DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc6

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1355	Identity:	424/1355 - (31%)
Similarity:	681/1355 - (50%)	Gaps:	128/1355 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 NEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWER 144
            :|..|.|...|.|.::|.|...||:...:..|||||.|...||:....|..|:.|.::|...|.|
  Rat   200 SEDSKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRR 264

  Fly   145 EL-----------------------KNDGRSPSLVRALLRVF--GWQLGFPGLAIFVVELGLRTL 184
            ..                       :...|.| |:||:.|||  .:.||...|   |:....|..
  Rat   265 NFSELPGHKGHSGMGTPETEAFLQPERSQRGP-LLRAIWRVFRSTFLLGTLSL---VISDAFRFA 325

  Fly   185 QPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRK 249
            .|..|...:.:......:|..|:..||...:.:.|..:......:.:..:..::|.|:..:::||
  Rat   326 VPKLLSLFLEFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRK 390

  Fly   250 ALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVL 314
            .|.|:.|:...:.:|.||||:|.|:.||..:...::.||:..|.::|....::|.:|.||:..|.
  Rat   391 VLVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVA 455

  Fly   315 FMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEM 379
            ..|..:|:..::..:.|..|.:...:..:|.|:.:.::..::.:|.:.||..|.:.:.|.|.:|:
  Rat   456 VFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQEL 520

  Fly   380 NTIRQGQYIRGFDFARRIVLSRVAIFL-SLVGYVILGKV-----FTPEIAFMITAYYNVLLAAMS 438
            ..::...::    |:..:|..:|:.|| :||.:.:...|     ...|.||:.....::|..|.:
  Rat   521 GALKTSAFL----FSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQA 581

  Fly   439 IYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRD 503
             ::|.::....|...|..|:..|:..||:..:.....||:.:              .|..|||.:
  Rat   582 -FLPFSVHCLVQARVSFDRLAAFLCLEEVDPNGMVLSPSRCS--------------SKDRISIHN 631

  Fly   504 LKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
            ....|...||. .|.||||.:..|.::||:|..|:|||||:.|:||||....|.:.:.||::|..
  Rat   632 GTFAWSQESPP-CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVP 695

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            ||:|:.:.:|.:|:.|.|.:|....:||::.|||..|....|...:|.|||:|..||||||.|:|
  Rat   696 QEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRLS 760

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILA 696
            |||:|||:|::||:||||:|:||.|::.:|.|.:  .|.|:|:|.:||||....||..|||::||
  Rat   761 LARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQADQILVLA 825

  Fly   697 NGQIKALGDYESLL-KTGLITGLGSLSKTDKAKTEEQEPLNLNSPD-----------------NK 743
            ||.|..:|.|:.|| :.|.:.||...::....:.|.:......|.|                 ..
  Rat   826 NGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGGTPTRRPERPRP 890

  Fly   744 NEVTPIKENSEQT----------VGGSSSGKEHVERQESGGISLALYRKYFQA-GGGLVAFLVML 797
            ::..|:|.::.:.          |.|.::|::.|   :.|.:..|.|..|.:| |..|..:.:.|
  Rat   891 SDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDSV---QYGRVKSATYLSYLRAVGTPLCTYTLFL 952

  Fly   798 SSSVLAQVAVTGGDYFLTYWVK------KESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLS 856
              .:..|||.....|:|:.|..      |:..:|..|.:            :.|:..|..|...:
  Rat   953 --FLCQQVASFCQGYWLSLWADDPVVDGKQMHSALRGSI------------FGLLGCLQAIGLFA 1003

  Fly   857 SSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQI 921
            |...:|....:||..|..::...|.|:.:.||.....|::||||:|:...||..:|..:..::..
  Rat  1004 SMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTY 1068

  Fly   922 ALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGL 986
            |..|..:.:.::...||.:|..|.|.:::...::||:.|...|:|:|:.:.|.|.||||.:..|.
  Rat  1069 AFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQGS 1133

  Fly   987 TTIRALDAQRVLEKEFDSYQDAHSSAFFMYI-------STSQAFGYCMNCICVIYISIITLSFFA 1044
            ..:||..||.....:.|:..|.:....|..:       :..:..|   |.:..:..:...||...
  Rat  1134 QVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLG---NGLVFVAATCAVLSKAH 1195

  Fly  1045 FPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPK 1109
            ...|.   .|..::.|:.:...:||.||...:|||:|.|||||.:|.....|.....|.....|
  Rat  1196 LSAGL---AGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQP- 1256

  Fly  1110 TWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTD 1173
            .||..|:|.|::..||:.|  :....::.:|..|...||||||||||||||||...|.|| ..|:
  Rat  1257 LWPCGGQIEFRDFGLRHRP--ELPMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATE 1319

  Fly  1174 GSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVS 1238
            |.:.||......||||.||.:|:||||:||||.|::|.|||...|.:||.:|..||.|:||..|:
  Rat  1320 GGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFVT 1384

  Fly  1239 DLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRD 1303
            .||..|..:.|..|.:.||||:||:|||||:||:.:||::|||||:|||.|:..:||.:...|..
  Rat  1385 SLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEIQMQAALERWFAQ 1449

  Fly  1304 CTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRA 1358
            ||||.|||||.::::..:|:|||.|:|.|.|||.:|:.:..  :|:.|..:||.|
  Rat  1450 CTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQKG--LFYRLAQESGLA 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	416/1329 (31%)
		ABC_membrane	171..437	CDD:294371	60/271 (22%)
		ABCC_MRP_domain1	499..699	CDD:213217	93/201 (46%)
		ABC_membrane	799..1045	CDD:294371	61/258 (24%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	110/221 (50%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	422/1352 (31%)
		ABC_membrane	313..577	CDD:294371	59/270 (22%)
		ABCC_MRP_domain1	627..828	CDD:213217	93/201 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		5/54 (9%)
		ABC_membrane	950..1215	CDD:294371	65/284 (23%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	110/221 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650