DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcc3

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001350116.1	Gene:	Abcc3 / 76408	MGIID:	1923658	Length:	1523	Species:	Mus musculus

Alignment Length:	1381	Identity:	479/1381 - (34%)
Similarity:	748/1381 - (54%)	Gaps:	152/1381 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 KEK---VLPEN------PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNR 137
            |||   ..|||      |.|.:.|.|.|.||:...:...|||:.|:..||:...||..|..:..|
Mouse   191 KEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQR 255

  Fly   138 LCASWERELKNDGRS-------------------------PSLVRALLRVFGWQLGFPGLAIFVV 177
            |..:|:::.....||                         ||.:|||:|.|...|........:.
Mouse   256 LLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQ 320

  Fly   178 ELGLRTLQPIFLVKLISYFSGEPDAAN-AGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVA 241
            .| |..:.|..|..||.:.| :|.|.. .||..|....:.|.:..:||......|..:..::|.|
Mouse   321 NL-LGFVNPQLLSILIRFIS-DPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTA 383

  Fly   242 MGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPR-LDSAPYTVHYLWVGPLQVLVITYLMYQEI 305
            :..:|:||||.:|.....::|.|.:|||:|.|..| :|.:|: ::.||..||||::..|.::|.:
Mouse   384 IIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPF-INLLWSAPLQVILAIYFLWQIL 447

  Fly   306 GISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQM 370
            |.||:.||..::|.:|:...:..:....|:|..:..|:||::::||::.|:|||:||||..|.:.
Mouse   448 GPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQ 512

  Fly   371 VTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL--GKVFTPEIAFMITAYYNVL 433
            |...|:.|:..:|:|.|::.......|....:...::|..||.:  ..|...|.||:..:.:|:|
Mouse   513 VKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNIL 577

  Fly   434 LAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSA 498
            ...::: :|..|....|...|::|::.|:...||   |......|...||             .|
Mouse   578 KIPLNM-LPQLISGLTQASVSLKRIQDFLNQNEL---DPQCVERKTISPG-------------YA 625

  Fly   499 ISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGS 563
            |:|.:....|..:.|. ||..:|::|..|::|||:|..|.|||||:.|:|||::...|.:.|.||
Mouse   626 ITIHNGTFTWAQDLPP-TLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGS 689

  Fly   564 LSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQ 628
            ::|..|::|:.:.|:::|:||||||:.:||::.::.|||..|.|:||..|.|.:||:|..|||||
Mouse   690 VAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQ 754

  Fly   629 KARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQ 691
            :.|:||||:||..|:|:||||||||||:.||:|:|||.:  .|.|.|.|.|||||...|||..|.
Mouse   755 RQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDF 819

  Fly   692 IVILANGQIKALGDYESLLKTGLITGLGSLSK--TDKAKTEEQEP-----LNLNS---------- 739
            |::||.||:..:|.|.:||:..     ||.:.  .:.|..|:||.     .|.|.
Mouse   820 IIVLAGGQVSEMGHYSALLQHD-----GSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLS 879

  Fly   740 -----PDNKNEVTPIKE---------NSEQTVGGSSSGKEHV---------------------ER 769
                 .||:..:..:::         :||..|...:..|:|.                     |.
Mouse   880 THTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEI 944

  Fly   770 QESGGISLALYRKYFQAGGGLVAFLVMLSSSVL---AQVAVTGGDYFLTYWVKKESTAAGHGEME 831
            .|:|.:.|::|..|.::.|    ....||..:|   ...|..|.:.:|:.|   .:.|..||:
Mouse   945 AETGNVKLSVYWDYAKSMG----LCTTLSICLLYGGQSAAAIGANVWLSAW---SNDAEEHGQ-- 1000

  Fly   832 DMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSI 896
             ....|:.:..|..:.||..::.:.|:|.:...|.:|:..||..:.:...|:...||.....|.|
Mouse  1001 -QNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRI 1064

  Fly   897 LNRFTKDMSQVDEVL-PVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKT 960
            ||||:||:..:|||| |.:|:.:......::.|::::|: .||.:|..|.|:|::..::..|:.|
Mouse  1065 LNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVAS-TPLFMVVVLPLAVLYGFVQRFYVAT 1128

  Fly   961 SRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFG- 1024
            ||.|||:|:|:|||::||.:.::.|.:.|||....:..:...|:..|.:..:.:.||::::..|
Mouse  1129 SRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGV 1193

  Fly  1025 ---YCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVER 1086
               :..||:.:.......:...:..||.   |||.::.|:.:...:.|.:|..::||:.:.||||
Mouse  1194 HVEFVGNCVVLFAALFAVIGRNSLNPGL---VGLSVSYALQVTMALNWMIRMISDLESNIIAVER 1255

  Fly  1087 VVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREK 1148
            |.||...:    .|||   :..:.|:.||.:|.:.|:..::||.|.  .|.|||:::..:|..||
Mouse  1256 VKEYSKTK----TEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPG--LELVLKNVTVHVQGGEK 1314

  Fly  1149 VGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYN 1212
            |||||||||||||:...||| |...:|.::||..:...:||||||.|::||||:|:|||||:|.|
Mouse  1315 VGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMN 1379

  Fly  1213 LDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILV 1277
            ||||..||:|.:|..||...|...||..|.||..:.:|||.|.|||||||||||||:||::|:||
Mouse  1380 LDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLV 1444

  Fly  1278 MDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTK 1342
            :|||||.:|.:||.|||.|||::|.|||||||||||:||:|.::|:|:|.|.|.||.||..|:..
Mouse  1445 LDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAA 1509

  Fly  1343 SDSKVFHNLVNQSGRA 1358
            ..  :|:.:...:|.|
Mouse  1510 GG--IFYGMAKDAGLA 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	471/1354 (35%)
		ABC_membrane	171..437	CDD:294371	81/269 (30%)
		ABCC_MRP_domain1	499..699	CDD:213217	98/201 (49%)
		ABC_membrane	799..1045	CDD:294371	68/253 (27%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	125/221 (57%)
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	477/1378 (35%)
Abcc3	NP_001350116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..923		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660