DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)03659 and Sur

DIOPT Version :9

Sequence 1:	NP_001260823.1	Gene:	l(2)03659 / 47905	FlyBaseID:	FBgn0010549	Length:	1374	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	2033	Identity:	434/2033 - (21%)
Similarity:	716/2033 - (35%)	Gaps:	812/2033 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SNFISSLCFWYTIPIFRKGYRKTLDSTDL-YRPLEEQKSDILGNRLCASWERELKNDGRSPSLVR 157
            :.|.|..|||:..|:...||::.|:..|| ...||:.......:.|....|::.|::. ||||..
  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNS-SPSLWY 289

  Fly   158 ALLRVFGWQL----GFPGLA--IFVVELGLRTLQPIFLVKLISYF------SGEPDAANAGFYYA 210
            ..:: ..||:    |...||  :|.:      :.|:.:.|::.|.      :.||.|.:.|  ..
  Fly   290 CYIK-NSWQMFALGGILKLAGDLFAL------IGPLAIQKIVEYIEQLYAQASEPPAKSPG--NE 345

  Fly   211 VAQIVISALTVM------------------------------------ILTPTTFG--------- 230
            ||.:::|...::                                    :|...|.|
  Fly   346 VANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHI 410

  Fly   231 IHHVCFKMRVAMGSMIFRKALRL----------TKGALGDTTS---------------------- 263
            ::....:::.::..:|:||:|.|          :.|.:..|:|
  Fly   411 LNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPS 475

  Fly   264 --------GHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFM 320
                    |.:.|.::.|...:......:||.|..|.::.|:.||:|..:|||||.|.:..::.|
  Fly   476 EPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIM 540

  Fly   321 -PIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQ 384
             |:|.::|...|......|..||.|::.:::.:..|:|:|:.||::.|.:.:..||.||:..:.:
  Fly   541 TPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNK 605

  Fly   385 ------------------------GQYI-----RGFDFARRIVLSRVAIFLSLVGYVILGKVFTP 420
                                    |.|:     :.||.....:.|.:|:|..|.         .|
  Fly   606 DATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLT---------VP 661

  Fly   421 EIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEE--------------LGSSD 471
            .:.|.||.  .:::||.               .|.||:|:|::|.|              |..||
  Fly   662 LLIFPITV--PIIIAAR---------------VSTRRLERFLKSSEIQKQFEGIRNMARILSKSD 709

  Fly   472 --------------------------------KSEGP----------------SKDTVPG----- 483
                                            ||:.|                ::|..|.
  Fly   710 ASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQEL 774

  Fly   484 ---------------------NPP----------------------SNNNEADLLKS----AISI 501
                                 .||                      |...::.|||.    |:||
  Fly   775 GHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSI 839

  Fly   502 RDLKAKWDPNS--PDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQL--QVNG 562
            .|....|.|.|  |...|....:.:..|.:..|:|..||||:||:.|:|.|:...:|.:  ....
  Fly   840 NDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTC 904

  Fly   563 SLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGG 627
            ::||.||:.||.:.|:|:|||||:....:||:.|::.|||:.|.:|:|..|.:|:||||..:|||
  Fly   905 TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGG 969

  Fly   628 QKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGS--TVVLVTHQEQFLPHVD 690
            |:.||::||::|..|::.::||||:::|..|..|:|..|:|..|:.|  |.:|||.|...:...:
  Fly   970 QRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAE 1034

  Fly   691 QIVILANGQIKALGDY--------------------------------------------ESLLK 711
            .::.:.:|:::|.|.|                                            :::.|
  Fly  1035 YLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSK 1099

  Fly   712 TGL-------------------------------------------------------------- 714
            .||
  Fly  1100 LGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRS 1164

  Fly   715 -----------------------------------------------ITGLGSLSKT-------- 724
                                                           ::||.:|:.|
  Fly  1165 SIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISG 1229

  Fly   725 ----------------------------------------------------------------D 725
                                                                            |
  Fly  1230 DVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPD 1294

