DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC7

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_187917.3	Gene:	ABCC7 / 820498	AraportID:	AT3G13100	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1355	Identity:	425/1355 - (31%)
Similarity:	685/1355 - (50%)	Gaps:	117/1355 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VCRKCFELGHQTEN----CKQKLTVNSENNSAQN------EKEKVLPENPRARSNFISSLCFWYT 105
            :|..|.:...|.|.    .::.|...:|:::|.:      |.::|:  .|.:.:.|:|.:.|.:.
plant   184 LCYSCLQKQGQGERINLLLEEPLLNGAESSAATSVQLDKAEDDEVV--TPFSNAGFLSHVSFSWM 246

  Fly   106 IPIFRKGYRKTLDSTDLYRPLEEQKSD----ILGNRLCASWERELKNDGR----SPSLVRALLRV 162
            .|:...|..|.:||.|:.:.....:::    |..::|  .|:     ||.    :..|::||...
plant   247 SPLIVLGNEKIIDSEDVPQVDNSDRAEKLFWIFRSKL--EWD-----DGERRITTYKLIKALFFS 304

  Fly   163 FGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPT 227
            ....:....|..||..:.. .:.|..:...:.|.:|:...:|.|........|...:........
plant   305 VWRDILLSTLFAFVYTVSC-YVAPYLMDTFVQYLNGQRQYSNQGVVLVTTFFVAKLVECQARRNW 368

  Fly   228 TFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPL 292
            .|.:......||..:.|||:.|.|.|...:....|||.::||::.|..|:.:..:.:|..|:..|
plant   369 YFRLQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEIINLMTVDAERISAFSWYMHDPWILVL 433

  Fly   293 QVLVITYLMYQEIGIS--AVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAI 355
            |:.:...::|:.:|:.  |.|...|:::...|.  |.......|....|..|||::..:|.:..:
plant   434 QISLALLILYRSLGLGSIAAFAATFLVMLGNIP--LAKLEEKFQGNLMESKDNRMKKTSEALLNM 496

  Fly   356 QVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLV--GYVILGKVF 418
            ::||:..||..|...:...|..|...:::..|...   |...||.....|:|..  |..:|.|:
plant   497 RILKLQGWEMKFLHKILDLRGIEAGWLKKFVYNSA---AISSVLWAAPSFVSATAFGACMLLKI- 557

  Fly   419 TP-EIAFMITAYYNVLLAAMSIY-VPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTV 481
             | |...:|.|.....:....|| :|..|....|...|:.|:..|:..::|........||
plant   558 -PLESGKIIAALATFRILQTPIYKLPDTISMIVQTKVSLDRIATFLCLDDLQQDGMERLPS---- 617

  Fly   482 PGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQA 546
                .|:..:.::...|.|       ||.:||..||..|..:|..|..:|:.|..|||||||:.:
plant   618 ----GSSKMDVEVSNGAFS-------WDDSSPIPTLKDIRFKIPHGMNIAICGTVGSGKSSLLSS 671

  Fly   547 ILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPL 611
            ||||:...||.|:|.|..:|.:|..|:.||.|.:|||||:||..:.|:.|::.|:|.:|.::.|.
plant   672 ILGEVPKISGNLKVCGRKAYIAQSPWIQSGKVEENILFGKPMQREWYQRVLEACSLNKDLEVFPF 736

  Fly   612 RDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTV 676
            ||.|::||||..||||||.||.:||::|:.|.|||.|||.|||||....|||.:.:.|.||..||
plant   737 RDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTV 801

  Fly   677 VLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGL----ITG-----LGSLSKTDKAKTEEQ 732
            :.||||.:|||..|.|:::.:|:|...|.|..:|::|.    :.|     |.::...:|.....|
plant   802 IYVTHQLEFLPEADLILVMKDGRITQAGKYNEILESGTDFMELVGAHTDALAAVDSYEKGSASAQ 866

