DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and cftr

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001038348.1	Gene:	cftr / 559080	ZFINID:	ZDB-GENE-050517-20	Length:	1485	Species:	Danio rerio

Alignment Length:	1514	Identity:	419/1514 - (27%)
Similarity:	717/1514 - (47%)	Gaps:	263/1514 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDG 150
            :..:|...:|.:|...||:|.||.|||:::.|..:|:|:...:..:|||..||...|:||:.:..
Zfish     1 MQRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGK 65

  Fly   151 RSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYF--SGEPDAANAGFYYAVAQ 213
            :.|||:||:.|.:.......|..:::.| ..:|:||..|.::|:.|  :.||:.|| |::.|...
Zfish    66 KKPSLLRAMARCYIKPFLLFGFLLYIGE-ATKTVQPQLLGRIIASFDPAHEPERAN-GYFLAFGL 128

  Fly   214 IVISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLD 278
            .::.....::|.|..||:||:..::|:|:.|:|::|.|:|:...|...::|.:|:|:|.::.:.|
Zfish   129 GLLFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFD 193

  Fly   279 SAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDN 343
            .:....|::|:.|||.::.|.|:::.|.:::...:..:.|...:|.:|..:....:.:....|:.
Zfish   194 QSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKVLLTNK 258

  Fly   344 RIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSL 408
            |:.:.:||:..:..:|.|.||:..|.::.:.|:.|:...|:...:|.| ::.....|.:.:.::.
Zfish   259 RLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYF-YSSAYFFSAIFVIVAA 322

  Fly   409 VGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKS 473
            |....|.:.......|...:|..||...::..:|.:|......:..|.::|:|:..||.
Zfish   323 VVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRLIWKIEEFLSKEEY------ 381

  Fly   474 EGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDY----------------------- 515
                          ...|.||..:.:.::|:.|.||....:.
Zfish   382 --------------KLMEYDLSITELELQDVTASWDEGPGELLERIKQENKANGHHNGDAGLFFT 432

  Fly   516 ------TLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLF 574
                  .|..|:|::|.|.::||.|..|||||||:..|||||..:||:::.:|.:||:||.:|:.
Zfish   433 NLYVAPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISYSSQTAWIM 497

  Fly   575 SGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVY 639
            .||:|.|||||...|..||:.|||.|.||.|...||.:|.|.:.|.|..||||||||::|||:||
Zfish   498 PGTIRDNILFGLTYDEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALARAVY 562

  Fly   640 RKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALG 704
            |.|.:||||.|.:.:|.:..:.:||:|:...:...|.:|||::.:.|...|:|::|.||:....|
Zfish   563 RDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESFFYG 627

  Fly   705 ----------DYESLL------------------------------------------------- 710
                      |:.|||
Zfish   628 TFPELQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQPERSAFRQVPPTKPM 692

  Fly   711 -----KTGLITG-LGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGS--------- 760
                 |..:|.. ||...|....:..|:| :....||.|..:.|..|..:::..||
Zfish   693 YIDERKASVIVNPLGVARKASFIQVPEEE-VRRTLPDRKFSLVPENELVDESFMGSDVYHNHGVH 756

  Fly   761 ------------------SSGKEHVERQ-----------------------------------ES 772
                              ...:||::..                                   |.
Zfish   757 MAGQRRQSVLAFMTNAQGQGRREHLQSSFRRRLSVVPQSELASELDIYTRRLSDSTYDMTGILEE 821

  Fly   773 GGISLAL------------------YRKYFQAGGGLVAFLVMLSSSVLAQVAVTG---GDYFLT- 815
            ..|...|                  |.:|......|:..|:.:  ..:|.:.:.|   |.:.:|
Zfish   822 ENIEACLTDEIDEIEETFETTKWNTYVRYVSNNKSLLYVLIFI--LFIAAIEIAGSVAGIFLITD 884

  Fly   816 -YWVKKESTAAGHGEMEDMESKSMDVYKYTL-----IIILSVIMNLSSSFL-------------L 861
             .|.::...:..:.......|.|...|..|:     ..||.:.:..|.|.|             .
Zfish   885 ELWREEHQRSEPNMTKHSNASSSGQTYAITVTPTSSYYILYIYVATSESLLAMGFFRGLPFVHTT 949

  Fly   862 FNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLA 926
            ..|:||    ||..:.:.|..|.|...:..|.|.|:|||||||:.:|::||:::.|.:|:.:.:.
Zfish   950 ITISKK----LHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVV 1010

  Fly   927 GIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRA 991
            |.|:|::.|.|.:.:....|::||..:|..:|:|.:.||::|...|||::|||..||.||.||||
Zfish  1011 GCILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLKGLWTIRA 1075

  Fly   992 LDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYISI---ITLSFFAFPPGNGADV 1053
            .:.|...|..|....:.|::.:|:|:||.:.|.:..:.:.|.:.::   |.:......||   ::
Zfish  1076 FERQAYFEALFHKTLNTHTATWFLYLSTLRWFLFRADILFVFFFTLAAWIAVGTNQDKPG---EI 1137

  Fly  1054 GLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPD------------DKK 1106
            |::|..||.::...||.|..:..::..|.:|:||.::..:..|  ...||            |.:
Zfish  1138 GIIICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSE--TPKPDKGKDSDLIIENVDAQ 1200

  Fly  1107 PPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSY 1171
            ...:||.:|:|..:.|.::||....|  |||:|||..:.|::|||:||||:|||||.|||.:|.|
Zfish  1201 ADSSWPHRGQIEVRNLTVKYTEAGHA--VLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLVY 1263

  Fly  1172 TDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEV 1236
            |||.:.||..:..:|.|...|:...::||:..:|:|.:|.||||:..:|||:||...|||.||.|
Zfish  1264 TDGEISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTV 1328

  Fly  1237 VSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKF 1301
            :...||.|..::..||...|.|.:||:||||:||...|||::||.:|::||.|..:::.|:|..|
Zfish  1329 IEQFPDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKKTLRQSF 1393

  Fly  1302 RDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS-----------KVFHNLVNQS 1355
            ..||:|...|::..:::....::||.|:|..:.|..:|:.::..           |:|... |.|
Zfish  1394 STCTILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLLNETSHLKQAISPAERLKLFPRR-NSS 1457

  Fly  1356 GRASYEGLLKIAQETFESS 1374
            .|.....|..:.|...|.:
Zfish  1458 MRTPQSKLSSVTQTLQEEA 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	411/1467 (28%)
		ABC_membrane	171..437	CDD:294371	65/267 (24%)
		ABCC_MRP_domain1	499..699	CDD:213217	89/228 (39%)
		ABC_membrane	799..1045	CDD:294371	76/271 (28%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	93/220 (42%)
cftr	NP_001038348.1	AAA	1..1485	CDD:333001	419/1514 (28%)
		Disordered R region. /evidence=ECO:0000250\|UniProtKB:P13569	653..826		18/173 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1452..1485		6/26 (23%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P13569	1483..1485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586108
Domainoid	1	1.000	55	1.000	Domainoid score	I11111
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850