DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and abcc2

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1409	Identity:	470/1409 - (33%)
Similarity:	755/1409 - (53%)	Gaps:	186/1409 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EKEKVLPENPRARSNFISSLCF-WYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE- 143
            |.:||...||.|::.|:|.:.| |:...:: ||:::.|...|::   :..|:|.. :.:|.::|
Zfish   199 EAKKVAETNPEAKATFLSRITFNWFNSMVW-KGFKRPLVQEDMW---DLNKNDST-HFICQTFED 258

  Fly   144 ---RELK----NDGRSPSLVRALLRVFG------------------------------------- 164
               :|||    |..:..|..|..:...|
Zfish   259 VMAKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSD 323

  Fly   165 ----WQL-----GFPGL----AIFVVELGLRTLQPIFLVKLISYFSGEPDA-ANAGFYYAVAQIV 215
                |.:     .|.|:    |:|.:...|.:.....|:||:..|:...|: |..|:.|||..::
Zfish   324 YPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVL 388

  Fly   216 ISALTVMILTPTTFGIHHVCF----KMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPR 276
            ::.:..::|..    ....||    |:|.|:.:.:::|||.::..:..::|:|.:|||:|.|..|
Zfish   389 VAFVQSVVLQQ----YFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQR 449

  Fly   277 LDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERT 341
            .:.....:|.||..|||:.:....::.|:|.|.:.|:|.|:|.:||..:|.|::...|::..:..
Zfish   450 FNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFK 514

  Fly   342 DNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRG-----FDFARRIV-LS 400
            |:|:::||::::.|::||.||||..||..|...||||:..:|:..|:..     |..|..:| |:
Zfish   515 DSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLA 579

  Fly   401 RVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSE 465
            ..|:|:|    |....:...|.||...:.:|:|...::: :|..|....|...|.:|:|:|:..:
Zfish   580 TFAVFVS----VSPDNILDAEKAFTSISLFNILRFPLAM-LPQLISIMVQTSVSKKRLEKFLSGD 639

  Fly   466 ELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVV 530
            :|.::..:...|                 :.:|:|:.:....|:.:: :..|..::|:||||.:|
Zfish   640 DLDTTTVTHDSS-----------------ITAAVSMTNGTYAWERDT-EPVLKRVSLDIKPGRLV 686

  Fly   531 AVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEE 595
            ||:|..||||:||:.|:||||.:..|.:.:|||::|..|::|:.:.|::.|||||..:|.:||:.
Zfish   687 AVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQS 751

  Fly   596 VVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPLSAVDASVAR 660
            |:|.|||..|.||||.||.|.:||:|..||||||.|:||||:||..|.:|||||||||||:.|.:
Zfish   752 VIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGK 816

  Fly   661 HLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESL--LKTGLITGLGSL 721
            |||::.:  .|.||..|.:|:||...|||:||:||:|.:|.:..:|.||||  .|......|.:.
Zfish   817 HLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRASKGAFSEFLETY 881

  Fly   722 SKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGS-------------------------- 760
            .|.:..|..:::.....:|..: |:..:.|..|....||
Zfish   882 GKDESNKDNDKKAAAAQTPVYE-EIETLPEGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNG 945

  Fly   761 ------------------SSGKEHVERQ--ESGGISLALYRKYFQA-GGGLVAFLVMLSSSVLAQ 804
                              ..|:..:|::  |:|.:..::|.:|..| |...|.|..:.  ..:..
Zfish   946 SVKVRKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVF--YFIQN 1008

  Fly   805 VAVTGGDYFLTYWVKKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLF------- 862
            |||.|.:.:|:.|.        ...:|.......:..:.|.|.:... :.|:..||:|
Zfish  1009 VAVIGQNLWLSDWT--------DDSIEYFNQTYPNHIRDTRIGVFGA-LGLAQGFLVFFGTILLA 1064

  Fly   863 NIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAG 927
            :.:..||..||.::...:.:..|.||.....|.|:|||.||:..|||::|:.....:...|.:.|
Zfish  1065 DGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLG 1129

  Fly   928 IIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRAL 992
            .:.||....|:.....:.::|::|.::..|:.|||.|:|:::::|||:|||...:::||:.|||.
Zfish  1130 TLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAY 1194

  Fly   993 DAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI--CVIYISIITLSFFAFPPGNGADVGL 1055
            ..|....|..:...|.:..:.:.:|.:::.....:..:  .|::.:.: .:..:....|...|||
Zfish  1195 GHQDRFLKRNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAAL-FAVISRDSLNSGLVGL 1258

  Fly  1056 VITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAP--DDKKPPKTWPEQGEII 1118
            .|:.|:.:...:.|.||.|:|||..:.|||||.||..|:.    |||  ...:||..||..|.|.
Zfish  1259 SISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQN----EAPWVTSVRPPDDWPSAGNIR 1319

  Fly  1119 FKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRD 1182
            |::..:||.|  :.|.||..::..||..||:|||||||||||||.|.|||: ...||.:|||..|
Zfish  1320 FEDYKVRYRP--ELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDID 1382

  Fly  1183 TRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASK 1247
            ...:||||||.:::||||:|||||||:|.|||||..:||.::|..||...|||.|..||.||..:
Zfish  1383 IATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHE 1447

  Fly  1248 ISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHR 1312
            :||||.|.|:|||||:|||||:||::|||::|||||.||.:||.|||:|||.:|..|||||||||
Zfish  1448 VSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHR 1512

  Fly  1313 LHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSG 1356
            |:||:||.:|||:|:|::|||.||.||::|...  |.::...:|
Zfish  1513 LNTILDSSRVMVLDSGKIVEFDSPNELLSKPGH--FSSMAEDAG 1554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	464/1386 (33%)
		ABC_membrane	171..437	CDD:294371	82/280 (29%)
		ABCC_MRP_domain1	499..699	CDD:213217	99/201 (49%)
		ABC_membrane	799..1045	CDD:294371	60/254 (24%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	131/221 (59%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	470/1409 (33%)
		ABC_membrane	346..612	CDD:294371	80/273 (29%)
		ABCC_MRP_domain1	656..856	CDD:213217	99/200 (50%)
		ABC_membrane	1001..1270	CDD:279056	66/280 (24%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	131/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660