DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc9

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_005164758.1	Gene:	abcc9 / 561160	ZFINID:	ZDB-GENE-050517-23	Length:	1583	Species:	Danio rerio

Alignment Length:	1420	Identity:	419/1420 - (29%)
Similarity:	703/1420 - (49%)	Gaps:	238/1420 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGN------------RLCASWERELK 147
            |.:|...:|:..|:....::         ||:|.:|   :|.            ||..|:|.:.:
Zfish   223 NLLSKATYWWMNPLIIGAHK---------RPIELKK---IGKLPIAMRALTNYLRLKDSYEEQRQ 275

  Fly   148 N---DGRSPSLVRALLRVFGWQ-------------LGFPGLAIFVVELGLRTLQPIFLVKLISYF 196
            |   ..:|||:.:::.|.||..             |||.|              |:.:..::.:.
Zfish   276 NTEDPEKSPSIWKSMYRAFGGSILLSSTFRYMADLLGFAG--------------PLCISGIVEHL 326

  Fly   197 --SGEPDAANA------GFYYAVAQIVI---SALTVM----ILTPTTF-----------GIHHVC 235
              |.|.|..|.      |.|:..:..::   |.|.|:    ::...||           ||:
Zfish   327 HNSTEIDRTNKTGNMTFGVYFMSSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGIN--- 388

  Fly   236 FKMRVAMGSMIFRKALRLTKG--ALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVIT 298
              :|.|:.:||:.|.|||:..  ::|:.|.|.:.||::.:..:|....:....||..|:|:::..
Zfish   389 --LRGALLAMIYNKILRLSTSNMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGV 451

  Fly   299 YLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAW 363
            .|:|..:|.||:.|...:||..|:|..:.|:.:.||....:.:.:|::...||:..|::||:|||
Zfish   452 ILLYYLLGNSALIGAGVILLLAPVQYLIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAW 516

  Fly   364 EQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGK-VFTPEIAFMIT 427
            |..|...|...|.||:.:::...............:...|:..:.|.:..:.: ..:|..||...
Zfish   517 ENIFCDRVEETRGKELTSLKTFALHTSMSIFMNAAIPIAAVLATFVTHAYIEEDRLSPAKAFASL 581

  Fly   428 AYYNVLLAAMSIYVPSAIIQTA-QFLTSIRRVEQFMQSEELGSSD----------------KSEG 475
            |.:::|:.  .:::.|.:::.| :.|.|::::.:|:||:|:|...                |.:|
Zfish   582 ALFHILVT--PLFLLSTVVRFAVKALVSVQKLSEFLQSDEIGDDSWRNGDMCMSLEVGKKYKYQG 644

  Fly   476 PSKD-TVPGNPPSNNNEADLLKS---------AISIRDLKAKWDPNSPDYTLSGINLEIKPGSVV 530
            .:|. ...|....:|.|..:.:.         |:.:.|....|..|..  |||.||:.|..|.:.
Zfish   645 DTKAINRKGRYRMDNYEQPVRRQLRPSETEDVAVQVNDGFFTWGSNLS--TLSDINIRIPTGQLT 707

  Fly   531 AVIGLTGSGKSSLIQAILGELKANSGQL--------------QVNG---------------SLSY 566
            .::|..|.|||||:.|:|||::..||::              .::|               |::|
Zfish   708 MIVGQVGCGKSSLLLAMLGEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAY 772

  Fly   567 TSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKAR 631
            .:|:|||.:.||.:||.||.|.:.|||:.|:..|:|:.|.||||..|.|.:||||..|||||:.|
Zfish   773 ATQKSWLLNATVEENITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQR 837

  Fly   632 ISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVDQIVI 694
            |.:||::|:..:|..||||.||:|..::.||..:.:...|:..  |||||||:.|:|.|.|.|:.
Zfish   838 ICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIA 902

  Fly   695 LANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNE-------VTPIKEN 752
            :.:|         |:|:.|.:..:    :|...:..|.....:|..|.:.|       .|.::..
Zfish   903 MKDG---------SVLREGTLKDI----QTHDVELYEHWKTLMNRQDQELEKDTDLESQTTLERK 954

