DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(2)03659 and abcc4

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:NP_001007039.2 Gene:abcc4 / 368620 ZFINID:ZDB-GENE-030616-511 Length:1331 Species:Danio rerio


Alignment Length:1340 Identity:547/1340 - (40%)
Similarity:840/1340 - (62%) Gaps:95/1340 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 EKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELK 147
            :|....||.|.:|..|.:.|.:..|:|..|.::.|:..|::..|.|.:|..||..|.:.|::|.:
Zfish     9 KKDAKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYWDQEKE 73

  Fly   148 ---NDGRSPSLVRALLRVFGWQLGFPGLAIF-VVELGLRTLQPIFLVKLISYFSG----EPDAAN 204
               .:.::|.|.:|::|.: |: .:..|.:| ::|..::.:||:||.|||.||..    :..|.:
Zfish    74 KAAKELKTPKLTKAIIRCY-WK-SYAVLGVFTLIEESIKVIQPVFLGKLIKYFENYRHDDMAALS 136

  Fly   205 AGFYYAVAQIVISALTVMILTPTTFGIHHVCF--------KMRVAMGSMIFRKALRLTKGALGDT 261
            ..:.||.. :.:|.|.:.:|       ||:.|        |:|:||..||:||||.|:..|:|.|
Zfish   137 EAYGYATG-VCLSTLGLALL-------HHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQT 193

  Fly   262 TSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYL 326
            |:|.:|||:|||:.:.|.....:|:|||||||...:..|::||||.|.:.|:..::..||:|...
Zfish   194 TTGQIVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMF 258

  Fly   327 GTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGF 391
            |...|..:.|.|..||:|||.:||::|.|:::||||||:||..:|...|.||::.|....|:||.
Zfish   259 GKLFSKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYLRGL 323

  Fly   392 DFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIR 456
            :.|.....:::.:|::...||::|...:....|:..:.|:.:...::::.|:||.:.::...|||
Zfish   324 NMASFFTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISIR 388

  Fly   457 RVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSPDYTLSGIN 521
            |:::|:..:||             |..:.|.:..|..  :.::.::||...||......||..:.
Zfish   389 RIKKFLLLDEL-------------VKNHLPLSQEEKK--EPSVEMQDLICYWDKTLDAPTLQNVC 438

  Fly   522 LEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTVRQNILFGQ 586
            ..:|||.::||||..|:|||||:..:||||.|..|.::|.|.|:|.||:.|:|.||:|.|||||:
Zfish   439 FTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPGTIRSNILFGK 503

  Fly   587 PMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKASIYLLDDPL 651
            .:..||||.|::.|||:||.:|||..|.|::|:||||||||||||::|||:||:.|.||||||||
Zfish   504 ELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPL 568

  Fly   652 SAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYESLLKTGL-I 715
            |||||.|:||||:|||.|.|:....:|||||.|:|...:||::|..|.:.|.|.|..|.::|| .
Zfish   569 SAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSYSELQQSGLDF 633

  Fly   716 TGL-------------GSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHV 767
            |.|             |...::.:::|..|..:..:|    :.|..:|::|:|.    .:...|.
Zfish   634 TSLLKKDEEEESGSEKGEAPRSPRSRTVSQNSVRSHS----SSVLSVKDDSDQL----PAEPVHT 690

  Fly   768 ---ERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKE-------- 821
               |.:..|.|.:.:|.|||:||..:|..:::|..::|||......|::|:||..::        
Zfish   691 MAEELRSEGNIGIRMYWKYFRAGANVVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLDHNTN 755

  Fly   822 -----STAAGHGEMEDMESKSMDVYKYTLIII----LSVIMNLSSSFLLFNIAKKASIRLHNTIF 877
                 :|:||:      .::.:|:..|..|..    .:::.......::||....::..|||.:|
Zfish   756 NTNTNNTSAGN------TTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVSSAEMLHNRMF 814

  Fly   878 NRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVP 942
            |.:.|..:.||.||..|.|||||:||:..:|.:||...||.:|:.|.:.|:|.|.::|.|.:|:|
Zfish   815 NSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWILIP 879

  Fly   943 TLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQD 1007
            .|.|.:.|..||..:|:||||:||:|:..||||:|||::||.||.||||..|:...::.||::||
Zfish   880 VLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAHQD 944

  Fly  1008 AHSSAFFMYISTSQAFGYCMNCICVIYISIITLSFFAFPPG-NGADVGLVITQAMGLIDMVQWGV 1071
            .||.|:|::::||:.|...::.:|.::::|........... |..||||.::.|:.|:.|.||||
Zfish   945 LHSEAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALSYAVTLMGMFQWGV 1009

  Fly  1072 RQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVL 1136
            ||:||:||.||:|||||||..:|.|...|.  .|:|...||.:|.|.|..:|..|:.:...  ||
Zfish  1010 RQSAEVENMMTSVERVVEYTELESEAPWET--QKRPSPDWPNRGLITFDRVNFSYSSDGPV--VL 1070

  Fly  1137 KSLSFVIQPREKVGIVGRTGAGKSSLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQE 1201
            |::|.:.:|||||||||||||||||||:||||||..:|.:|:|...|.::||||||:::|||||:
Zfish  1071 KNISAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGLHDLRQKMSIIPQD 1135

  Fly  1202 PVLFSGTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLA 1266
            ||||:||||.|||||:::||..||..||||:||..|.:||..|.::::|.|:|||||||||||||
Zfish  1136 PVLFTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVCLA 1200

  Fly  1267 RAILRENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVV 1331
            |||||:||:|::|||||||||:||.|||.|||.||::||||||||||:||||||:::|:||||:.
Zfish  1201 RAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGRIH 1265

  Fly  1332 EFGSPYELMTKSDSKVFHNLVNQSGRASYEGLLKIAQETF 1371
            |:.:|:.|: ::.|.:|:.:|.|:|:|....||:.|::.:
Zfish  1266 EYDAPHVLL-QNQSGIFYKMVQQTGKAEATSLLQTAKQAY 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 537/1304 (41%)
ABC_membrane 171..437 CDD:294371 98/278 (35%)
ABCC_MRP_domain1 499..699 CDD:213217 108/199 (54%)
ABC_membrane 799..1045 CDD:294371 89/262 (34%)
ABCC_MRP_domain2 1115..1336 CDD:213211 140/220 (64%)
abcc4NP_001007039.2 SunT 11..1289 CDD:331423 541/1321 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586025
Domainoid 1 1.000 219 1.000 Domainoid score I2575
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74563
Inparanoid 1 1.050 1131 1.000 Inparanoid score I210
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm26173
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1413.810

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