DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and CG31792

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster

Alignment Length:	1329	Identity:	767/1329 - (57%)
Similarity:	992/1329 - (74%)	Gaps:	49/1329 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 QNEKEKVLPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWE 143
            |:.|.:.||||||.|||..|:|.||||||.|.||.:.||.:.||||.|:|.:::.|||:||:||.
  Fly     2 QSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWA 66

  Fly   144 RELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLISYFSGEPDAANAGFY 208
            .||:.:.::.||:|.|.||||....|.||.:|.:|: :.|:||:||:||||.|| .|...:.|..
  Fly    67 NELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEV-ILTVQPMFLMKLISSFS-NPSPTSNGVA 129

  Fly   209 YAVAQIVI--SALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLIS 271
            ||.|..||  |||.|:::.|.:|.:.|:..|:||.:.|||:||.|||||..||:.::||::||||
  Fly   130 YAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLIS 194

  Fly   272 NDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLK 336
            ||:.|:|:.....||||:.|||.|::||||||||||:||||:.|:|||:|:|||||.:.|.::||
  Fly   195 NDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLK 259

  Fly   337 AAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSR 401
            .|.|:|.|:|::.|||:.|||:||||||.|||:||.|||.||:|:||...|.:...::....|:.
  Fly   260 TAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTP 324

  Fly   402 VAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEE 466
            |:|||||||:|::|:..|.|:||:|||||||:...|:.|....:.|||:.|.||:||::.:.|.|
  Fly   325 VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE 389

  Fly   467 LGSSDK---SEGPSKD---------------TVPGNPPSNNNEADLLKSAISIRDLKAKWDPNSP 513
            :.:.|:   |.|..:|               ..|..||.|:.:      .:||.:|||||..|||
  Fly   390 VVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSED------CVSISELKAKWTTNSP 448

  Fly   514 DYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSGTV 578
            ||||||:||::..|::||::|.||||||||||||||||:..||:::|.||:||.|||.|||||||
  Fly   449 DYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTV 513

  Fly   579 RQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRKAS 643
            |||||||||||.:||:.||:||||||||:||||:|.||:|:|||:|||||||||||||||||.||
  Fly   514 RQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDAS 578

  Fly   644 IYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANGQIKALGDYES 708
            ||||||||||||:||||.||::|:|||||...|:|||||.|||...|||||:..|::||:|.|||
  Fly   579 IYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYES 643

  Fly   709 LLKTGLITGL-------GSLSKTDKAKTE---EQEPLNLNSPDNKNEVTPIKENSEQTVGGSSSG 763
            |.|:||..|:       .:.:..|:::|.   :|...::.|..:..|..|.....||
  Fly   644 LHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQ-------- 700

  Fly   764 KEHVERQESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHG 828
            |.:::||:.|...|.:|..||:||||.::|.|:::..|.:|...:.|||||:.||.:......|.
  Fly   701 KINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHN 765

  Fly   829 EMEDMESKSMDV---YKYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSI 890
            ...|.:....::   |.|.||.:||:::.:..|||.||:|.:|||:|||::|..::||.|:||:.
  Fly   766 YTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNK 830

  Fly   891 NKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRN 955
            |..|||||||:|||.||||:||.:::.|:|..|...|.|||||.||||.|:|.|...::.|:||:
  Fly   831 NPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRS 895

  Fly   956 LYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTS 1020
            .|||||.|:||:||..|||||||.|||||||:||||..|..:||.|||.|||.||||.:|:||||
  Fly   896 FYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTS 960

  Fly  1021 QAFGYCMNCICVIYISIITLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVE 1085
            :||.|.|:..||::|::||||||.|||.:.|||||.|||||||...|||.|||:|||||||.:||
  Fly   961 RAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVE 1025

  Fly  1086 RVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVG 1150
            |::|||.|||||.|||..||||.::|||||:|.|.||:|||.|..|:|:|||||||||:|:||||
  Fly  1026 RMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVG 1090

  Fly  1151 IVGRTGAGKSSLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDP 1215
            |||||||||||||||||||||.||||.||.:||..|||||||.:||||||||||||||:|:||||
  Fly  1091 IVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDP 1155

  Fly  1216 FDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1280
            ||||||::||..||||:||:||:.:..||.:||:|||:||||||||||||||||||:||||||||
  Fly  1156 FDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDE 1220

  Fly  1281 ATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDS 1345
            ||||||||||.|||||||:|||:|||||:|||||||:|||:|:|||||||||||:||||:|..|:
  Fly  1221 ATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDT 1285

  Fly  1346 KVFHNLVNQSGRASYEGLLKIAQETFESS 1374
            ..|.:||.|:|:|:|:.||||:|..||.|
  Fly  1286 NAFQDLVKQTGQATYDTLLKISQREFEKS 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	746/1286 (58%)
		ABC_membrane	171..437	CDD:294371	142/267 (53%)
		ABCC_MRP_domain1	499..699	CDD:213217	146/199 (73%)
		ABC_membrane	799..1045	CDD:294371	130/248 (52%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	176/220 (80%)
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	745/1284 (58%)
		ABC_membrane	94..360	CDD:294371	142/267 (53%)
		ABCC_MRP_domain1	434..634	CDD:213217	146/199 (73%)
		ABC_membrane	736..980	CDD:294371	125/243 (51%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	176/220 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440869
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810