DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and MRP

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1376	Identity:	461/1376 - (33%)
Similarity:	734/1376 - (53%)	Gaps:	160/1376 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 ENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLY--RPLEEQKSDILGNRLCASWERELK--- 147
            |.|...::|:|.:.:.:...:..||||..|:..||:  || ::..|::: ......|.:.::
  Fly   223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRP-QDSCSEVM-PIFAHHWNQNVRKNY 285

  Fly   148 -------------------------NDGRSPSLVRALLRVFGWQLGFPGLAIF--VVELGLRTL- 184
                                     .:||...:...:..::   ..|.|:.:|  :::|...||
  Fly   286 KNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIY---KSFGGVFLFGALMKLFTDTLT 347

  Fly   185 --QPIFLVKLISYF---SGEPDAANAGFYYAVAQIVISALTVMILTPTTFGIHHVCFKMRVAMGS 244
              ||..|..:||:.   ..||:.  .|..|||...|::|....||......:..|..::|.|:.:
  Fly   348 FAQPQVLSLIISFVEAQDAEPEW--KGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALIN 410

  Fly   245 MIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISA 309
            .|:|||||::.....::|.|.:|||::.|..|.......::.:|..|||:.:..|.::|::|.|.
  Fly   411 AIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSV 475

  Fly   310 VFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHA 374
            :.|:..|::.:|:...:.:|....|::..:..|.|::::||::|.|:|||:||||..||:.|...
  Fly   476 LAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDI 540

  Fly   375 REKEMNTIRQGQYIR-GFDFARRIVLSRVAIFLSLV---GYVILGKV--FTPEIAFMITAYYNVL 433
            |:||:.|:|...|:. |..|    :.|.....:|||   .||:..:.  .:.|...:..|.::::
  Fly   541 RDKEIATLRSTAYLNAGTSF----LWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLM 601

  Fly   434 LAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSA 498
            ...::| :|...:..|:...|:.|:.:|:.||||..:......||.    :|
  Fly   602 KLPLTI-LPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKP----HP------------- 648

  Fly   499 ISIRDLKAKWDPNSPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGS 563
            :||.:.:..|   ..:.||..||:|:|.||:||::|..||||||::||.|||::..:|.:...|.
  Fly   649 MSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGK 710

  Fly   564 LSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQ 628
            |:|..|::|:.:.|||.||||||..|.:||.:|:..|||..|.|:|...|.|.:||:|..|||||
  Fly   711 LAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQ 775

  Fly   629 KARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCV--RGHLRGSTVVLVTHQEQFLPHVDQ 691
            |.||||||:||..|.:||||||||||||.|.:|:|::.:  :|.|...:.|||||...|||.||.
  Fly   776 KQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDS 840

  Fly   692 IVILANGQIKALGDYESLLKT----------GLITG-----------------------LGSLSK 723
            |.::..|:|...|.::.|:|.          .|..|                       ||::.|
  Fly   841 IYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEK 905

  Fly   724 TDK-AKTEE-QEPLNLNSPDN--------KNEVTPIKENSEQTVGGSSSGKE---------HVER 769
            ..| |:||. .:.:::.|.|:        :....  :::|..:|..::|.|:         ..|:
  Fly   906 AIKLARTESLSDSISVTSADSLMGGGGSLRRRTK--RQDSHDSVASAASLKKKQEVEGKLIETEK 968

  Fly   770 QESGGISLALYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWVKKESTAAGHGEMEDME 834
            .::||:..|:|:.|.::.|..::...::.:.|. |....|.:.:||.|...::.|...| :.||
  Fly   969 SQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVF-QAFQIGSNLWLTQWANDQNVANDTG-LRDM- 1030

  Fly   835 SKSMDVY------KYTLIIILSVIMNLSSSFLLFNIAKKASIRLHNTIFNRVTRADM-HFFSINK 892
              .:.||      :..|.....||:.|..    |..||    .:||.:...:.|..: .||.|..
  Fly  1031 --YLGVYGAFGFGQGVLAYFAVVIVYLGG----FQAAK----TIHNELLAVIIRGSVCRFFDITP 1085

  Fly   893 HGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIANVNPLLLVPTLMLSVIFYHLRNLY 957
            .|.:||.|:.||..|||.||..:...|.....:...|:||:...|:.|...:.::.::|..:..|
  Fly  1086 IGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFY 1150

  Fly   958 LKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQA 1022
            :.|||.|.|:|:::|||:|||.:.::.|.:||||.:......:|.|:..|.:....:..:..::.
  Fly  1151 VATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRW 1215

  Fly  1023 FGYCMNCICVIYISIITLSFFAFPPG--NGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVE 1085
            ....:.  .|..:.|:..|.||...|  |...|||.::.|:.:...:.|.||.::::|..:.:||
  Fly  1216 LAIRLE--MVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVE 1278

  Fly  1086 RVVEYESIEPEGMLEAPDDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVG 1150
            |:.||...:.|...|...||..||.||::|.:.|:...:||...  .:.||:.:||.||..||||
  Fly  1279 RIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREG--LDLVLRGVSFNIQGGEKVG 1341

  Fly  1151 IVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLD 1214
            ||||||||||||..|||| :....|.:.||..|...||||.||.:::||||:||||||::|.|||
  Fly  1342 IVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLD 1406

  Fly  1215 PFDEYSDEKLWGCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMD 1279
            ||:..:|:::|..||...||..|..|..||..:|:|||.|.|||||||||||||:||:.::||:|
  Fly  1407 PFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLD 1471

  Fly  1280 EATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSD 1344
            ||||.||.:||.|||.|||::|::||||||||||:||:|||||:|:|.|:::||.||.||:....
  Fly  1472 EATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPK 1536

  Fly  1345 SKVFHNLVNQS 1355
            | .|:::...:
  Fly  1537 S-AFYSMAKDA 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	458/1361 (34%)
		ABC_membrane	171..437	CDD:294371	81/279 (29%)
		ABCC_MRP_domain1	499..699	CDD:213217	98/201 (49%)
		ABC_membrane	799..1045	CDD:294371	68/252 (27%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	126/221 (57%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	461/1376 (34%)
		ABC_membrane	338..601	CDD:279056	79/268 (29%)
		ABCC_MRP_domain1	649..848	CDD:213217	98/201 (49%)
		ABC_membrane	988..1260	CDD:279056	75/286 (26%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440908
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.800