Protein Alignment l(2)03659 and ABCC8

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001338224.1
• Gene: ABCC8 / 6833
• HGNCID: 59
• Length: 1603
• Species: Homo sapiens
• Alignment Length: 1409
• Identity: 434/1409 - (30%)
• Similarity: 718/1409 - (50%)
• Gaps: 183/1409 - (12%)

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYR-PLEEQKSDILGN--RLCASWERELKNDGRSPSLV 156
            |.:|...:|:.....:..::|.:|...:.: |:..:   .|.|  |||.:::.:::.|.:.....
Human   223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMR---ALTNYQRLCEAFDAQVRKDIQGTQGA 284

  Fly   157 RAL-----------------LRVFGWQLGFPG-LAIFVVELGLRTLQPIFLVKL----ISYFSGE 199
            ||:                 .|:....|||.| |.||.:...|.....:|..|.    :.:.|.:
Human   285 RAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQ 349

  Fly   200 PDAANAGFYYAVAQIVISALTVMILTPTTF--GIHHVCFK----MRVAMGSMIFRKALRLTKG-- 256
            ...|||   |.:|.::..||    |...||  ..::|..:    :|.|:.:.|:.|.:.|:..
Human   350 EFLANA---YVLAVLLFLAL----LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNL 407

  Fly   257 ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMP 321
            ::|:.|:|.:.||::.|..:|....:....||..|:|::|...|:|..:|:||:.|...::|..|
Human   408 SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAP 472

  Fly   322 IQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQ 386
            :|.::.|:.|..|....|.::.|::..||::..|::||:||||..|...|...|.|||.::|...
Human   473 VQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFA 537

  Fly   387 YIRGFDFARRIVLSRVAIFLSLVGYVILGKV--FTPEIAFMITAYYNVLLAAMSIYVPSAIIQTA 449
            ............:...|:.::.||:|...|.  |:|.:||...:.:::|:..:.: :.|.:..|.
Human   538 IYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFL-LSSVVRSTV 601

  Fly   450 QFLTSIRRVEQFMQSEEL-------------GSSDK------------SEGPSKDTVPGNP---- 485
            :.|.|::::.:|:.|.|:             |.:.|            |..||..:.|.:|
Human   602 KALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLR 666

  Fly   486 -----------------------PSNNNEADLLKSAISIRDLKAKWDPNS-PDYTLSGINLEIKP 526
                                   ||.:.:||  ...:.|......|.|:. |  |||.|.:.|..
Human   667 VVNRKRPAREDCRGLTGPLQSLVPSADGDAD--NCCVQIMGGYFTWTPDGIP--TLSNITIRIPR 727

  Fly   527 GSVVAVIGLTGSGKSSLIQAILGELKANSG--------------------------QLQVNGSLS 565
            |.:..::|..|.|||||:.|.|||::..||                          .::..|.::
Human   728 GQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVA 792

  Fly   566 YTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKA 630
            |.||:.||.:.||.:||:|..|.:.|||:.|::.|:|:.|.|:||..|.|.:||||..|||||:.
Human   793 YASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQ 857

  Fly   631 RISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIV 693
            |||:||::|:.|::..||||.||:|..::.||....:...||..  |||||||:.|:|||.|.|:
Human   858 RISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII 922

  Fly   694 ILANGQIKALGDYESL----------LKTGLITGLGSLSK---TDKAKTEEQEPLNLNSPDNKNE 745
            .:.:|.|:..|..:..          .||.:......|.|   |::..||..:.|: .:..:::.
Human   923 AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLS-RAMSSRDG 986

  Fly   746 VTPIKENSEQTVGGSSSGKEHVERQESGGISLALYR----------KYFQAGGGLVAFLVMLSSS 800
            :...:|..|:         |..|.:|...:|..|::          ||..:.|.|:..|::. |.
Human   987 LLQDEEEEEE---------EAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVF-SQ 1041

  Fly   801 VLAQVAVTGGDYFLTYWVKKEST---AAGHGEMEDMESKSMDVYK--YTLIIILSVIMNLSSSFL 860
            :|..:.:...||:|..|.....|   ||.:..:....:....||.  :|::..|.:::.|.:|..
Human  1042 LLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVT 1106

  Fly   861 LFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWL 925
            :.....|.:.|||.::.||:..|.|.||.....|||||||:.|.:.:|:.:|..|..:.:..|..
Human  1107 VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLC 1171

  Fly   926 AGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIR 990
            ...:.||:.|.|:.||..|.|:::.|.::..:...||||::::...:.|:.||.|.::.||||||
Human  1172 VSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIR 1236

  Fly   991 ALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI--CVIYISIIT-LSFFAFPPGNGAD 1052
            |...:...:::...|.|:::.|.....:.::.....|..|  ||:.|:.:| :|.......:...
Human  1237 AFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGL 1301

  Fly  1053 VGLVITQAMGLIDMVQWGVRQTAELENTMTAVERV---VEYESIEPEGMLEAPDDKKPPKTWPEQ 1114
            |||.:|.|:.:.:.:.|.||..|::|..:.||:|:   ::.|:...||:| ||  ...||.||:|
Human  1302 VGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLL-AP--SLIPKNWPDQ 1363

  Fly  1115 GEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLI 1178
            |:|..:.|::||..:.|.  |||.::.:|.|.:|:||.||||:||||...|.||:..| :|.::|
Human  1364 GKIQIQNLSVRYDSSLKP--VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIII 1426

  Fly  1179 DTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDG 1243
            |..|..::.||.||.::|||.|:|||||||:|:||||..:.||..||..||..:||.||..||.|
Human  1427 DGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGG 1491

  Fly  1244 LASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLT 1308
            |.:.|:|||.|||.|||||.|||||.:|:..|.:||||||::|..|:.::|..:.:.|.|.||:|
Human  1492 LDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVT 1556

  Fly  1309 IAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            ||||:|||:.:|.|:|:..|.::||..|.:|:::.|| ||.:.|
Human  1557 IAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDS-VFASFV 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	434/1409 (31%)
ABCC8	NP_001338224.1	MRP_assoc_pro	224..1600	CDD:188098	433/1408 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1009		11/61 (18%)