  Fly   753 SEQTVGGSSSGKEH---------VERQESGGISLALYRK----------YFQAGGGLVAFLVMLS 798
            :.:....|...|.|         ||.::...:|....|:          |..:||.|:.|| |:|
Zfish   955 TLRRAFYSREAKNHVDDEDEEEEVEEEDDDNMSTTTSRRSKIPWKMCCCYLSSGGFLMVFL-MVS 1018

  Fly   799 SSVLAQVAVTGGDYFLTYWVKKE-------STAAGHGEMED----MESKSMDVYKYTLIII---- 848
            |.:.....:...||:|..|....       :::..|...:|    .|.:|   |....||:
Zfish  1019 SKLAKHSVMVAIDYWLAAWTSSNPHNQSFVNSSFNHTLNDDATQIAEHRS---YVPVFIILCAAA 1080

  Fly   849 --LSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVL 911
              |.:|.:|:..||  .:|  |:..||:.:.|::..|.:.||.:...|.|||||:.|.:.:|:.:
Zfish  1081 IALCLITSLTVEFL--GVA--AATNLHHNLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHI 1141

  Fly   912 PVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVY 976
            |..|..:.:..|.....|.|||.|.|..|:..:.|:|.||.::..:...|:||:.::...:.|:.
Zfish  1142 PPTLESLTRSTLLCLSAIGVIAFVTPAFLIALVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLL 1206

  Fly   977 SHLAASLNGLTTIRALD-----AQRVLEKEFDSYQDAHSSAFFMYISTSQAF-----GYCMNCIC 1031
            .|.:.:..|||||||..     .||:||     ..|.:::| ::::|.:..:     .| :..:.
Zfish  1207 CHFSETAEGLTTIRAFRHEARFKQRMLE-----LTDTNNTA-YLFLSAANRWLEVRTDY-LGAVI 1264

  Fly  1032 VIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPE 1096
            |:..::..: :...|.|.   |||.:|.|:.|.:.:.|.||..|:||..|.||::|..:.|.|.|
Zfish  1265 VLTAAVAAI-WSTSPSGL---VGLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESE 1325

  Fly  1097 GMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSS 1161
            ....:.|..:.|:.||:.|||...:|.:||  ::..:.|||.::..|.|.:||||.||||:||||
Zfish  1326 NYEGSMDVSQVPEDWPQHGEITIHDLCVRY--DSMLKPVLKHVNAHINPGQKVGICGRTGSGKSS 1388

  Fly  1162 LINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLW 1225
            |..|.|.: ...:|.::||..|..::.|..||.::|||.|:||||||::|.||||....:|::||
Zfish  1389 LSLAFFNMVDVFEGKIVIDGIDICKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLW 1453

  Fly  1226 GCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1290
            ..||..:||.:|..||.||.:.::|||.|||||||||.|||||.:|::.||:||||||::|..|:
Zfish  1454 EALEIAQLKNMVKALPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1518

  Fly  1291 GLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS 1345
            .::|..:.:.|.|.||:||||.:.:|:::::|:|..:|.:||..|...|:.:.||
Zfish  1519 NILQKVVMTAFADRTVVTIAHLVSSILEAEQVLVFSSGILVENDSAINLLAQEDS 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	417/1416 (29%)
		ABC_membrane	171..437	CDD:294371	68/294 (23%)
		ABCC_MRP_domain1	499..699	CDD:213217	87/230 (38%)
		ABC_membrane	799..1045	CDD:294371	68/272 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	103/221 (47%)
abcc9	XP_005164758.1	CFTR_protein	223..1575	CDD:273530	419/1420 (30%)
		ABC_membrane	304..591	CDD:294371	71/307 (23%)
		ABCC_SUR1_N	678..907	CDD:213257	88/239 (37%)
		ABC_membrane	1045..1300	CDD:294371	72/272 (26%)
		ABCC_SUR2	1269..1583	CDD:213255	132/311 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650