DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc6a

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_009300481.1	Gene:	abcc6a / 566555	ZFINID:	ZDB-GENE-050517-18	Length:	1507	Species:	Danio rerio

Alignment Length:	1360	Identity:	452/1360 - (33%)
Similarity:	712/1360 - (52%)	Gaps:	138/1360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KVLPEN--PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSD-------------- 132
            |.:.:|  |...::|:|.:.||:...:..||||..|.:.||:...||..|:
Zfish   197 KAVHKNACPVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLEEEWTAKR 261

  Fly   133 --------------ILGNRL--CASWERELKNDGRSP-SLVRALLRVFGWQLGFPGLAIFVVELG 180
                          .||:||  .|...|:::.:..|. .|:|.|.|.||.......|.:.|.::.
Zfish   262 TKLQQQENHMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTLARSFGPYFLTGTLCLIVHDVF 326

  Fly   181 LRTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSM 245
            :.:: |..|..|:.:...|......|::||....::|.|..:.....|:....|..:::.|:..:
Zfish   327 MFSV-PQVLSLLLGFMKDEDTPLWKGYFYATLMFLLSCLQSVFNHQYTYTCFTVGMRVKTAVMGL 390

  Fly   246 IFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHY--LWVGPLQVLVITYLMYQEIGIS 308
            ::||:|.:...|....|.|.:|||:|.|..:|  ..:.|::  :|:.|::|.:..:.::|.:|.|
Zfish   391 VYRKSLVMNSSARRTCTVGEIVNLVSADTQKL--MDFVVYFNAVWLAPIEVTLCLFFLWQHLGPS 453

  Fly   309 AVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTH 373
            |:.|:..::...|:..::..:.|.:|....:..|.|::::|||::.|::||.||||:.|.:.|..
Zfish   454 ALAGIATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILNGIKILKFYAWEKAFLEQVLG 518

  Fly   374 AREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILG--KVFTPEIAFMITAYYNVLLAA 436
            .||||:.|:::.|.:.....|.....|.:..|.....||::.  .|...:..|:..|..|:|...
Zfish   519 YREKELKTLKKSQILYSVSLASFNSSSFLIAFAMFGVYVLIDDKNVLDAQKIFVSMALINILKTP 583

  Fly   437 MSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISI 501
            :| .:|.|:..|.|.|.|::|:.:|:..:||...:.:....|..|.|....|..
Zfish   584 LS-QLPFAMSTTMQALVSLKRLGKFLCQDELKPDNVARESFKSDVDGVVFDNGT----------- 636

  Fly   502 RDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSY 566
                ..|..:.|. .|..|::::..||:|||:|..|||||||:.|:|||.:..||.:.|.||::|
Zfish   637 ----FSWSKDGPP-CLKRISVKVPCGSLVAVVGHVGSGKSSLLSAMLGETEKRSGTVSVKGSIAY 696

  Fly   567 TSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKAR 631
            ..|::|:.:.:::.|||||:......|:.|::.|||..|.|.||..|.|.:||:|..||||||.|
Zfish   697 VPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAGDATEIGEKGLNLSGGQKQR 761

  Fly   632 ISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVI 694
            :||||:||||..:||||||||||||.|.:|:|::.:  :|.||..|.|||||...|||..|.|::
Zfish   762 VSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKTRVLVTHGMSFLPQADLILV 826

  Fly   695 LANGQIKALGDYESLL-KTGLITGL-------------------GS-----LSKTDK---AKTEE 731
            |.:|:|...|.|:.|| :.|.....                   ||     ||.||.   ::...
Zfish   827 LVDGEISERGSYQELLNRNGAFADFIHTFANSERKECFSEALQRGSRKSVRLSVTDYMPFSRDLS 891

  Fly   732 QEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGISLALYRKYFQA-GGGLVAFLV 795
            ||.| :....|...:.|:.::.|..:.........|::...|.:.|.:|.:||:. |..|:..:|
Zfish   892 QEQL-IGGDTNSIAIEPLPDSDEDHIPEDLGKLTKVDKARIGRVKLEMYIEYFRTIGLPLIISIV 955

  Fly   796 MLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDME---------SKSMDVYKYTLIIILSV 851
            .|.:  ..|.|....:|:|:.|. .:....|.....|::         ::.:.::..|:.|.|..
Zfish   956 FLYA--FQQAASLSNNYWLSLWA-DQPVINGTQLNTDLKLGVYGALGFAQGISIFGTTVAISLGC 1017

  Fly   852 IMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLV 916
            |:              ||..||..:.|.|..:.|.||.....|::||||.|::..:|.::|..|.
Zfish  1018 II--------------ASRHLHLDLLNNVLHSPMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLK 1068

  Fly   917 DVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAA 981
            .::.....|..:.|::....|...|..|.:..::..:::.|:.||..|:|:|:::|||:|:||..
Zfish  1069 MMLSYFFKLTEVCIIVLMATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNE 1133

  Fly   982 SLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI---CVIYISII----- 1038
            ::.|.:.|||.:.|.......:...|.:.:|:|.....::..|..:..:   .|:..||:
Zfish  1134 TVQGASVIRAFNEQSRFIMGANHKVDHNQTAYFPRFIATRWLGVNLEFLGNGIVLAASILSVMAK 1198

  Fly  1039 -TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAP 1102
             |||     ||.   |||.::.::.:...:.|.||...::||.:.:||||.||.....|......
Zfish  1199 GTLS-----PGM---VGLAVSHSLQVTGFLSWIVRSWTDVENNIVSVERVKEYADTPKEAAWSIE 1255

  Fly  1103 DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALF 1167
            ....|| :||:.|.|.|::..|:|...  .|..||.:|..|..|||:|||||||||||||...:|
Zfish  1256 GSSLPP-SWPQTGTIEFQDYGLQYRKG--LELALKGISVHIHEREKIGIVGRTGAGKSSLALGIF 1317

  Fly  1168 R-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEV 1231
            | |....|.:.||..:..::||||||.:|:||||:||||||::|.|||||:.||||::|..||..
Zfish  1318 RILEAAKGEIYIDGINIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALELA 1382

  Fly  1232 KLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQAT 1296
            .||..||:|||.|..:.||||.|.|:|||||||||||:||:.::||:|||||.:|.:||.|||:|
Zfish  1383 HLKNFVSELPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQST 1447

  Fly  1297 IRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            |||:|.||.||||||||:||:|..||:|||.|.|||..||..|:.|...  |:.:..::|
Zfish  1448 IRSQFEDCAVLTIAHRLNTIMDYTKVIVMDKGHVVEMDSPSNLIAKRGQ--FYYMCREAG 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	448/1340 (33%)
		ABC_membrane	171..437	CDD:294371	68/269 (25%)
		ABCC_MRP_domain1	499..699	CDD:213217	93/201 (46%)
		ABC_membrane	799..1045	CDD:294371	61/263 (23%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	129/221 (58%)
abcc6a	XP_009300481.1	MRP_assoc_pro	5..1506	CDD:188098	452/1360 (33%)
		ABC_membrane	317..584	CDD:279056	68/269 (25%)
		ABCC_MRP_domain1	630..831	CDD:213217	94/216 (44%)
		ABC_membrane	955..1218	CDD:279056	68/287 (24%)
		ABCC_MRP_domain2	1267..1487	CDD:213211	129/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660