DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc13

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_017209479.1	Gene:	abcc13 / 559093	ZFINID:	ZDB-GENE-050517-26	Length:	1020	Species:	Danio rerio

Alignment Length:	1311	Identity:	286/1311 - (21%)
Similarity:	495/1311 - (37%)	Gaps:	372/1311 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SNFISSLCF-----WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKN----- 148
            :.|.:..||     .|.:.:...|:|..|...||.:...|.....|.:.....||::..|
Zfish    10 TRFGTLYCFQTSPVLYNMRMVVMGHRGPLQLFDLLKLYNEDSVHTLCSVFDHEWEKQQNNYKERS 74

  Fly   149 -----DGRSPSLVR-------ALLRVFGWQLGFPGLAIFVVELGLRT-----LQPIFLVKLISYF 196
                 .||...||.       :||... |:...|.| |.:|.|.|.:     |.||.:..:|.:.
Zfish    75 DLEDDSGRKSLLVTSKTNAGYSLLYTL-WKTFHPSL-IKIVLLRLSSDLFSILVPITIRWVILFS 137

  Fly   197 SGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRV-------AMGSMIFR--KALR 252
            ..:......|:.||:  :|..||..     ..|..||...:.|:       .:...::|  |.|.
Zfish   138 ERQAMFGWTGYTYAL--VVFGALCC-----GAFSQHHFEKRSRIITANAHAILSGTVYRKIKTLS 195

  Fly   253 LTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFML 317
            |:..:...:.:.|..::: .:..|:.....|:..:|..||:|.:...|::.::|.|.:.||..:|
Zfish   196 LSHSSRWHSDTSHREDML-GEAERVAELVVTLACIWSSPLRVTLYLGLLWAKLGPSVLVGVTLLL 259

  Fly   318 LFMPIQMYLGTRTSAIQLKAAE--RTDNRIR-----MVNEIISAIQVLKMYAWEQPFEQMVTHAR 375
            :.:|::       ||::.||.:  ||...||     ::.|::...|.||:..||..|.|.||.:|
Zfish   260 VLIPVK-------SAVERKAKQLRRTHRVIREKSEQLIKEMLHKYQALKLLTWESWFFQRVTESR 317

  Fly   376 EKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL--GKVFTPEIAFMITAYYNVLLAAMS 438
            .:|:..:|...::..|.....|.:..:.||.||..:|::  |.|.|....|....::.:|
Zfish   318 TRELEMLRIQGFLTAFSMLDSICMPFLVIFSSLGAFVLVDDGNVLTSSQIFTSVCFFRLL----- 377

  Fly   439 IYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRD 503
                                                         .||
Zfish   378 ---------------------------------------------RPP----------------- 380

  Fly   504 LKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTS 568
                                     ::..:||.    |.|.||
Zfish   381 -------------------------LLEFLGLF----SVLKQA---------------------- 394

  Fly   569 QESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARIS 633
            |:|:                           |.||:
Zfish   395 QQSF---------------------------CYLEK----------------------------- 403

  Fly   634 LARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANG 698
                      |:|.:|
Zfish   404 ----------IFLTED------------------------------------------------- 409

  Fly   699 QIKALGDYESLLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSG 763
                               ||:.....|..|||      :|.|:..:  |..|..|:. ..|...
Zfish   410 -------------------LGTSQFLTKGATEE------SSADSTQQ--PCDECQEKQ-NDSDEK 446

  Fly   764 KEHVERQESGGISLALYRKYFQAGGGLVAFLVMLS--SSVLAQVAVTGGDYFLTYWVKKESTAAG 826
            ::|...:.....:..||...|......|..||.||  :..|||      |..|..|..:.....|
Zfish   447 RDHYHFRNEFREACWLYLGAFGWHWVSVCSLVYLSVCAVSLAQ------DGVLCMWTGEAKEVQG 505

  Fly   827 HGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSIN 891
            ....:::.:..:..  |.|:.:|...:...:::.|...:.|||..||..:.:.|....:|...:|
Zfish   506 LDGWKELRNSRLSA--YALLGLLQAFLVCCAAYCLTCGSLKASRTLHTELLSDVLHLPVHSQKMN 568

  Fly   892 KHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNL 956
            .. .::...|:||..:||.||..|..:::..|.:...|.:|:.:.|:..:....:.::..|:::.
Zfish   569 TR-KLMQALTQDMQVIDEELPKHLHSILKSLLDVLSTITLISFIIPVFSLAVCPMIILLLHIQSR 632

  Fly   957 YLKTSRDLKRVEAINRSPVYSHLA-------ASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAF- 1013
            ...|...::.:|| |.:...:.||       |||:| ...||:..:..|:            ||
Zfish   633 ISSTHMQIRNMEA-NPAVSLTSLARVTQCAEASLSG-PEHRAVCLKHCLQ------------AFT 683

  Fly  1014 ------FMYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVR 1072
                  :..|:|........:.:..|.:.:::|......|.:|. |.|.:..:..:.:.:.:..:
Zfish   684 QNLLLKYNTINTESWVVLWFDGVAGIVLLLVSLILLQTQPESGL-VALTLICSFNIKEALHYCPQ 747

  Fly  1073 QTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAEN--V 1135
            ..:.:...|.:::.:  ::|.:.|...|...:.:||..||:.||:.|:    .|...|.::.  .
Zfish   748 AASVITTDMLSLQNL--FDSAKAEKEAEWTVNYRPPYDWPQHGEVKFR----NYESEASSDGTPA 806

  Fly  1136 LKSLSFVIQPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIP 1199
            |:.:...|...||:|:|.|.......|||:||| :....|::|||..:..:|||||||.::.||.
Zfish   807 LRGVHLTILKGEKIGVVSRQKTDTDVLINSLFRSVEARSGALLIDNINISRMGLHDLRGRLQIIS 871

  Fly  1200 QEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVC 1264
            |.||||||.:|.|||||.|:||.::|..||...|||.|..:|..|...:......||.|||:|:|
Zfish   872 QVPVLFSGPLRANLDPFAEHSDAQVWLALELCHLKESVQQMPAQLLHPVQRTALAFSFGQRRLLC 936

  Fly  1265 LARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGR 1329
            ||||:|...|||:::|...:|||:|:.|:|..|.::|:|||||.::....:::.:|:|:|:|.|:
Zfish   937 LARALLARVRILLVEEPLHHVDPETEDLLQQVIHAEFKDCTVLFLSQNPLSVLHTDRVLVLDKGQ 1001

  Fly  1330 VVEFGSPYELM 1340
            .|:|.:|..|:
Zfish  1002 AVKFDAPSTLL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	286/1311 (22%)
		ABC_membrane	171..437	CDD:294371	70/288 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	14/199 (7%)
		ABC_membrane	799..1045	CDD:294371	51/259 (20%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	92/223 (41%)
abcc13	XP_017209479.1	SunT	29..>409	CDD:331423	103/580 (18%)
abcc13	XP_017209479.1	SunT	<461..1018	CDD:331423	165/582 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750