Protein Alignment l(2)03659 and ABCC6

DIOPT Version :10

• Sequence 1: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Sequence 2: NP_001162.5
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1503
• Species: Homo sapiens
• Alignment Length: 1385
• Identity: 432/1385 - (31%)
• Similarity: 684/1385 - (49%)
• Gaps: 192/1385 - (13%)

  Fly    87 PENPRARSN--------FISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE 143
            ||:|: :||        |.|...||:...:..:|||:.|...||:....|..|:.|.:||...|.
Human   194 PEDPQ-QSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 257

  Fly   144 RE-----------------------------LKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVEL 179
            |.                             |:.:|   |..|.||:.. ||:......:..:.|
Human   258 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEG---SQWRPLLKAI-WQVFHSTFLLGTLSL 318

  Fly   180 GLRTLQPIFLVKLISY---FSGEP-DAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRV 240
            .:..:....:.||:|.   |.|:| ..|..|:..||...:.:.|..:......:.:..:..::|.
Human   319 IISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRS 383

  Fly   241 AMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYL-MYQE 304
            |:..:::||.|.|:.|:...:..|.||||:|.|:.||..:...::.||: ||..:|:.:: ::|.
Human   384 AITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVWIVVCFVYLWQL 447

  Fly   305 IGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQ 369
            :|.||:..:...|..:|:..::..:.:..|.:...:.|:|.|:.:.|:...:.:|.:.||..|..
Human   448 LGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLD 512

  Fly   370 MVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFL-SLVGY----VILGKVFTPEIAFMITAY 429
            .|...|.:|:..:|..    |..|:..:|..:|:.|| :||.:    ::.......|.||:....
Human   513 RVLGIRGQELGALRTS----GLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 573

  Fly   430 YNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADL 494
            .|:|..|.: ::|.:|....|...|..|:..|:..||:.             ||...|:::.:..
Human   574 LNILNKAQA-FLPFSIHSLVQARVSFDRLVTFLCLEEVD-------------PGVVDSSSSGSAA 624

  Fly   495 LKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQ 559
            .|..|:|......|...||. .|..|||.:..|.::||:|..|:|||||:.|:||||....|.:.
Human   625 GKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 688

  Fly   560 VNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATL 624
            :.|:::|..||:|:.:.:|.:|:.|||.:|....|.|::.|||:.|.|..|...:|.:||:|..|
Human   689 IEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNL 753

  Fly   625 SGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLP 687
            |||||.|:||||:|||||::|||||||:|:||.|.:|:|:|.:  .|.|:|:|.:||||....||
Human   754 SGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILP 818

  Fly   688 HVDQIVILANGQIKALGDYESLLK--------------------------------TGLITG--- 717
            ..|.|::||||.|..:|.|:.||:                                .|...|
Human   819 QADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRP 883

  Fly   718 -------LGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGI 775
                   :.|:.:.|:..:|.|..:.|:.||.               .|..:||:.:   :.|.:
Human   884 ELRRERSIKSVPEKDRTTSEAQTEVPLDDPDR---------------AGWPAGKDSI---QYGRV 930

  Fly   776 SLALYRKYFQAGGG---LVAFLVMLSSSVLAQVAVTGGDYFLTYWVK------KESTAAGHGEME 831
            ...::..|.:|.|.   |.|..:.|..    |||.....|:|:.|..      :::.||..|.:
Human   931 KATVHLAYLRAVGTPLCLYALFLFLCQ----QVASFCRGYWLSLWADDPAVGGQQTQAALRGGI- 990

  Fly   832 DMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSI 896
                       :.|:..|..|...:|...:.....:||..|...:...|.|:.:.||.....|.:
Human   991 -----------FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHL 1044

  Fly   897 LNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTS 961
            ||||:|:...||..:|..|..::..|..|..:.:|:|...||..|..|.|.:::...::||:.:|
Human  1045 LNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109

  Fly   962 RDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQ---------RVLEKEFDSY----QDAHSSAF 1013
            ..|:|:|:.:.|.|.||:|.:..|.|.:||...|         ||.|.:..|:    .|...:|.
Human  1110 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAAN 1174

  Fly  1014 FMYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELE 1078
            ...:.....|.   ...|.: :|...||        ...||..::.|:.:...:||.||...:||
Human  1175 VELLGNGLVFA---AATCAV-LSKAHLS--------AGLVGFSVSAALQVTQTLQWVVRNWTDLE 1227

  Fly  1079 NTMTAVERVVEYESIEPEGMLEAPD-DKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFV 1142
            |::.:|||:.:|.....|.....|. ..:||  ||:.|:|.|::..|||.|....  .::.:||.
Human  1228 NSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPL--AVQGVSFK 1288

  Fly  1143 IQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFS 1206
            |...||||||||||||||||.:.|.|| ...:|.:.||......:|||.||.:||||||:|:||.
Human  1289 IHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1353

  Fly  1207 GTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILR 1271
            |::|.|||...|:|||.:|..||.|:||.:|:.||..|..|.::.|.:.||||:||:|||||:||
Human  1354 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLR 1418

  Fly  1272 ENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSP 1336
            :.:||::|||||.|||.|:..:||.:.|.|..||||.|||||.:::|..:|:|||.|:|.|.|||
Human  1419 KTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSP 1483

  Fly  1337 YELMTKSDSKVFHNLVNQSG 1356
            .:|:.:..  :|:.|..:||
Human  1484 AQLLAQKG--LFYRLAQESG 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	432/1385 (31%)
ABCC6	NP_001162.5	MRP_assoc_pro	14..1502	CDD:188098	432/1385 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..919		10/79 (13%)