DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and ABCC13

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001323940.1	Gene:	ABCC13 / 815414	AraportID:	AT2G07680	Length:	1426	Species:	Arabidopsis thaliana

Alignment Length:	1318	Identity:	410/1318 - (31%)
Similarity:	673/1318 - (51%)	Gaps:	109/1318 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KVLP-ENP---------RARSN--FISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGN 136
            |::| |:|         |...|  :.....|.|...|.:.|..|.|:..:|.....|........
plant   171 KIIPLEDPLIEDDDDQKRIEKNGSWWDLFTFGYIGSIMKHGSVKQLELENLLTLPPEMDPFTCCE 235

  Fly   137 RLCASWERELKNDGRSPSLVRALLRVFGW---QLGFPGLAIFVVELGLRTLQPIFLVKLISYFSG 198
            .|...|:.:..|:..:|||:.::..|:||   :||.  |.:|...:|.  ..|:.|.:||.|..
plant   236 NLLRCWQLQECNNYSTPSLIWSIYGVYGWPYFRLGL--LKVFNDCIGF--AGPLLLNRLIKYLE- 295

  Fly   199 EPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTS 263
            :...::.|:..|::...||.....:.|..||.:..:..|:|.::.|:|:||.|.:........:.
plant   296 KGSGSSVGYTLAISLGFISIFKSFLDTQYTFRLSKLKLKLRSSIMSVIYRKCLWVNTANRSGFSE 360

  Fly   264 GHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGT 328
            |.:...:|.|..|:.:...::|.||..|||:.:..||:|.::..:.:.|:...:|.:|:..::..
plant   361 GEIQTFMSVDADRIVNLCNSLHDLWSLPLQIGIALYLLYTQVKFAFLSGLAITILLIPVNKWISV 425

  Fly   329 RTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRG--- 390
            ..::...|..:..|.|||...|:::.|:.||||.|:..|...:...|..|:..:...:|:..
plant   426 LIASATEKMMKLKDERIRKTGELLTNIRTLKMYGWDNWFADWLKETRATEVTHLATRKYLDAWCV 490

  Fly   391 FDFARRIVLSRVAIFLSLVG-YVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTS 454
            |.:|....|..:..|    | :.::|........|...|.:|.|::.::.: |..|........|
plant   491 FFWATTPTLFSLCTF----GLFALMGHQLDAATVFTCLALFNSLISPLNSF-PWVINGLIDAFIS 550

  Fly   455 IRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPN-SPDY--T 516
            .|||.:|:...|         .|:|.   :..|.....||   |:.:.|....|..| ..||  |
plant   551 TRRVSKFLCCLE---------HSRDF---SIDSGFTSEDL---AVCVEDASCTWSSNVEEDYNLT 600

  Fly   517 LSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQN 581
            :..::|.:..||.|||||..||||:||:.::|||::...|.:.:|||::|..|..||.|||||:|
plant   601 IKQVSLRVPKGSFVAVIGEVGSGKTSLLNSLLGEMRCVHGSILLNGSVAYVPQVPWLLSGTVREN 665

  Fly   582 ILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYL 646
            ||||:|.||:||.|.:..|||:.|..|:...|...:|::|..|||||:||.:|||:||..:.:||
plant   666 ILFGKPFDSKRYFETLSACALDVDISLMVGGDMACIGDKGLNLSGGQRARFALARAVYHGSDMYL 730

  Fly   647 LDDPLSAVDASVARHLFDQCVRGH-LRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLL 710
            |||.|||||:.|...:..:.:.|. |...|.|:.||..|.:...|.||::..|::...|....:.
plant   731 LDDVLSAVDSQVGCWILQRALLGPLLNKKTRVMCTHNIQAISCADMIVVMDKGKVNWSGSVTDMP 795

  Fly   711 KTGLITGLGSLSKTDKAKTEEQEPLNLNSPDN---KNEVTPIKENSEQTVGGSSSGKEHVERQES 772
            |        |:|.|.....|    .:::||::   :.|...|||:....:..:::....:|.::.
plant   796 K--------SISPTFSLTNE----FDMSSPNHLTKRKETLSIKEDGVDEISEAAADIVKLEERKE 848

  Fly   773 GGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMESKS 837
            |.:.:.:||.|....|..:. :|:|.|:||.|.:..|.|.:|:|||.|......|        .|
plant   849 GRVEMMVYRNYAVFSGWFIT-IVILVSAVLMQGSRNGNDLWLSYWVDKTGKGVSH--------YS 904

  Fly   838 MDVYKYTLII--ILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRF 900
            ...|...|.|  |::.|:.|..:|.......||::.:||.:.:::..|...||.....|.|||||
plant   905 TSFYLMVLCIFCIINSILTLVRAFSFAFGGLKAAVHVHNALISKLINAPTQFFDQTPSGRILNRF 969

  Fly   901 TKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLK 965
            :.|:..:|:.||.:|..::...:.|.|||:|::.|..|.|:..|....|:..|:..|..|||:|:
plant   970 SSDLYTIDDSLPFILNILLANFVGLLGIIVVLSYVQVLFLLLLLPFWYIYSKLQVFYRSTSRELR 1034

  Fly   966 RVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTS-------QAF 1023
            |:::::|||:|:....:|:|.:||||..::......|..:...:....:..|..|       |..
plant  1035 RLDSVSRSPIYASFTETLDGSSTIRAFKSEEHFVGRFIEHLTLYQRTSYSEIIASLWLSLRLQLL 1099

  Fly  1024 GYCMNCICVIYISIITL--SFFAFPPGNGAD--VGLVITQAMGLIDMVQWGVRQTAELENTMTAV 1084
            |    .:.|::::::.:  |...||...|..  |||.::.|..|:.::...:....|.|..|.:|
plant  1100 G----SMIVLFVAVMAVLGSGGNFPISFGTPGLVGLALSYAAPLVSLLGSLLTSFTETEKEMVSV 1160

  Fly  1085 ERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRY---TPNAKAENVLKSLSFVI 1143
            |||::|..: |:..:..|   .||     ||..|.:.|..:.:||   .|.|     |..:||.|
plant  1161 ERVLQYMDV-PQEEVSGPQSLSDK-----WPVHGLVEFHNVTMRYISTLPPA-----LTQISFTI 1214

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRLS-YTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            |....||::|||||||||::||||||: ...|.:|:|.::...:.:.:||..::::||.|.||.|
plant  1215 QGGMHVGVIGRTGAGKSSILNALFRLTPVCSGEILVDGKNISHLPIRELRSCLAVVPQSPFLFQG 1279

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRE 1272
            ::|.||||.....|.::|..|::.|:|..|..: .||.|.:.|.|.:||||||||:|||||:|:.
plant  1280 SLRDNLDPLGLSEDWRIWEILDKCKVKAAVESV-GGLDSYVKESGCSFSVGQRQLLCLARALLKS 1343

  Fly  1273 NRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPY 1337
            ::||.:||.|||:|..|..|:..||.|:.:..||:|||||:.|::|.|.::::|.|.:||.|.|.
plant  1344 SKILCLDECTANIDVHTASLLHNTISSECKGVTVITIAHRISTVVDLDSILILDRGILVEQGKPQ 1408

  Fly  1338 ELMTKSDSKVFHNLVNQS 1355
            .|: :.||..|.:.|..|
plant  1409 HLL-QDDSSTFSSFVRAS 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	402/1298 (31%)
		ABC_membrane	171..437	CDD:294371	64/269 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	88/203 (43%)
		ABC_membrane	799..1045	CDD:294371	72/256 (28%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	97/224 (43%)
ABCC13	NP_001323940.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720