DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_182301.1	Gene:	ABCC4 / 819392	AraportID:	AT2G47800	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1340	Identity:	435/1340 - (32%)
Similarity:	710/1340 - (52%)	Gaps:	114/1340 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 VNSENNSAQNEKEKVLPENPRARSNFIS----SLCFW-YTIPIFRKGYRK--TLDSTDLYRPLEE 128
            |.:|.||.....:.|..|.....|.:.|    |..|| :..|:..|||:.  ||:......|  |
plant   227 VTAETNSPTKPSDAVSVEKSDNVSLYASASVFSKTFWLWMNPLLSKGYKSPLTLEQVPTLSP--E 289

  Fly   129 QKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLI 193
            .|::.|.....:||.:..:|.  |..:...|||.|..::.|..: :.:|.||:..:.|:.:...:
plant   290 HKAERLALLFESSWPKPSENS--SHPIRTTLLRCFWKEILFTAI-LAIVRLGVMYVGPVLIQSFV 351

  Fly   194 SYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGAL 258
            .:.||:..:...|:|..:..:|...:.|:......|....:...:|..:.:.:::|.|:||..|.
plant   352 DFTSGKRSSPWQGYYLVLILLVAKFVEVLTTHQFNFDSQKLGMLIRSTLITALYKKGLKLTGSAR 416

  Fly   259 GDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIG---ISAVFGVLFMLLFM 320
            .:...|.:||.::.|..:|......:|.:|:.||||.|...|:|..:|   |:||.|:..:.:|
plant   417 QNHGVGQIVNYMAVDAQQLSDMMLQLHAIWLMPLQVTVALVLLYGSLGASVITAVIGLTGVFVF- 480

  Fly   321 PIQMYLGT-RTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQ 384
               :.||| |.:..|.......|:|::..||:::.::|:|..|||..|.:.:...|:.|...:.:
plant   481 ---ILLGTQRNNGYQFSLMGNRDSRMKATNEMLNYMRVIKFQAWENHFNKRILKFRDMEFGWLSK 542

  Fly   385 GQY-IRGFDFARRIVLSRVAIFLSLVGY---VILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAI 445
            ..| |.|    ..|||....:.:|.:.:   :.||........|..|..:.:|...:..: |.::
plant   543 FLYSIAG----NIIVLWSTPVLISALTFATALALGVKLDAGTVFTTTTIFKILQEPIRTF-PQSM 602

  Fly   446 IQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDP 510
            |..:|.:.|:.|::.:|.|:||         |:|.|......:.|      :|:.:||....||.
plant   603 ISLSQAMISLGRLDSYMMSKEL---------SEDAVERALGCDGN------TAVEVRDGSFSWDD 652

  Fly   511 NSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFS 575
            ...:..||.||.::|.|.:.|::|..|||||||:.::|||:...|||::|.||..|.:|.||:.:
plant   653 EDNEPALSDINFKVKKGELTAIVGTVGSGKSSLLASVLGEMHRISGQVRVCGSTGYVAQTSWIEN 717

  Fly   576 GTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYR 640
            |||:.|||||.||..::|.:|:..|:||:|..::...|.|.:||||..||||||.||.|||:||:
plant   718 GTVQDNILFGLPMVREKYNKVLNVCSLEKDLQMMEFGDKTEIGERGINLSGGQKQRIQLARAVYQ 782

  Fly   641 KASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGD 705
            :..:|||||..|||||.....:|.:||||.|:|.||:|||||..||.:||.|:::.:|:|...|.
plant   783 ECDVYLLDDVFSAVDAHTGSDIFKKCVRGALKGKTVLLVTHQVDFLHNVDCILVMRDGKIVESGK 847

  Fly   706 YESLLKTGLITGLGSLSKTDKAKTEEQE-----------PLNLNSPDNKNEVTPIK--------- 750
            |:.|:.:||  ..|.|....:...|..|           |....||...:..|.::
plant   848 YDELVSSGL--DFGELVAAHETSMELVEAGADSAAVATSPRTPTSPHASSPRTSMESPHLSDLND 910

