DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc10

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	XP_005155817.1	Gene:	abcc10 / 556709	ZFINID:	ZDB-GENE-050517-24	Length:	1548	Species:	Danio rerio

Alignment Length:	1437	Identity:	454/1437 - (31%)
Similarity:	708/1437 - (49%)	Gaps:	211/1437 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 HRNKDESLSVNT---SPPLVCRKCFELGHQTENCKQKLTVNSENNSAQNEKEKVLPENPRARSNF 96
            :|.:.:.||.|.   :|.:|..:.||          ::||..:.                  |:.
Zfish   197 YRTQRDLLSCNAEDEAPLIVTFEPFE----------EVTVAEDG------------------SSL 233

  Fly    97 ISSLCFWYTIPIFRKGYR------------------------------KTLDSTDLYRP------ 125
            :|.|.:.:..|:..:|.|                              |.|.|..|.||
Zfish   234 LSRLLYLWLNPLLNRGKRGELGRPSDVFELPSRLRTKSVTRRFYQCWEKCLHSRALERPERPDRR 298

  Fly   126 ----LEEQK-SDILGNRLC-ASWERELKNDGRSPSLVRALLRVFG---WQLGFPGLAIFVVELGL 181
                |::.. |:....|:| ...|.|:|       |::.|.:.||   :.||  ||.:  |...|
Zfish   299 PRGNLQDNSWSEAQPERICEGEAEHEVK-------LLQVLHKAFGLRYYLLG--GLKL--VASML 352

  Fly   182 RTLQPIFLVKLISYFSGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGSMI 246
            ....|:.|..|:.:...|....:.|.:.||.....:.|..::.....:.:..|..:.|.|:.|.|
Zfish   353 AFAGPLLLGGLVGFMETEGAPLSKGVWCAVGLFASTFLAALLKNIFVYEVSKVALEARAAVISTI 417

  Fly   247 FRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVF 311
            :.|||::...:|.....|.|||.:|.|..|:.:...:.|.:|..|.|.::..||:|.::|::.:.
Zfish   418 YCKALKVNAPSLARFNMGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYLQVGVAFLG 482

  Fly   312 GVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHARE 376
            ||...:|.:|:...|.:|.........:..|.|::::.||:..|:|||.|.||:.|.|.:..||:
Zfish   483 GVGVAVLLVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHFTQKIEEARK 547

  Fly   377 KEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYV 441
            ||::.::..:|:..........|..|...|:.:.||:||...|....|...|...:|:..::.:
Zfish   548 KELHHLKLLKYLDAVCVYTWAALPVVISILTFITYVLLGNNLTAAKVFSTLALVGMLILPLNAF- 611

  Fly   442 PSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPS------------NNNEADL 494
            |..:..|.:...|:.|:::|:..::   .|.|...|: ..|.:|||            .:.|||
Zfish   612 PWVLNGTLEAKVSLDRIQRFLAVQD---QDLSVYYSQ-VCPEDPPSAVQMVQASFSWKQSEEAD- 671

  Fly   495 LKSAISI-RDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQL 558
               ::|| .|:..:..|....| |..:||.:|.||:|.|:|..|.|||||:.||.|||....|::
Zfish   672 ---SVSIPDDITEEGSPPRSFY-LHALNLNVKMGSLVVVVGKVGCGKSSLLAAITGELTRCGGEV 732

  Fly   559 QVNG---SLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGER 620
            .|.|   ......||.|:...||:.|||||:..|:..|:.|::.|||..|.::||..|.|.|||.
Zfish   733 FVQGREQGFGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADDLNILPGGDQTEVGEN 797

  Fly   621 GATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQF 685
            |.|||||||:|::|||:||....||||||||:||||.||.||.::|:.|.|:..|.:|.||:.:|
Zfish   798 GVTLSGGQKSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGILKDKTRILCTHRIEF 862

