DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC10

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1317	Identity:	400/1317 - (30%)
Similarity:	664/1317 - (50%)	Gaps:	136/1317 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCAS-WERELKNDGR---- 151
            |::...|:|.||:...:.::|..|.|:..|:....:|::::     .|.| :|..|....|
plant   208 AKAGLFSTLSFWWLNSLIKRGNVKDLEEEDIPELRKEERAE-----TCYSLFEENLIEQKRRLGS 267

  Fly   152 --SPSLVRALLRVFGWQL----GFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANAGFYY- 209
              .||:::..:.....:|    .|..:.|..|..|     |:.|...|....|     ||.|.|
plant   268 SCQPSILKVTVLCVWRELLTSGFFAFMKIVAVSAG-----PLLLNAFILVAEG-----NASFRYE 322

  Fly   210 --AVAQIVISALTVMILTPTT--FGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLI 270
              .:|.::..:..:..|:...  |....|..::|..:.:.|.:|.|||...:....:...::|..
plant   323 GLVLAVLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYA 387

  Fly   271 SNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQL 335
            :.|..|:...||..|.||....|:|:...:::..:|::....:..::|.:.....:....:..|.
plant   388 TVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQS 452

  Fly   336 KAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLS 400
            :.....|.|::..||.:..::|||:||||..|::::...|..|:.:::..|..:.::
plant   453 ELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYN-------- 509

  Fly   401 RVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIY---------------VPSAIIQTAQ 450
             ..:|.|       ..||.....|....:.::.|.|.:::               :|..|..|.|
plant   510 -AVLFWS-------SPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPDVIGVTIQ 566

  Fly   451 FLTSIRRVEQFMQSEELGSSD-----KSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDP 510
            ...:..|:..|:::.||...:     :|||             |..|.::|||....:.|....|
plant   567 AKVAFSRIATFLEAPELQGGERRRKQRSEG-------------NQNAIIIKSASFSWEEKGSTKP 618

  Fly   511 NSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFS 575
            |     |..::||:|.|..|||.|..|||||:|:.|||||....||.:...|:::|.||.:|:.:
plant   619 N-----LRNVSLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQT 678

  Fly   576 GTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYR 640
            ||:|.|||||..||..||.|.::|.:|::|.:|||..|.|.:||||..||||||.||.|||::|:
plant   679 GTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQ 743

  Fly   641 KASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGD 705
            .|.|||||||.|||||..|..||.:.|...|.|..|:|||||..|||..|.::::::|:|.....
plant   744 DADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADT 808

  Fly   706 YESLLKTG-----LITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKE------NSEQTVGG 759
            |:.||...     |:......:.:::....|            |...|:||      :..:.:..
plant   809 YQELLARSRDFQDLVNAHRETAGSERVVAVE------------NPTKPVKEINRVISSQSKVLKP 861

  Fly   760 SSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTA 824
            |...|:  |.:|.|...|..|.:|.....|.:.|.:    :.||||....|......|:     |
plant   862 SRLIKQ--EEREKGDTGLRPYIQYMNQNKGYIFFFI----ASLAQVTFAVGQILQNSWM-----A 915

  Fly   825 AGHGEMEDMESKSMDVYK----YTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADM 885
            |      ::::..:...|    |.||.:.||:..:..|..:..:..|:|..|.:.:.|.:.||.|
plant   916 A------NVDNPQVSTLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPM 974

  Fly   886 HFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIF 950
            .|:.....|.||:|.:.|:|.||..:|..|:.|:..::.....:.|:|.|...:|..::.:..:.
plant   975 SFYDSTPLGRILSRVSSDLSIVDLDVPFGLIFVVASSVNTGCSLGVLAIVTWQVLFVSVPMVYLA 1039

  Fly   951 YHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFM 1015
            :.|:..|.:|:::|.|:....||.|.:|||.|:.|..||||.|.:....|:..:..|.::|.||.
plant  1040 FRLQKYYFQTAKELMRINGTTRSYVANHLAESVAGAITIRAFDEEERFFKKSLTLIDTNASPFFH 1104

  Fly  1016 YISTSQAFGYCMNCICVIYISIITLSFFAFPPG--NGADVGLVITQAMGLIDMVQWGVRQTAELE 1078
            ..:.::.....:..:..|.::.........|.|  :...:|:.::..:.|...:.:.|:....|.
plant  1105 SFAANEWLIQRLETVSAIVLASTAFCMILLPTGTFSSGFIGMALSYGLSLNMGLVYSVQNQCYLA 1169

  Fly  1079 NTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
            |.:.:|||:.:|..:.||.. |..::.:||..||..|.:...:|.:||  ..::..|||.:|...
plant  1170 NWIISVERLNQYTHLTPEAP-EVIEETRPPVNWPVTGRVEISDLQIRY--RRESPLVLKGISCTF 1231

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            :...|:|||||||:||::||:||||| ....|.:::|..|..::|:||||.:..||||:|.||:|
plant  1232 EGGHKIGIVGRTGSGKTTLISALFRLVEPVGGKIVVDGVDISKIGVHDLRSRFGIIPQDPTLFNG 1296

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRE 1272
            |:|:||||..::||.::|..|.:.:|||||.:..:||.|.:.|.|:|:|:|||||.||.||:||.
plant  1297 TVRFNLDPLCQHSDAEIWEVLGKCQLKEVVQEKENGLDSLVVEDGSNWSMGQRQLFCLGRAVLRR 1361

  Fly  1273 NRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPY 1337
            :|:||:|||||::|..||.::|.|||.:|.||||:|:|||:.|::|...|:.:..||:||:..|.
plant  1362 SRVLVLDEATASIDNATDLILQKTIRREFADCTVITVAHRIPTVMDCTMVLSISDGRIVEYDEPM 1426

  Fly  1338 ELMTKSDSKVFHNLVNQ 1354
            :|| |.::.:|..||.:
plant  1427 KLM-KDENSLFGKLVKE 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	396/1304 (30%)
		ABC_membrane	171..437	CDD:294371	55/270 (20%)
		ABCC_MRP_domain1	499..699	CDD:213217	96/199 (48%)
		ABC_membrane	799..1045	CDD:294371	62/249 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	105/221 (48%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	397/1310 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720