  Fly   751 ENSEQTVG------GSSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTG 809
            |:.:..:|      ||...||  |.:|:|.:||.:|::|.....|....:::|..|:..|.::..
plant   911 EHIKSFLGSHIVEDGSKLIKE--EERETGQVSLGVYKQYCTEAYGWWGIVLVLFFSLTWQGSLMA 973

  Fly   810 GDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHN 874
            .||:|.|     .|:|.:....|   .|:.:..|.:|.::|:::....|:.:.::..|.:.....
plant   974 SDYWLAY-----ETSAKNAISFD---ASVFILGYVIIALVSIVLVSIRSYYVTHLGLKTAQIFFR 1030

  Fly   875 TIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANV---N 936
            .|.|.:..|.|.||.....|.||:|.:.|.:.||.::|.:|..|:.:...|..|.||....   .
plant  1031 QILNSILHAPMSFFDTTPSGRILSRASTDQTNVDILIPFMLGLVVSMYTTLLSIFIVTCQYAWPT 1095

  Fly   937 PLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKE 1001
            ...::|...|::.:   ||.||.:||:|.|:::|.::|:..|.:.|:.|:.|||:...|.:..:|
plant  1096 AFFVIPLGWLNIWY---RNYYLASSRELTRMDSITKAPIIHHFSESIAGVMTIRSFRKQELFRQE 1157

  Fly  1002 -----FDSYQ-DAHSSAFFMYISTSQAFGYCMNCI-----CVIYISIITLSFFAFPPGNGADVGL 1055
                 .|:.: |.|::      .:::..|:.:..:     |:..:.::.|......|.|   |||
plant  1158 NVKRVNDNLRMDFHNN------GSNEWLGFRLELVGSWVLCISALFMVLLPSNVIRPEN---VGL 1213

  Fly  1056 VITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFK 1120
            .::..:.|..::.:.:..:..:||.|.:|||:.::..|..|...|. .:..||..||..|.:..:
plant  1214 SLSYGLSLNSVLFFAIYMSCFVENKMVSVERIKQFTDIPSESEWER-KETLPPSNWPFHGNVHLE 1277

  Fly  1121 ELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTR 1184
            :|.:||.||...  |||.::..|:..||||:|||||:|||:||..|||| ..:.|.::||..|..
plant  1278 DLKVRYRPNTPL--VLKGITLDIKGGEKVGVVGRTGSGKSTLIQVLFRLVEPSGGKIIIDGIDIS 1340

  Fly  1185 QMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKIS 1249
            .:||||||.:..|||||||||.||:|.|:||.::||||::|..||..:||:||:..|:.|.|.:.
plant  1341 TLGLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEQYSDEEIWKSLERCQLKDVVATKPEKLDSLVV 1405

  Fly  1250 EGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLH 1314
            :.|.|:|||||||:||.|.:|:.:|:|.:|||||:||.|||.:||..||..|..||:::||||:.
plant  1406 DNGENWSVGQRQLLCLGRVMLKRSRLLFLDEATASVDSQTDAVIQKIIREDFASCTIISIAHRIP 1470

  Fly  1315 TIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQ 1354
            |::|.|:|:|:|||:..||.||..|:.:  ..:|..||.:
plant  1471 TVMDGDRVLVIDAGKAKEFDSPARLLER--PSLFAALVQE 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	426/1309 (33%)
		ABC_membrane	171..437	CDD:294371	66/273 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	96/199 (48%)
		ABC_membrane	799..1045	CDD:294371	61/259 (24%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	113/221 (51%)
ABCC4	NP_182301.1	CFTR_protein	255..1502	CDD:273530	424/1304 (33%)
		ABC_membrane	331..595	CDD:294371	66/272 (24%)
		ABCC_MRP_domain1	641..841	CDD:213217	96/199 (48%)
		ABC_membrane	976..1229	CDD:294371	64/272 (24%)
		ABCC_MRP_domain2	1272..1492	CDD:213211	113/221 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720