FFPFLALSGAVQTKMLTGF----------ASQDKQALEKAGQI-----T 940

  Fly   980 AASLNGLTTIRALDAQRVLEKEFD-SYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFF 1043
            :.:|:.:.|:..:..:....|.|: ..|.::.:|    :..:..:|.|                |
  Rat   941 SEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTA----VRKANIYGLC----------------F 985

  Fly  1044 AFPPG-----NGADVG----LVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGML 1099
            ||..|     |.|...    |:..:.:|...:    .|..:.:..:.|||.|...|.....:..:
  Rat   986 AFSQGIAFLANSAAYRYGGYLIAYEGLGFSHV----FRVVSSVALSATAVGRTFSYTPSYAKAKI 1046

  Fly  1100 EAPD-----DKKPP--------KTWPE-QGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVG 1150
            .|..     |:|||        :.|.. ||:|.|.:....| |:.....||..||..:.|.:.:.
  Rat  1047 SAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTY-PSRPDIQVLNGLSVSVNPGQTLA 1110

  Fly  1151 IVGRTGAGKSSLINALFRLSYTD-GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNL- 1213
            .||.:|.|||:.|..|.|....| |:|:||..|::::.:..||..|.|:.||||||..::..|: 
  Rat  1111 FVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIK 1175

  Fly  1214 --DPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRIL 1276
              |...|.|.|:.....::.:|.:.|..||:...:.:...|:..|.|::|.:.:||||:|:.:||
  Rat  1176 YGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKIL 1240

  Fly  1277 VMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMT 1341
            ::||||:.:|.:::..:|..:.......|.:.|||||.||.:||.:.|:..|.|:|.|:..:||.
  Rat  1241 LLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMA 1305

  Fly  1342 KSDSKVFHNLV 1352
            :..:  ::.||
  Rat  1306 QKGA--YYKLV 1314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 307/1300 (24%)
ABC_membrane 171..437 CDD:294371 52/278 (19%)
ABCC_MRP_domain1 499..699 CDD:213217 67/219 (31%)
ABC_membrane 799..1045 CDD:294371 54/271 (20%)
ABCC_MRP_domain2 1115..1336 CDD:213211 76/224 (34%)
Abcb11NP_113948.1 PTZ00265 150..1314 CDD:240339 304/1295 (23%)
Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385 651..674 1/22 (5%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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