  Fly   686 LPHVDQIVILANGQIKALGDYESLLKTGLITGLGSLSKTDKAKTEE---QEPLNLNSPDNKNEVT 747
            :...|.:|::.||.|...|....:|  .|:.|......:..||.::   .|.:..:.|:.|.|:.
Zfish   863 VDKADVVVLMDNGMIVKTGAPSEVL--SLVKGPKDSKNSSNAKEKDSAGSEEMEASEPELKAELE 925

  Fly   748 PIKENSEQTVGGSSSGKEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDY 812
            ...|                |:::.|.:|.|:||.|::|.||.:|..|:| :..|.|.:....|:
Zfish   926 MFGE----------------EQKQMGTLSWAVYRSYWKAVGGCMAVAVLL-ALFLMQASKNVSDW 973

  Fly   813 FLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIM-----------------NLSSSFL 860
            :|::|:         ..|:|..::.:.| ..|.:::||.:.                 |:||. |
Zfish   974 WLSHWI---------SHMKDNMTELVSV-SATPLLMLSFLSPGRLVFNAPARGSESSGNMSSE-L 1027

  Fly   861 LFNIAKKASIRLHNTIF------------------------NRVTRADMHFFSINKHGSILNRFT 901
            .|.:....|:...||:|                        :.|.:|.|.||.....|.|||||:
Zfish  1028 KFYMTVYGSLAAANTVFTAARAFLFAYGAICAATVVHKRLLSSVLKATMTFFDTTPLGRILNRFS 1092

  Fly   902 KDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKR 966
            .|:..||:.||.||..::.....|.|::||::...|.:|:|.:.|..::|..:..|..:||:|||
Zfish  1093 SDIYSVDDSLPFVLNILLANVFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQCFYRYSSRELKR 1157

  Fly   967 VEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCIC 1031
            :.::..||||||.:.:|:||:|:|........|:|.:...:.:....|...:..|.....:..|.
Zfish  1158 LCSLTLSPVYSHFSETLSGLSTVRGSGHTTRFEEENERRLEQNQRCLFNSNAAMQWLDIRLQMIA 1222

  Fly  1032 VI------YISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY 1090
            |.      .|::|.....:..||.   |||.::.|:.:.:::...:...|:.|..:.::||..||
Zfish  1223 VTVVTGISVIAVIQHQLKSIDPGL---VGLSLSYALSITNLLSGLIFSYAQTEMQLVSIERTEEY 1284

  Fly  1091 ESIEP----EGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGI 1151
            .:..|    :..||..|      .|||:..:.|.::.|.|.|.  ..|.|..:|..:.|.||:||
Zfish  1285 STSIPQEPQQASLEVLD------RWPERARVEFVDVVLSYRPG--LPNALDGVSVEVLPGEKIGI 1341

  Fly  1152 VGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDP 1215
            |||||:|||||..||||: ....|.:|:|..|...:.|.|||.:::||||:|.|||.::|.||||
Zfish  1342 VGRTGSGKSSLFLALFRMVELNQGQILLDGVDISSVRLSDLRSKLAIIPQDPFLFSSSVRENLDP 1406

  Fly  1216 FDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1280
            ...:.|.:|...||:..|..|| ....||.|::.|.|.:.|||||||:|||||:|.|..||.:||
Zfish  1407 HGRHPDYRLLEALEQCHLGNVV-QRNGGLDSEVGERGKSLSVGQRQLLCLARALLTEANILCIDE 1470

  Fly  1281 ATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS 1345
            |||:||.:||.|:|.|||.||:|.|||||||||:||:|||||:||.||:||||.||..|..:.||
Zfish  1471 ATASVDQKTDMLLQKTIREKFKDKTVLTIAHRLNTIMDSDKVLVMHAGKVVEFDSPATLCQREDS 1535

  Fly  1346 KVFHNLV 1352
             .|..|:
Zfish  1536 -AFQKLL 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	440/1369 (32%)
		ABC_membrane	171..437	CDD:294371	71/265 (27%)
		ABCC_MRP_domain1	499..699	CDD:213217	93/203 (46%)
		ABC_membrane	799..1045	CDD:294371	72/292 (25%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	116/221 (52%)
abcc10	XP_005155817.1	SunT	248..1531	CDD:331423	436/1345 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650