DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc12

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_009301629.1	Gene:	abcc12 / 568482	ZFINID:	ZDB-GENE-050517-25	Length:	1368	Species:	Danio rerio

Alignment Length:	1408	Identity:	459/1408 - (32%)
Similarity:	765/1408 - (54%)	Gaps:	133/1408 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ESSLLENNGFDHRNKDESLSVNT---SPPLVCRKCFELGHQTENCKQKLTVNSENNSAQNEKEKV 85
            |...:|...|..| :|.|.:::.   .||::..:..|...:....:|.|........|.|
Zfish     7 EKQKVEGVSFKQR-RDSSSAMSAFPEGPPVLDYREPEPPPKKHKYQQSLKTLIPFRFASN----- 65

  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDG 150
              .:|...:.|.|...|.:..|:..:.:|..||...|:.. ....:.|.|.|....|:.|:...|
Zfish    66 --SHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLFLS-PHDGAHINGERFQRLWDEEVARVG 127

  Fly   151 RSPSLVRALLRVF---GWQLGFPG--LAIFVVELGLRTLQPIFLV-KLISYF-SGEPDAANAGFY 208
            ...:.:.|::..|   .:.:.|..  :..|.|.:|     |..|| ::::|. ..||.....|..
Zfish   128 LEKASLSAVIMRFQKTRFIVSFLASVMFAFAVFVG-----PSILVYEILNYVEQSEPSTVVHGVG 187

  Fly   209 YAVAQIVISALTVMILTPTTFGIH-HVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISN 272
            ..|| :.::..:........:.:: ....:::.|...:.|:|.:.|.  :|...|.|..:|::::
Zfish   188 VCVA-LFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISLR--SLTTITVGETINVLTS 249

  Fly   273 DIPRL-DSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336
            |..|| |:..:....|.|..|.::.|.|..: .:|.:|:.|:|..|:|:|||..:.......:.:
Zfish   250 DGYRLFDAVIFGTFLLCVPVLLIICIIYACF-ILGYTALIGILVYLIFLPIQFSIARLIGVFRRR 313

  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR 401
            |...||.|:|.:||:::.|:::||||||:.||:.:|..|:.|...:::..|::..:.:...::..
Zfish   314 AVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSLNSSLTTIVPT 378

  Fly   402 VAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSI--YVPSAIIQTAQFLTSIRRVEQFMQS 464
            :|..::.:.:..|.....|..|:.|.|.:|.:..:|.:  :...|:.:....||.::|:......
Zfish   379 LATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSMGLLPFSVKAVAEAKVALTRLKRIMLVQNP 443

  Fly   465 EELGSSDK-------------SEGPSKD----TVPGNPPSNNNEADLLKSAISIRDLKAKWDPNS 512
            :...:.||             |..|:.|    .:|.||..|...             ||:..|
Zfish   444 KGYLTQDKNMDLALVMEKATFSWSPTDDKNTSQMPENPSQNGKH-------------KAESQP-- 493

  Fly   513 PDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGT 577
               :|..|:|.:..||::.|.|..||||:|||.:||.::...||.:..||:|:|.||::|:|.||
Zfish   494 ---SLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGTLAYVSQQAWIFHGT 555

  Fly   578 VRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKA 642
            ||.|||.|:|.|..||..|:..|.|:.|..:||..|.|.:||||..||||||.|:||||:||...
Zfish   556 VRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVSLARAVYSNR 620

  Fly   643 SIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYE 707
            .|:|||||||||||.|.:|:|::|::..|:|.:|:|||||.|:|...|::::|.||:||..|.:.
Zfish   621 DIFLLDDPLSAVDAHVGKHIFEECIKKELKGKSVILVTHQLQYLEFCDEVMLLDNGEIKEAGTHS 685

  Fly   708 SLLKT-----GLITGLGSLSKTDKAKTEEQ------EPLNLNSP-------------DNK---NE 745
            .|:||     .|||.:......::|.::.|      |..|.:.|             |.|   ||
Zfish   686 DLMKTKGRYSQLITNVHLEQNNERADSKPQTEHNDSEQTNPDEPKANGIENPAFDMSDEKPATNE 750

  Fly   746 VTPIKENSEQTVGGSSSGKEH--VERQ--ESGGISLALYRKYFQAGGG-LVAFLVMLSSSVLAQV 805
             || |::||      :.||:.  |.|:  :.|.::...|.:|.||.|| ::.|||:|..::|  |
Zfish   751 -TP-KDSSE------TKGKKDQLVTREVAQEGSVTWRTYHQYCQAAGGYILLFLVVLLFTLL--V 805

  Fly   806 AVTG-GDYFLTYWVKKESTAAGHGEMEDMESKSMDVYK----------YTLIIILSVIMNLSSSF 859
            ..|. .:::|:||:.:.|   |:....:..|.|.::.:          |.:|||..:::::...:
Zfish   806 GSTAFSNWWLSYWLDQGS---GNNSSSNATSNSGNISENPDLSFYQMVYGVIIIAMIVLSILKGY 867

  Fly   860 LLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALW 924
            ....:..::|.:||:|:|.|:..:.|.||.....|.::|||:||..:||.|||..:.:.:|..|.
Zfish   868 TFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLI 932

  Fly   925 LAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTI 989
            :...::.|..|.|.||:..::|.:||..:..::.::.|.:||:|.::|||..|...:::.||:||
Zfish   933 VTFTLLTICIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTI 997

  Fly   990 RALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPG---NGA 1051
            .|.|.::...:.|....|.:|:.|.::.:.::...:.::.:......|::| |....|.   |.:
Zfish   998 HAYDKRQQYIERFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSL-FVVLSPNETINPS 1061

  Fly  1052 DVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAPDDKKPPKTWPEQG 1115
            ..||.::..:.|..::|:.||.:.|:|...|:|||::|| .|...||.... .|...|..||::|
Zfish  1062 LKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGPRRV-KDANIPAGWPQEG 1125

  Fly  1116 EIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSY-TDGSVLID 1179
            .|.||..::||..|...  ||.:|:..|:|.||:|||||||:|||||..|||||:. .:|::|||
Zfish  1126 TITFKNYSMRYRDNTPI--VLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTILID 1188

  Fly  1180 TRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGL 1244
            ..|..::||.|||.|:|:|||:||||.||:|||||||:.|.||:||..||:..:|:.:|.||:.|
Zfish  1189 DMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLPEKL 1253

  Fly  1245 ASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTI 1309
            .|.:.|.|.|||||:|||:|:|||:||.::|:::|||||::|.:||.|||.|||..|:.||:|||
Zfish  1254 QSPVVENGENFSVGERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTMLTI 1318

  Fly  1310 AHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLV 1352
            |||::|:::||:::|||.|:|:||..|.:|:.:.:| :|.:|:
Zfish  1319 AHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPNS-LFASLL 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	443/1329 (33%)
		ABC_membrane	171..437	CDD:294371	65/271 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	95/199 (48%)
		ABC_membrane	799..1045	CDD:294371	65/256 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	122/221 (55%)
abcc12	XP_009301629.1	CFTR_protein	68..1366	CDD:273530	446/1339 (33%)
		ABC_membrane	149..414	CDD:294371	66/273 (24%)
		ABCC_MRP_domain1	457..677	CDD:213217	102/237 (43%)
		ABC_membrane	809..1077	CDD:294371	67/271 (25%)
		ABCC_MRP_domain2	1125..1345	CDD:213211	122/221 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660