DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and ABCC8

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_016873686.1 Gene:ABCC8 / 6833 HGNCID:59 Length:1604 Species:Homo sapiens


Alignment Length:1410 Identity:434/1410 - (30%)
Similarity:718/1410 - (50%) Gaps:184/1410 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGN--RLCASWERELKNDGRSPSLV 156
            |.:|...:|:.....:..::|.:|...:.: |:..:   .|.|  |||.:::.:::.|.:.....
Human   223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMR---ALTNYQRLCEAFDAQVRKDIQGTQGA 284

  Fly   157 RAL-----------------LRVFGWQLGFPG-LAIFVVELGLRTLQPIFLVKL----ISYFSGE 199
            ||:                 .|:....|||.| |.||.:...|.....:|..|.    :.:.|.:
Human   285 RAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQ 349

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKALRLTKG-- 256
            ...|||   |.:|.::..||    |...||  ..::|..:    :|.|:.:.|:.|.:.|:..  
Human   350 EFLANA---YVLAVLLFLAL----LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNL 407

  Fly   257 ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMP 321
            ::|:.|:|.:.||::.|..:|....:....||..|:|::|...|:|..:|:||:.|...::|..|
Human   408 SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAP 472

  Fly   322 IQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQ 386
            :|.::.|:.|..|....|.::.|::..||::..|::||:||||..|...|...|.|||.::|...
Human   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFA 537

  Fly   387 YIRGFDFARRIVLSRVAIFLSLVGYVILGKV--FTPEIAFMITAYYNVLLAAMSIYVPSAIIQTA 449
            ............:...|:.::.||:|...|.  |:|.:||...:.:::|:..:.: :.|.:..|.
Human   538 IYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFL-LSSVVRSTV 601

  Fly   450 QFLTSIRRVEQFMQSEEL-------------GSSDK------------SEGPSKDTVPGNP---- 485
            :.|.|::::.:|:.|.|:             |.:.|            |..||..:.|.:|    
Human   602 KALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLR 666

  Fly   486 -----------------------PSNNNEADLLKSAISIRDLKAKWDPNS-PDYTLSGINLEIKP 526
                                   ||.:.:||  ...:.|......|.|:. |  |||.|.:.|..
Human   667 VVNRKRPAREDCRGLTGPLQSLVPSADGDAD--NCCVQIMGGYFTWTPDGIP--TLSNITIRIPR 727

  Fly   527 GSVVAVIGLTGSGKSSLIQAILGELKANSG---------------------------QLQVNGSL 564
            |.:..::|..|.|||||:.|.|||::..||                           .::..|.:
Human   728 GQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPV 792

  Fly   565 SYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQK 629
            :|.||:.||.:.||.:||:|..|.:.|||:.|::.|:|:.|.|:||..|.|.:||||..|||||:
Human   793 AYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 857

  Fly   630 ARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQI 692
            .|||:||::|:.|::..||||.||:|..::.||....:...||..  |||||||:.|:|||.|.|
Human   858 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWI 922

  Fly   693 VILANGQIKALGDYESL----------LKTGLITGLGSLSK---TDKAKTEEQEPLNLNSPDNKN 744
            :.:.:|.|:..|..:..          .||.:......|.|   |::..||..:.|: .:..:::
Human   923 IAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLS-RAMSSRD 986

  Fly   745 EVTPIKENSEQTVGGSSSGKEHVERQESGGISLALYR----------KYFQAGGGLVAFLVMLSS 799
            .:...:|..|:         |..|.:|...:|..|::          ||..:.|.|:..|::. |
Human   987 GLLQDEEEEEE---------EAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVF-S 1041

  Fly   800 SVLAQVAVTGGDYFLTYWVKKEST---AAGHGEMEDMESKSMDVYK--YTLIIILSVIMNLSSSF 859
            .:|..:.:...||:|..|.....|   ||.:..:....:....||.  :|::..|.:::.|.:|.
Human  1042 QLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSV 1106

  Fly   860 LLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALW 924
            .:.....|.:.|||.::.||:..|.|.||.....|||||||:.|.:.:|:.:|..|..:.:..|.
Human  1107 TVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLL 1171

  Fly   925 LAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTI 989
            ....:.||:.|.|:.||..|.|:::.|.::..:...||||::::...:.|:.||.|.::.|||||
Human  1172 CVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTI 1236

  Fly   990 RALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI--CVIYISIIT-LSFFAFPPGNGA 1051
            ||...:...:::...|.|:::.|.....:.::.....|..|  ||:.|:.:| :|.......:..
Human  1237 RAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAG 1301

  Fly  1052 DVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERV---VEYESIEPEGMLEAPDDKKPPKTWPE 1113
            .|||.:|.|:.:.:.:.|.||..|::|..:.||:|:   ::.|:...||:| ||  ...||.||:
Human  1302 LVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLL-AP--SLIPKNWPD 1363

  Fly  1114 QGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVL 1177
            ||:|..:.|::||..:.|.  |||.::.:|.|.:|:||.||||:||||...|.||:..| :|.::
Human  1364 QGKIQIQNLSVRYDSSLKP--VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHII 1426

  Fly  1178 IDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPD 1242
            ||..|..::.||.||.::|||.|:|||||||:|:||||..:.||..||..||..:||.||..||.
Human  1427 IDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPG 1491

  Fly  1243 GLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVL 1307
            ||.:.|:|||.|||.|||||.|||||.:|:..|.:||||||::|..|:.::|..:.:.|.|.||:
Human  1492 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVV 1556

  Fly  1308 TIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            |||||:|||:.:|.|:|:..|.::||..|.:|:::.|| ||.:.|
Human  1557 TIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS-VFASFV 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 429/1399 (31%)
ABC_membrane 171..437 CDD:294371 76/280 (27%)
ABCC_MRP_domain1 499..699 CDD:213217 87/229 (38%)
ABC_membrane 799..1045 CDD:294371 71/253 (28%)
ABCC_MRP_domain2 1115..1336 CDD:213211 110/221 (50%)
ABCC8XP_016873686.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151575
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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