Protein Alignment l(2)03659 and ABCC1

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: XP_047290087.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1584
• Species: Homo sapiens
• Alignment Length: 1384
• Identity: 447/1384 - (32%)
• Similarity: 738/1384 - (53%)
• Gaps: 180/1384 - (13%)

  Fly    90 PRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWEREL-------- 146
            |.:.::|:|.:.||:...:..:|||:.|:.:||:...:|..|:.:...|..:|::|.
Human   262 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 326

  Fly   147 ----------------KNDGR---------------SPSLVRALLRVFGWQLGFPGLAIFVVELG 180
                            |.|..               :|||.:.|.:.||        ..|::...
Human   327 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFG--------PYFLMSFF 383

  Fly   181 LRTLQPIF------LVKLISYFSGEPDAAN-AGFYYAVAQIVISALTVMILTPTTFGIH---HVC 235
            .:.:..:.      ::||:..|..:..|.: .|::|.|...|.:.|..::|       |   |:|
Human   384 FKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVL-------HQYFHIC 441

  Fly   236 F----KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPR-LDSAPYTVHYLWVGPLQVL 295
            |    :::.|:...::||||.:|..|...:|.|.:|||:|.|..| :|.|.| ::.:|..||||:
Human   442 FVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 505

  Fly   296 VITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKM 360
            :..||::..:|.|.:.||..|:|.:|:...:..:|...|:...:..||||:::|||::.|:|||:
Human   506 LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKL 570

  Fly   361 YAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVIL--GKVFTPEIA 423
            ||||..|:..|...|::|:..:::..|:........:....:....:...||.:  ..:...:.|
Human   571 YAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTA 635

  Fly   424 FMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSN 488
            |:..|.:|:|...::| :|..|....|...|::|:..|:..|||........|.||....|
Human   636 FVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---- 695

  Fly   489 NNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKA 553
                     :|::|:....|..:.|. ||:||...|..|::|||:|..|.|||||:.|:|.|:..
Human   696 ---------SITVRNATFTWARSDPP-TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDK 750

  Fly   554 NSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVG 618
            ..|.:.:.||::|..|::|:.:.::|:|||||..::...|..|::.|||..|.::||..|.|.:|
Human   751 VEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIG 815

  Fly   619 ERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTH 681
            |:|..||||||.|:||||:||..|.|||.|||||||||.|.:|:|:..:  :|.|:..|.:||||
Human   816 EKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTH 880

  Fly   682 QEQFLPHVDQIVILANGQIKALGDYESLLK--------------------------TGLITGLGS 720
            ...:||.||.|::::.|:|..:|.|:.||.                          || ::|.|.
Human   881 SMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTG-VSGPGK 944

  Fly   721 LSK--------TDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKE------HVERQE 771
            .:|        ||.|..:.|..|: :|.....:::. ..||...:..:.:.||      ..::.:
Human   945 EAKQMENGMLVTDSAGKQLQRQLS-SSSSYSGDISR-HHNSTAELQKAEAKKEETWKLMEADKAQ 1007

  Fly   772 SGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDME-- 834
            :|.:.|::|..|.:|.|..::|| .:...:...|:....:|:|:.|......   :|..|..:
Human  1008 TGQVKLSVYWDYMKAIGLFISFL-SIFLFMCNHVSALASNYWLSLWTDDPIV---NGTQEHTKVR 1068

  Fly   835 ---------SKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSI 890
                     |:.:.|:.|::.:.:..|:              ||..||..:.:.:.|:.|.||..
Human  1069 LSVYGALGISQGIAVFGYSMAVSIGGIL--------------ASRCLHVDLLHSILRSPMSFFER 1119

  Fly   891 NKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRN 955
            ...|:::|||:|::..||.::|.|:...|.....:.|..|||....|:..:....|.:|::.::.
Human  1120 TPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQR 1184

  Fly   956 LYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTS 1020
            .|:.:||.|||:|:::|||||||...:|.|::.|||.:.|.....:.|...|.:..|::..|..:
Human  1185 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1249

  Fly  1021 QAFGYCMNCI--CVIYISII--TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTM 1081
            :.....:.|:  |::..:.:  .:|..:...|.   |||.::.::.:...:.|.||.::|:|..:
Human  1250 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGL---VGLSVSYSLQVTTYLNWLVRMSSEMETNI 1311

  Fly  1082 TAVERVVEYESIEPEGMLEAP---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
            .||||:.||...|.    |||   .:..||.:||:.|.:.|:...|||..:  .:.||:.::..|
Human  1312 VAVERLKEYSETEK----EAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED--LDFVLRHINVTI 1370

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFRLSYT-DGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            ...||||||||||||||||...|||::.: :|.::||..:..::||||||.:|:||||:||||||
Human  1371 NGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSG 1435

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRE 1272
            ::|.|||||.:||||::|..||...||:.||.|||.|..:.:|||.|.|||||||||||||:||:
Human  1436 SLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRK 1500

  Fly  1273 NRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPY 1337
            .:|||:|||||.||.:||.|||:|||::|.|||||||||||:||:|..:|:|:|.|.:.|:|:|.
Human  1501 TKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1565

  Fly  1338 ELMTKSDSKVFHNLVNQSG 1356
            :|:.:..  :|:::...:|
Human  1566 DLLQQRG--LFYSMAKDAG 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	447/1384 (32%)
ABCC1	XP_047290087.1	MRP_assoc_pro	70..1583	CDD:188098	447/1384 (32%)