DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Abcb10

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	656	Identity:	166/656 - (25%)
Similarity:	283/656 - (43%)	Gaps:	118/656 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 SSSGKEHV------ERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818
            :::|:..|      .|.|.|.:|.|            |.||.:  |||:...|    .:||...:
Mouse   115 AATGRSEVWKLLGLVRPERGRLSAA------------VGFLAV--SSVITMSA----PFFLGRII 161

  Fly   819 KKEST--AAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVT 881
            ....|  :.|:|     :|.:......|.:.:.....|....:|:.:..:....||..::|:.:.
Mouse   162 DVIYTNPSEGYG-----DSLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSIL 221

  Fly   882 RADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNP------LLL 940
            |.::.||...:.|.::||.:.|.:.:...:...|.|.::.....:..:.::..|:|      |.:
Mouse   222 RQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSV 286

  Fly   941 VPTLMLSVIFY--HLRNLYLKTSRDLKRVEAINRSPVYSHLAAS-LNGLTTIRALDAQRVLEKEF 1002
            ||.:.:..:.|  :||.|...|...|  .||       :.||.. :..:.||||...:..   |.
Mouse   287 VPPISVLAVIYGRYLRKLSKATQDSL--AEA-------TQLAEERIGNIRTIRAFGKEMT---EV 339

  Fly  1003 DSY------------QDAHSSAFFMYISTSQAFGYCMNCI--CVIYISIITL-----------SF 1042
            :.|            ::|.:.|.|.     .|.|...|.|  .|:|...:.:           ||
Mouse   340 EKYTGRVDQLLQLAQKEALARAGFF-----GAAGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSF 399

  Fly  1043 FAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEP-----EGMLEAP 1102
            ..:....|..:|       ||....       :||...:.|..|:.|....:|     |||:
Mouse   400 LMYAFWVGLSIG-------GLSSFY-------SELMKGLGAGGRLWELLERQPRLPFNEGMV--- 447

  Fly  1103 DDKKPPKTWPEQGEIIFKELNLRYTPNAKAE-NVLKSLSFVIQPREKVGIVGRTGAGKSSLINAL 1166
               ...||:  ||.:.|:  |:.:|..|:.| :|.:..|..|.......:||.:|:|||::::.|
Mouse   448 ---LDEKTF--QGALEFR--NVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLL 505

  Fly  1167 FRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFS----GTMRYNLDPFDEYSDEKLWG 1226
            .|| ....|:|.:|..|.||:....||.:|..:.|||||||    ..:.|..|.....:.:::..
Mouse   506 LRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVER 570

  Fly  1227 CLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDG 1291
            ..|.....|.:...|.|..:.:.|.|...|.||:|.:.:|||:|:..:||::||||:.:|.:.:.
Mouse   571 AAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEH 635

  Fly  1292 LIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            |:|..:.......|||.|||||.||.:::.|.|:|.|::.|.|:..||:.|.:. ::..|:|:..
Mouse   636 LVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNG-LYRKLMNKQS 699

  Fly  1357 RASYEG 1362
            ..||.|
Mouse   700 FLSYNG 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	160/635 (25%)
		ABC_membrane	171..437	CDD:294371
		ABCC_MRP_domain1	499..699	CDD:213217
		ABC_membrane	799..1045	CDD:294371	57/281 (20%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	75/226 (33%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	161/643 (25%)
		ABC_membrane	142..403	CDD:279056	59/288 (20%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	79/242 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000