  Fly   733 EPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGISLALYRKYFQA--GGGLVAFLV 795
                 ::...:::|:..:|..|:.:..........|.:|.|.:...:|:||.:.  ||.||..::
plant   867 -----STTSKESKVSNDEEKQEEDLPSPKGQLVQEEEREKGKVGFTVYQKYMKLAYGGALVPIIL 926

  Fly   796 MLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFL 860
            ::  .:|.||...|.:|::. ||...|.     :::.:.|.|      |||::. |.:..:|||.
plant   927 VV--QILFQVLNIGSNYWMA-WVTPVSK-----DVKPLVSGS------TLILVY-VFLATASSFC 976

  Fly   861 LFNIAK-------KASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDV 918
            :...|.       |.:..|.|.:..|:.||.|.||.....|.||||.:.|.|.||..||....::
plant   977 ILVRAMLSAMTGFKIATELFNQMHFRIFRASMSFFDATPIGRILNRASTDQSAVDLRLPSQFSNL 1041

  Fly   919 MQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASL 983
            ...|:.:.|||.|:..|...:|:..:.:.......|..|:..:|:|.|:..|:|||:..|.:.:|
plant  1042 AIAAVNILGIIGVMGQVAWQVLIVFIPVIAACTWYRQYYISAARELARLSGISRSPLVQHFSETL 1106

  Fly   984 NGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPG 1048
            :|:||||:.|.:.....:.....|.:|...|..||..:...:.::.:..:..::..:...:.|.|
plant  1107 SGITTIRSFDQEPRFRTDIMRLNDCYSRLRFHAISAMEWLCFRLDLLSTVAFALSLVILVSVPEG 1171

  Fly  1049 --NGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESI--EPEGMLEAPDDKKPPK 1109
              |.:..||.:|.|:.|..:....:....:|||.|.:|||:::|..|  ||..::|:   .:|.|
plant  1172 VINPSFAGLAVTYALNLNSLQATLIWTLCDLENKMISVERMLQYIDIPSEPSLVIES---TRPEK 1233

  Fly  1110 TWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTD 1173
            :||.:|||....|.:||.|:...  ||:.|:...:...|.|||||||.|||:||..|||: ....
plant  1234 SWPCRGEITICNLQVRYGPHLPM--VLRGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAA 1296

  Fly  1174 GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCL------EEVK 1232
            |.:.||..:...:||||||.::|||||||.:|.||:|.||||.:||:|:::|..|      :|::
plant  1297 GEIRIDGINILTIGLHDLRSRLSIIPQEPTMFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIR 1361

  Fly  1233 LKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATI 1297
            .||:..|.|      :||.|.|:||||||||||.|.:|:.:::|::|||||:||..||.|||.|:
plant  1362 KKELKLDSP------VSENGQNWSVGQRQLVCLGRVLLKRSKVLILDEATASVDTATDTLIQETL 1420

  Fly  1298 RSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            |..|..|||:|||||:.::||||.|:::|.|.:.|..||..|: :..|..|..||
plant  1421 RQHFSGCTVITIAHRISSVIDSDMVLLLDQGLIEEHDSPARLL-EDKSSSFSKLV 1474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	412/1296 (32%)
		ABC_membrane	171..437	CDD:294371	62/270 (23%)
		ABCC_MRP_domain1	499..699	CDD:213217	94/199 (47%)
		ABC_membrane	799..1045	CDD:294371	67/252 (27%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	108/227 (48%)
ABCC7	NP_187917.3	PLN03232	34..1474	CDD:215640	423/1353 (31%)
		ABC_membrane	309..578	CDD:294371	62/276 (22%)
		ABCC_MRP_domain1	624..824	CDD:213217	95/206 (46%)
		ABC_membrane	925..1199	CDD:294371	75/288 (26%)
		ABCC_MRP_domain2	1239..1459	CDD:213211	108/227 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720