DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)03659 and Abcb9

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	675	Identity:	168/675 - (24%)
Similarity:	308/675 - (45%)	Gaps:	110/675 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 YESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQ 770
            |.||..:.|:.||.:..:.|   .|..||.|               ......||:.:       :
Mouse   124 YISLAASFLLWGLLATVRPD---AEALEPGN---------------EGFHGEGGAPA-------E 163

  Fly   771 ESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDMES 835
            ::.|.:|.....|.:..   |||||..|..::....   |:.||.|:       .|......:..
Mouse   164 QASGATLQKLLSYTKPD---VAFLVAASFFLIVAAL---GETFLPYY-------TGRAIDSIVIQ 215

  Fly   836 KSMDVYKYTLIIILSVIMNLSSSFL------LFNIA-KKASIRLHNTIFNRVTRADMHFFSINKH 893
            ||||  ::|..:::..::.:.||..      :|.:. .:.:|||.|.:|..:...:..||..|:.
Mouse   216 KSMD--QFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRT 278

  Fly   894 GSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYL 958
            |.:::|.|.|.:.|.:::...:...::..:.:.|:::.:.:::..|.:.|.|...|...:.|:|.
Mouse   279 GDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYG 343

  Fly   959 KTSRDL-KRVE-AINRSPVYSHLAASLNGLTTIRAL-----DAQRVLEKEFDSYQ--DAHSSAFF 1014
            |..:.| |.|: |:.|:...:.  .:::.:.|:|:.     :|:..|.|....|:  ...::|:.
Mouse   344 KYYKRLSKEVQSALARASTTAE--ETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYM 406

  Fly  1015 MYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGL--------VITQAMGLIDMVQWGV 1071
            .|:..|..      .:.|:.:||:.........|..:...|        |:...|..:..|..|:
Mouse   407 SYVWGSGL------TLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGL 465

  Fly  1072 RQTAELENTMTAVERVVEYESIEP----EGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKA 1132
            .|      .:.|.|:|.|:...:|    :|.| |||..        :|.:.|:.:...|......
Mouse   466 MQ------GVGAAEKVFEFIDRQPTMVHDGSL-APDHL--------EGRVDFENVTFTYRTRPHT 515

  Fly  1133 ENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHD---LRR 1193
            : ||:::||.:.|.:...:||.:|:||||.:|.|... ....|.||:   |.:.:|.:|   |.|
Mouse   516 Q-VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLL---DGKPIGAYDHKYLHR 576

  Fly  1194 QISIIPQEPVLFSGTMRYNLD------PFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGG 1252
            .||::.||||||:.::..|:.      ||     |.:....::......:.:|.||.:::..|.|
Mouse   577 VISLVSQEPVLFARSITDNISYGLPTVPF-----EMVVEAAQKANAHGFIMELQDGYSTETGEKG 636

  Fly  1253 TNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTII 1317
            ...|.||:|.|.:|||::|...:|::||||:.:|.:::.|||..|....:..|||.|||||.|:.
Mouse   637 AQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVE 701

  Fly  1318 DSDKVMVMDAGRVVEFGSPYELMTK 1342
            .:..::|:|.||||:.|:..:|:.:
Mouse   702 RAHLIVVLDKGRVVQQGTHQQLLAQ 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	168/675 (25%)
		ABC_membrane	171..437	CDD:294371
		ABCC_MRP_domain1	499..699	CDD:213217
		ABC_membrane	799..1045	CDD:294371	51/261 (20%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	77/230 (33%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	168/675 (25%)
		ABC_membrane	189..451	CDD:279056	53/281 (19%)
		ABCC_TAP	489..714	CDD:213215	78/242 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000