  Fly   726 KAKTEE--------QEPLN------------------LNSPDN-------KNEVTPIKENS---- 753
            ..|:||        :.||:                  .|.|.|       .|.:..|.|.|
  Fly  1295 VKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVV 1359

  Fly   754 -------------------------------EQTVG-----GSSSGKE--------------HVE 768
                                           |.|:.     .|:|.||              |.|
  Fly  1360 HFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNE 1424

  Fly   769 RQ-------ESGGISLAL------------------YRKYFQAGGGLVAFLVMLSSSVLAQVAVT 808
            |.       |||..|:.|                  |..|.:| .||....:...::::.|....
  Fly  1425 RHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRA-AGLPIITIFFITALIWQCLRV 1488

  Fly   809 GGDYFLTYW--VKKESTAAGHGEMEDMESKSMDVY---KYTLIIILSVIMNLSSSFLLFNIAKKA 868
            ..|.:|..|  |.....:.||..:...|......|   .|..|..:.:||.|.|:.........|
  Fly  1489 YTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNA 1553

  Fly   869 SIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLAGIIIVIA 933
            ...||:.:...:....:|||.:...|.|:|||:.||:.:|:.:......::|..|.....|::..
  Fly  1554 RRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINV 1618

  Fly   934 NVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRALDAQRVL 998
            .:.|.:||.||.:...:|.::..|..::|:|:|:|....|||.|||:.::.|:|||||.:.|...
  Fly  1619 TITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRF 1683

  Fly   999 EKEFDSYQDAHSSAFFMYISTSQAFGYCMNCI--CVIYISIITLSFFA-----------FPPGNG 1050
            .:......:|::.|:.:..::.:..|..::.:  |:::::.:|....|           ..|...
  Fly  1684 TEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSAS 1748

  Fly  1051 AD----------------------VGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY--- 1090
            |.                      |||.|...:.:...:.|.|:..|::|....:|||:..|
  Fly  1749 ASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQG 1813

  Fly  1091 ------------------------------------------ESIEP------------------ 1095
                                                      :.:.|
  Fly  1814 QDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRI 1878

  Fly  1096 ----------------EGMLEAPDDK----------------KPPKT------------------ 1110
                            |...||..||                .||.|
  Fly  1879 GGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDK 1943

  Fly  1111 --------------------------------WPEQGEIIFKELNLRYTPNAKAENVLKSLSFVI 1143
                                            ||::|:|.|..::|||  ..:.:||:.:|:..|
  Fly  1944 QLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRY--EGQKQNVISNLTLKI 2006

  Fly  1144 QPREKVGIVGRTGAGKSSLINALFR-LSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSG 1207
            ...:::||.||||:|||||..:||. |..|.|.:.||..|.:::...:||.::|||||:..||:.
  Fly  2007 PAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNA 2071

  Fly  1208 TMRYNLDPFDEYSDEKLWGCLEEVKLKEVVS-DLPDGLASKISEGGTNFSVGQRQLVCLARAILR 1271
            |:|.||||...:.|.:||.|||..:|||.|: .||.||.:.|.:||.|.|.|.|||:||||||||
  Fly  2072 TIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILR 2136

  Fly  1272 ENRILVMDEATANVDPQTDGLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSP 1336
            .:..||:||||:.:|..|:..:.......||..|::||||||.||:|.|:::|:|.||:||.|:|
  Fly  2137 GSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNP 2201

  Fly  1337 YELMTKSDSKVFHNLVNQ 1354
            .||. :.:..||..|:.:
  Fly  2202 RELQ-QLEGSVFRGLLEK 2218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)03659	NP_001260823.1	CFTR_protein	89..1343	CDD:273530	431/2020 (21%)
		ABC_membrane	171..437	CDD:294371	73/388 (19%)
		ABCC_MRP_domain1	499..699	CDD:213217	76/205 (37%)
		ABC_membrane	799..1045	CDD:294371	62/263 (24%)
		ABCC_MRP_domain2	1115..1336	CDD:213211	103/222 (46%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160