DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)03659 and ABCC6

DIOPT Version :9

Sequence 1:NP_001260823.1 Gene:l(2)03659 / 47905 FlyBaseID:FBgn0010549 Length:1374 Species:Drosophila melanogaster
Sequence 2:XP_024306029.1 Gene:ABCC6 / 368 HGNCID:57 Length:1515 Species:Homo sapiens


Alignment Length:1385 Identity:432/1385 - (31%)
Similarity:684/1385 - (49%) Gaps:192/1385 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 PENPRARSN--------FISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE 143
            ||:|: :||        |.|...||:...:..:|||:.|...||:....|..|:.|.:||...|.
Human   206 PEDPQ-QSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 269

  Fly   144 RE-----------------------------LKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVEL 179
            |.                             |:.:|   |..|.||:.. ||:......:..:.|
Human   270 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEG---SQWRPLLKAI-WQVFHSTFLLGTLSL 330

  Fly   180 GLRTLQPIFLVKLISY---FSGEP-DAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRV 240
            .:..:....:.||:|.   |.|:| ..|..|:..||...:.:.|..:......:.:..:..::|.
Human   331 IISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRS 395

  Fly   241 AMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYL-MYQE 304
            |:..:::||.|.|:.|:...:..|.||||:|.|:.||..:...::.||: ||..:|:.:: ::|.
Human   396 AITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVWIVVCFVYLWQL 459

  Fly   305 IGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQ 369
            :|.||:..:...|..:|:..::..:.:..|.:...:.|:|.|:.:.|:...:.:|.:.||..|..
Human   460 LGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLD 524

  Fly   370 MVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFL-SLVGY----VILGKVFTPEIAFMITAY 429
            .|...|.:|:..:|..    |..|:..:|..:|:.|| :||.:    ::.......|.||:....
Human   525 RVLGIRGQELGALRTS----GLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTV 585

  Fly   430 YNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADL 494
            .|:|..|.: ::|.:|....|...|..|:..|:..||:.             ||...|:::.:..
Human   586 LNILNKAQA-FLPFSIHSLVQARVSFDRLVTFLCLEEVD-------------PGVVDSSSSGSAA 636

  Fly   495 LKSAISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQ 559
            .|..|:|......|...||. .|..|||.:..|.::||:|..|:|||||:.|:||||....|.:.
Human   637 GKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 700

  Fly   560 VNGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATL 624
            :.|:::|..||:|:.:.:|.:|:.|||.:|....|.|::.|||:.|.|..|...:|.:||:|..|
Human   701 IEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNL 765

  Fly   625 SGGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLP 687
            |||||.|:||||:|||||::|||||||:|:||.|.:|:|:|.:  .|.|:|:|.:||||....||
Human   766 SGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILP 830

  Fly   688 HVDQIVILANGQIKALGDYESLLK--------------------------------TGLITG--- 717
            ..|.|::||||.|..:|.|:.||:                                .|...|   
Human   831 QADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRP 895

  Fly   718 -------LGSLSKTDKAKTEEQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSGKEHVERQESGGI 775
                   :.|:.:.|:..:|.|..:.|:.||.               .|..:||:.:   :.|.:
Human   896 ELRRERSIKSVPEKDRTTSEAQTEVPLDDPDR---------------AGWPAGKDSI---QYGRV 942

  Fly   776 SLALYRKYFQAGGG---LVAFLVMLSSSVLAQVAVTGGDYFLTYWVK------KESTAAGHGEME 831
            ...::..|.:|.|.   |.|..:.|..    |||.....|:|:.|..      :::.||..|.: 
Human   943 KATVHLAYLRAVGTPLCLYALFLFLCQ----QVASFCRGYWLSLWADDPAVGGQQTQAALRGGI- 1002

  Fly   832 DMESKSMDVYKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSI 896
                       :.|:..|..|...:|...:.....:||..|...:...|.|:.:.||.....|.:
Human  1003 -----------FGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHL 1056

  Fly   897 LNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTS 961
            ||||:|:...||..:|..|..::..|..|..:.:|:|...||..|..|.|.:::...::||:.:|
Human  1057 LNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1121

  Fly   962 RDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQ---------RVLEKEFDSY----QDAHSSAF 1013
            ..|:|:|:.:.|.|.||:|.:..|.|.:||...|         ||.|.:..|:    .|...:|.
Human  1122 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAAN 1186

  Fly  1014 FMYISTSQAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELE 1078
            ...:.....|.   ...|.: :|...||        ...||..::.|:.:...:||.||...:||
Human  1187 VELLGNGLVFA---AATCAV-LSKAHLS--------AGLVGFSVSAALQVTQTLQWVVRNWTDLE 1239

  Fly  1079 NTMTAVERVVEYESIEPEGMLEAPD-DKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFV 1142
            |::.:|||:.:|.....|.....|. ..:||  ||:.|:|.|::..|||.|....  .::.:||.
Human  1240 NSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPL--AVQGVSFK 1300

  Fly  1143 IQPREKVGIVGRTGAGKSSLINALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFS 1206
            |...||||||||||||||||.:.|.|| ...:|.:.||......:|||.||.:||||||:|:||.
Human  1301 IHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1365

  Fly  1207 GTMRYNLDPFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILR 1271
            |::|.|||...|:|||.:|..||.|:||.:|:.||..|..|.::.|.:.||||:||:|||||:||
Human  1366 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLR 1430

  Fly  1272 ENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSP 1336
            :.:||::|||||.|||.|:..:||.:.|.|..||||.|||||.:::|..:|:|||.|:|.|.|||
Human  1431 KTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSP 1495

  Fly  1337 YELMTKSDSKVFHNLVNQSG 1356
            .:|:.:..  :|:.|..:||
Human  1496 AQLLAQKG--LFYRLAQESG 1513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)03659NP_001260823.1 CFTR_protein 89..1343 CDD:273530 426/1368 (31%)
ABC_membrane 171..437 CDD:294371 65/275 (24%)
ABCC_MRP_domain1 499..699 CDD:213217 93/201 (46%)
ABC_membrane 799..1045 CDD:294371 66/264 (25%)
ABCC_MRP_domain2 1115..1336 CDD:213211 113/221 (51%)
ABCC6XP_024306029.1 SunT 14..1514 CDD:331423 432/1385 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151607
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1734
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.600

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